Elasticity Theory Connection Rules for Epitaxial Interfaces

Elasticity theory provides an accurate description of the long-wavelength vibrational dynamics of homogeneous crystalline solids, and with supplemental boundary conditions on the displacement field can also be applied to abrupt heterojunctions and interfaces. The conventional interface boundary conditions, or connection rules, require that the displacement field and its associated stress field be continuous through the interface. We argue, however, that these boundary conditions are generally incorrect for epitaxial interfaces, and we give the general procedure for deriving the correct conditions, which depend essentially on the detailed microscopic structure of the interface. As a simple application of our theory we analyze in detail a one-dimensional model of an inhomogeneous crystal, a chain of harmonic oscillators with an abrupt change in mass and spring stiffness parameters. Our results have implications for phonon dynamics in nanostructures such as superlattices and nanoparticles, as well as for the thermal boundary resistance at epitaxial interfaces.Comment: 7 pages, Revte

Enhanced Deep Blue Aerosol Retrieval Algorithm: The Second Generation

The aerosol products retrieved using the MODIS collection 5.1 Deep Blue algorithm have provided useful information about aerosol properties over bright-reflecting land surfaces, such as desert, semi-arid, and urban regions. However, many components of the C5.1 retrieval algorithm needed to be improved; for example, the use of a static surface database to estimate surface reflectances. This is particularly important over regions of mixed vegetated and non- vegetated surfaces, which may undergo strong seasonal changes in land cover. In order to address this issue, we develop a hybrid approach, which takes advantage of the combination of pre-calculated surface reflectance database and normalized difference vegetation index in determining the surface reflectance for aerosol retrievals. As a result, the spatial coverage of aerosol data generated by the enhanced Deep Blue algorithm has been extended from the arid and semi-arid regions to the entire land areas

Evaluating 'Prefer not to say' Around Sensitive Disclosures

As people's offline and online lives become increasingly entwined, the sensitivity of personal information disclosed online is increasing. Disclosures often occur through structured disclosure fields (e.g., drop-down lists). Prior research suggests these fields may limit privacy, with non-disclosing users being presumed to be hiding undesirable information. We investigated this around HIV status disclosure in online dating apps used by men who have sex with men. Our online study asked participants (N=183) to rate profiles where HIV status was either disclosed or undisclosed. We tested three designs for displaying undisclosed fields. Visibility of undisclosed fields had a significant effect on the way profiles were rated, and other profile information (e.g., ethnicity) could affect inferences that develop around undisclosed information. Our research highlights complexities around designing for non-disclosure and questions the voluntary nature of these fields. Further work is outlined to ensure disclosure control is appropriately implemented around online sensitive information disclosures

Social richness, socio-technical tension and the virtual commissioning of NHS research

<p>Abstract</p> <p>Background</p> <p>This paper draws on a recent study that evaluated the process of commissioning NHS funded research using virtual committees. Building on an earlier paper that reported our evaluation, here we focus on the effects of asynchronous computer mediated communication (CMC) when used to support group work.</p> <p>Methods</p> <p>To do this the discussion focuses on how CMC affected three key group factors, building relationships, group cohesion and group commitment. The notion of socio-technical tension is elaborated and the paper explores how social richness can act to counter the socially impoverishing and time extending effects of asynchronous CMC.</p> <p>Results</p> <p>We argue that social richness in this context results from the presence of five principal influences. These are: a dynamic range of participant aspirations and personal agendas; participant commitment to and identification with the work and ideals of the group; a rich diversity of social, professional and work-related backgrounds; a website designed to enhance participation and interaction and the mediating effects of an effective chairperson.</p> <p>Conclusion</p> <p>If virtual work groups are to be used by the NHS in the future, then there is a need for more research into the role of social context and its relationship to the effectiveness of newly formed virtual groups. Equally as important are studies that examine the effects of socio-technical interaction on groups undertaking tasks in the real world of work.</p

Orchestrating Shots for the National Ignition Facililty (NIF)

