Demand for Wine in Australia: Systems Versus Single Equation Approach

The objective of the study is to estimate demand for wine in Australia, based on both the systems approach and the single equation approach. Both approaches consider demand for three categories of alcoholic drinks (beer, wine and spirits) in a seemingly unrelated regression framework to take account of cross-equation correlations. Time series data on retail price indexes and apparent per capita consumption of alcoholic beverages for Australia for the period 1975/76 to 1998/99 are used for econometric estimation. The results show that over the short run, beer and wine are necessities; however, over the long run, wine becomes a luxury good. Beer and wine are complements. Demand for all three beverages is price inelastic. The study also found that the behaviour of wine consumers reflect past consumption patterns, indicating that wine is more addictive than either beer or spirits. A structural change in consumer preferences away from cheaper cask wines to more expensive bottled table wines has a significant impact on the volume of wine consumption. Finally, wine consumption has increased over time. The study re-confirms the importance of developing a model that considers the impacts of both economic and non-economic variables on wine consumption.wine demand, demand analysis, almst ideal demand system, Demand and Price Analysis,

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis

Background & Aims: Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeutically target these cells. Here, we aimed to identify the origins and contribution of colorectal CAFs associated with poor prognosis. Methods: To elucidate CAF origins, we used a colitis-associated CRC mouse model in 5 different fate-mapping mouse lines with 5-bromodeoxyuridine dosing. RNA sequencing of fluorescence-activated cell sorting–purified CRC CAFs was performed to identify a potential therapeutic target in CAFs. To examine the prognostic significance of the stromal target, CRC patient RNA sequencing data and tissue microarray were used. CRC organoids were injected into the colons of knockout mice to assess the mechanism by which the stromal gene contributes to colorectal tumorigenesis. Results: Our lineage-tracing studies revealed that in CRC, many ACTA2+ CAFs emerge through proliferation from intestinal pericryptal leptin receptor (Lepr)+ cells. These Lepr-lineage CAFs, in turn, express melanoma cell adhesion molecule (MCAM), a CRC stroma-specific marker that we identified with the use of RNA sequencing. High MCAM expression induced by transforming growth factor β was inversely associated with patient survival in human CRC. In mice, stromal Mcam knockout attenuated orthotopically injected colorectal tumoroid growth and improved survival through decreased tumor-associated macrophage recruitment. Mechanistically, fibroblast MCAM interacted with interleukin-1 receptor 1 to augment nuclear factor κB–IL34/CCL8 signaling that promotes macrophage chemotaxis. Conclusions: In colorectal carcinogenesis, pericryptal Lepr-lineage cells proliferate to generate MCAM+ CAFs that shape the tumor-promoting immune microenvironment. Preventing the expansion/differentiation of Lepr-lineage CAFs or inhibiting MCAM activity could be effective therapeutic approaches for CRC

Demand for Wine in Australia: Systems Versus Single Equation Approach

The objective of the study is to estimate demand for wine in Australia, based on both the systems approach and the single equation approach. Both approaches consider demand for three categories of alcoholic drinks (beer, wine and spirits) in a seemingly unrelated regression framework to take account of cross-equation correlations. Time series data on retail price indexes and apparent per capita consumption of alcoholic beverages for Australia for the period 1975/76 to 1998/99 are used for econometric estimation. The results show that over the short run, beer and wine are necessities; however, over the long run, wine becomes a luxury good. Beer and wine are complements. Demand for all three beverages is price inelastic. The study also found that the behaviour of wine consumers reflect past consumption patterns, indicating that wine is more addictive than either beer or spirits. A structural change in consumer preferences away from cheaper cask wines to more expensive bottled table wines has a significant impact on the volume of wine consumption. Finally, wine consumption has increased over time. The study re-confirms the importance of developing a model that considers the impacts of both economic and non-economic variables on wine consumption

The Demand for Wine in Australia Using a Systems Approach: Industry Implications

The objective of this study is to explain the factors determining the demand for wine in Australia, based on a systems approach where wine demand is modelled as part of the broader demand for alcoholic drinks (beer, wine and spirits). Time series data on retail price indexes and apparent per capita consumption of alcoholic beverages for Australia for the period 1975/76 to 1998/99 are used for econometric estimation of an Almost Ideal Demand System. The results show that the demand for beer and wine is price inelastic and that both beer and wine are luxury goods. The study also found that current beer and wine consumption strongly follows past consumption patterns. Drink driving campaigns have not had a significant effect on alcoholic consumption, but there seems to have been a structural change in consumer preferences that has a significant impact on the volume of wine consumption. Finally, there seems to have been an overall upward trend in wine consumption and a downward trend for beer consumption. The study re-confirms the importance of developing a model that considers the impacts of both economic and non-economic variables on wine consumption. Implications for wine industry marketing strategies are suggested

The Demand for Wine in Australia Using a Systems Approach: Industry Implications

The objective of this study is to explain the factors determining the demand for wine in Australia, based on a systems approach where wine demand is modelled as part of the broader demand for alcoholic drinks (beer, wine and spirits). Time series data on retail price indexes and apparent per capita consumption of alcoholic beverages for Australia for the period 1975/76 to 1998/99 are used for econometric estimation of an Almost Ideal Demand System. The results show that the demand for beer and wine is price inelastic and that both beer and wine are luxury goods. The study also found that current beer and wine consumption strongly follows past consumption patterns. Drink driving campaigns have not had a significant effect on alcoholic consumption, but there seems to have been a structural change in consumer preferences that has had a significant impact on the volume of wine consumption. Finally, there seems to have been an overall upward trend in wine consumption and a downward trend for beer consumption. The study re-confirms the importance of developing a model that considers the impacts of both economic and non-economic variables on wine consumption. Implications for wine industry marketing strategies are suggested