The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, is a stadium-sized facility containing a 192-beam, 1.8 Megajoule, 500-Terawatt, ultra-violet laser system together with a 10-meter diameter target chamber with room for nearly 100 experimental diagnostics. When completed, NIF will be the world's largest and most energetic laser experimental system, providing an international center to study inertial confinement fusion and physics of matter at extreme densities and pressures. The NIF is operated by the Integrated Computer Control System (ICCS), which is a layered architecture of over 700 lower-level front-end processors attached to nearly 60,000 control points and coordinated by higher-level supervisory subsystems in the main control room. A shot automation framework has been developed and deployed during the past year to orchestrate and automate shots performed at the NIF using the ICCS. The Shot Automation framework is designed to automate 4-8 hour shot sequences, that includes deriving shot goals from an experiment definition, set up of the laser and diagnostics, automatic alignment of laser beams, and a countdown to charge and fire the lasers. These sequences consist of set of preparatory verification shots, leading to amplified system shots followed by post-shot analysis and archiving. The framework provides for a flexible, model-based work-flow execution, driven by scripted automation called macro steps. The shot director software is the orchestrating component of a very flexible automation layer which allows us to define, coordinate and reuse simpler automation sequences. This software provides a restricted set of shot life cycle state transitions to 26 collaboration supervisors that automate 8-laser beams (bundle) and a common set of shared resources. Each collaboration supervisor commands approximately 10 subsystem shot supervisors that perform automated control and status verification. Collaboration supervisors translate shot life cycle state commands from shot director into sequences of ''macro steps'' to be distributed to each of its shot supervisors, maintains order of macro steps for each subsystem, and supports collaboration between macro steps. They also manage failure, restarts, and rejoining into the shot cycle (if necessary) and manage auto/manual macro step execution and collaborations between other collaboration supervisors. Each macro step has database-driven verification phases and a scripted perform phase. This provides for a highly flexible framework for performing a variety of NIF shot types. Database tables define the order of work and dependencies (workflow) of macro steps to be performed for a shot. A graphical model editor facilitates the definition and viewing of an execution model. A change manager tool enables ''de-participation'' of individual devices, of entire laser segments (beams, quads, or bundles of beams) or individual diagnostics. This software has been deployed to the NIF facility and is currently being used to support NIF main laser commissioning shots and build-out of the NIF laser. This will be used to automate future target and experimental shot campaigns

Shot Automation for the National Ignition Facility

A shot automation framework has been developed and deployed during the past year to automate shots performed on the National Ignition Facility (NIF) using the Integrated Computer Control System This framework automates a 4-8 hour shot sequence, that includes inputting shot goals from a physics model, set up of the laser and diagnostics, automatic alignment of laser beams and verification of status. This sequence consists of set of preparatory verification shots, leading to amplified system shots using a 4-minute countdown, triggering during the last 2 seconds using a high-precision timing system, followed by post-shot analysis and archiving. The framework provides for a flexible, model-based execution driven of scriptable automation called macro steps. The framework is driven by high-level shot director software that provides a restricted set of shot life cycle state transitions to 25 collaboration supervisors that automate 8-laser beams (bundles) and a common set of shared resources. Each collaboration supervisor commands approximately 10 subsystem shot supervisors that perform automated control and status verification. Collaboration supervisors translate shot life cycle state commands from the shot director into sequences of ''macro steps'' to be distributed to each of its shot supervisors. Each Shot supervisor maintains order of macro steps for each subsystem and supports collaboration between macro steps. They also manage failure, restarts and rejoining into the shot cycle (if necessary) and manage auto/manual macro step execution and collaborations between other collaboration supervisors. Shot supervisors execute macro step shot functions commanded by collaboration supervisors. Each macro step has database-driven verification phases and a scripted perform phase. This provides for a highly flexible methodology for performing a variety of NIF shot types. Database tables define the order of work and dependencies (workflow) of macro steps to be performed for a shot. A graphical model editor facilitates the definition and viewing of an execution model. A change manager tool enables ''de-participation'' of individual devices, of entire laser segments (beams, quads, or bundles of beams) or individual diagnostics. This software has been deployed to the NIF facility and is currently being used to support NIF main laser commissioning shots and build-out of the NIF laser. This will be used to automate future target and experimental shot campaigns

Status of the National Ignition Facility Integrated Computer Control System (ICCS) on the Path to Ignition

The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory is a stadium-sized facility under construction that will contain a 192-beam, 1.8-Megajoule, 500-Terawatt, ultraviolet laser system together with a 10-meter diameter target chamber with room for multiple experimental diagnostics. NIF is the world's largest and most energetic laser experimental system, providing a scientific center to study inertial confinement fusion (ICF) and matter at extreme energy densities and pressures. NIF's laser beams are designed to compress fusion targets to conditions required for thermonuclear burn, liberating more energy than required to initiate the fusion reactions. NIF is comprised of 24 independent bundles of 8 beams each using laser hardware that is modularized into more than 6,000 line replaceable units such as optical assemblies, laser amplifiers, and multifunction sensor packages containing 60,000 control and diagnostic points. NIF is operated by the large-scale Integrated Computer Control System (ICCS) in an architecture partitioned by bundle and distributed among over 800 front-end processors and 50 supervisory servers. NIF's automated control subsystems are built from a common object-oriented software framework based on CORBA distribution that deploys the software across the computer network and achieves interoperation between different languages and target architectures. A shot automation framework has been deployed during the past year to orchestrate and automate shots performed at the NIF using the ICCS. In December 2006, a full cluster of 48 beams of NIF was fired simultaneously, demonstrating that the independent bundle control system will scale to full scale of 192 beams. At present, 72 beams have been commissioned and have demonstrated 1.4-Megajoule capability of infrared light. During the next two years, the control system will be expanded to include automation of target area systems including final optics, target positioners and diagnostics, in preparation for project completion in 2009. Additional capabilities to support fusion ignition shots in a National Ignition Campaign (NIC) beginning in 2010 will include a cryogenic target system, target diagnostics, and integrated experimental shot data analysis with tools for data visualization and archiving. This talk discusses the current status of the control system implementation and discusses the plan to complete the control system on the path to ignition

A Novel Function of DELTA-NOTCH Signalling Mediates the Transition from Proliferation to Neurogenesis in Neural Progenitor Cells

A complete account of the whole developmental process of neurogenesis involves understanding a number of complex underlying molecular processes. Among them, those that govern the crucial transition from proliferative (self-replicating) to neurogenic neural progenitor (NP) cells remain largely unknown. Due to its sequential rostro-caudal gradients of proliferation and neurogenesis, the prospective spinal cord of the chick embryo is a good experimental system to study this issue. We report that the NOTCH ligand DELTA-1 is expressed in scattered cycling NP cells in the prospective chick spinal cord preceding the onset of neurogenesis. These Delta-1-expressing progenitors are placed in between the proliferating caudal neural plate (stem zone) and the rostral neurogenic zone (NZ) where neurons are born. Thus, these Delta-1-expressing progenitors define a proliferation to neurogenesis transition zone (PNTZ). Gain and loss of function experiments carried by electroporation demonstrate that the expression of Delta-1 in individual progenitors of the PNTZ is necessary and sufficient to induce neuronal generation. The activation of NOTCH signalling by DELTA-1 in the adjacent progenitors inhibits neurogenesis and is required to maintain proliferation. However, rather than inducing cell cycle exit and neuronal differentiation by a typical lateral inhibition mechanism as in the NZ, DELTA-1/NOTCH signalling functions in a distinct manner in the PNTZ. Thus, the inhibition of NOTCH signalling arrests proliferation but it is not sufficient to elicit neuronal differentiation. Moreover, after the expression of Delta-1 PNTZ NP continue cycling and induce the expression of Tis21, a gene that is upregulated in neurogenic progenitors, before generating neurons. Together, these experiments unravel a novel function of DELTA–NOTCH signalling that regulates the transition from proliferation to neurogenesis in NP cells. We hypothesize that this novel function is evolutionary conserved

Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling

The Notch signaling pathway controls numerous cell fate decisions during development and adulthood through diverse mechanisms. Thus, whereas it functions as an oscillator during somitogenesis, it can mediate an all-or-none cell fate switch to influence pattern formation in various tissues during development. Furthermore, while in some contexts continuous Notch signaling is required, in others a transient Notch signal is sufficient to influence cell fate decisions. However, the signaling mechanisms that underlie these diverse behaviors in different cellular contexts have not been understood. Notch1 along with two downstream transcription factors hes1 and RBP-Jk forms an intricate network of positive and negative feedback loops, and we have implemented a systems biology approach to computationally study this gene regulation network. Our results indicate that the system exhibits bistability and is capable of switching states at a critical level of Notch signaling initiated by its ligand Delta in a particular range of parameter values. In this mode, transient activation of Delta is also capable of inducing prolonged high expression of Hes1, mimicking the “ON” state depending on the intensity and duration of the signal. Furthermore, this system is highly sensitive to certain model parameters and can transition from functioning as a bistable switch to an oscillator by tuning a single parameter value. This parameter, the transcriptional repression constant of hes1, can thus qualitatively govern the behavior of the signaling network. In addition, we find that the system is able to dampen and reduce the effects of biological noise that arise from stochastic effects in gene expression for systems that respond quickly to Notch signaling