Methodology for the innovation of business games

El presente artículo explica las acciones llevadas a cabo por una compañía dedicada al diseño e implementación de experiencias educativas utilizando simuladores de negocios, como parte del proceso de actualización de su portafolio. Este proceso consta de una metodología con ocho etapas que han sido implementadas para incorporar la sostenibilidad como aspecto relevante en la narrativa de un simulador y en consecuencia, en la toma de decisiones y la evaluación de competencias a partir de ellas. El objetivo principal de la metodología es la alineación de los simuladores a tendencias de negocios para desarrollar competencias relevantes y demandadas por las organizaciones. Los resultados obtenidos a partir de la implementación de la metodología han permitido una planificación del despliegue de la misma, utilizando los retos identificados para la innovación del portafolio de la compañía, de cara a las instituciones educativas que incluyen simuladores de negocios como parte de su propuesta de valor.The present paper explains the phases of an update process performed by a company which focuses on designing and implementing educational experiences using business games. The methodology for this process consists of eight phases that have been implemented to incorporate sustainability as a relevant aspect in the narrative of one of the simulators and, consequently, in decision-making and evaluation of competencies based on them. The main goal of this process is to align the portfolio to the latest business trends in order to develop relevant skills demanded by organizations. The results obtained from this implementation have been useful for planning its development using other relevant challenges, contemplating other products of the portfolio

Deep Learning versus Classical Regression for Brain Tumor Patient Survival Prediction

Deep learning for regression tasks on medical imaging data has shown promising results. However, compared to other approaches, their power is strongly linked to the dataset size. In this study, we evaluate 3D-convolutional neural networks (CNNs) and classical regression methods with hand-crafted features for survival time regression of patients with high grade brain tumors. The tested CNNs for regression showed promising but unstable results. The best performing deep learning approach reached an accuracy of 51.5% on held-out samples of the training set. All tested deep learning experiments were outperformed by a Support Vector Classifier (SVC) using 30 radiomic features. The investigated features included intensity, shape, location and deep features. The submitted method to the BraTS 2018 survival prediction challenge is an ensemble of SVCs, which reached a cross-validated accuracy of 72.2% on the BraTS 2018 training set, 57.1% on the validation set, and 42.9% on the testing set. The results suggest that more training data is necessary for a stable performance of a CNN model for direct regression from magnetic resonance images, and that non-imaging clinical patient information is crucial along with imaging information.Comment: Contribution to The International Multimodal Brain Tumor Segmentation (BraTS) Challenge 2018, survival prediction tas

Mediterranean model of Pharmacy and the freedom of establishment in the European Union

El marco jurídico europeo relativo a oficinas de farmacia se encuentra en la Directivas de 1985 de armonización de las legislaciones nacionales que establecen las condiciones para el ejercicio profesional del farmacéutico. La reglamentación de la Unión Europea no recoge un criterio comunitario para la planificación farmacéutica. Las Directivas de armonización de las legislaciones nacionales de los Estados miembros reconocen la competencia estatal en materia de establecimiento farmacéutico. Estas premisas dan lugar a la existencia de diferencias entre las legislaciones nacionales respecto a los principios de limitación para el establecimiento. La Comisión de la UE se planteó la compatibilidad de estas legislaciones con el principio comunitario de libertad de establecimiento proclamado por el Tratado. El objetivo de esta comunicación es hacer un seguimiento en el procedimiento planteado contra España y analizar la adecuación de las legislaciones cuestionadas al derecho comunitario a la luz de la jurisprudencia del Tribunal de Justicia de la Unión Europea.The European legal framework relating to pharmacies located on the directives of 1985 on the harmonization of national laws which set conditions for professional pharmacists. The EU regulation does not include a community approach for pharmaceutical planning. Directives to harmonize national laws of Member States recognize the state competition in the field of pharmaceutical establishment. These assumptions lead to the existence of differences between national laws on the principles of limitation for the facility. The EU Commission considers the compatibility of these laws with the EU principle of freedom of establishment proclaimed by the Treaty. The purpose of this communication is to monitor the proceedings brought against Spain and to assess the adequacy of the laws challenged with Community law in light of the Court of Justice of the European Union

Observation of the suppressed Λ0b→DpK− decay with D→K+π− and measurement of its CP asymmetry

A study of Λ0b baryon decays to the DpK− final state is presented based on a proton-proton collision data sample corresponding to an integrated luminosity of 9  fb−1 collected with the LHCb detector. Two Λ0b decays are considered, Λ0b→DpK− with D→K−π+ and D→K+π−, where D represents a superposition of D0 and ¯D0 states. The latter process is expected to be suppressed relative to the former, and is observed for the first time. The ratio of branching fractions of the two decays is measured, and the CP asymmetry of the suppressed mode, which is sensitive to the Cabibbo-Kobayashi-Maskawa angle γ, is also reported

Evidence for the strangeness-changing weak decay Ξb−→Λb0π−\Xi_b^-\to\Lambda_b^0\pi^-

Using a $pp$ collision data sample corresponding to an integrated luminosity of 3.0~fb$^{-1}$, collected by the LHCb detector, we present the first search for the strangeness-changing weak decay $\Xi_b^-\to\Lambda_b^0\pi^-$. No $b$ hadron decay of this type has been seen before. A signal for this decay, corresponding to a significance of 3.2 standard deviations, is reported. The relative rate is measured to be ${{f_{\Xi_b^-}}\over{f_{\Lambda_b^0}}}{\cal{B}}(\Xi_b^-\to\Lambda_b^0\pi^-) = (5.7\pm1.8^{+0.8}_{-0.9})\times10^{-4}$, where $f_{\Xi_b^-}$ and $f_{\Lambda_b^0}$ are the $b\to\Xi_b^-$ and $b\to\Lambda_b^0$ fragmentation fractions, and ${\cal{B}}(\Xi_b^-\to\Lambda_b^0\pi^-)$ is the branching fraction. Assuming $f_{\Xi_b^-}/f_{\Lambda_b^0}$ is bounded between 0.1 and 0.3, the branching fraction ${\cal{B}}(\Xi_b^-\to\Lambda_b^0\pi^-)$ would lie in the range from $(0.57\pm0.21)\%$ to $(0.19\pm0.07)\%$

Updated search for B+cBc+ decays to two charm mesons

A data set corresponding to an integrated luminosity of 9 fb−1 of proton-proton collisions collected by the LHCb experiment has been analysed to search for B+c→D(∗)+(s)(---)D(∗)0Bc+→D(s)(∗)+(---)D(∗)0 decays. The decays are fully or partially reconstructed, where one or two missing neutral pions or photons from the decay of an excited charm meson are allowed. Upper limits for the branching fractions, normalised to B+ decays to final states with similar topologies, are obtained for sixteen B+cBc+ decay modes. For the decay B+c→D+sD¯¯¯¯0Bc+→Ds+D¯0, an excess with a significance of 3.4 standard deviations is found

Simultaneous determination of CKM angle γ and charm mixing parameters

A combination of measurements sensitive to the CP violation angle γ of the Cabibbo-Kobayashi-Maskawa unitarity triangle and to the charm mixing parameters that describe oscillations between D0 and D¯¯¯¯D¯0 mesons is performed. Results from the charm and beauty sectors, based on data collected with the LHCb detector at CERN's Large Hadron Collider, are combined for the first time. This method provides an improvement on the precision of the charm mixing parameter y by a factor of two with respect to the current world average. The charm mixing parameters are determined to be x=(0.400+0.052−0.053)%x=(0.400−0.053+0.052)% and y = (0.630+0.033−0.030)%(0.630−0.030+0.033)%. The angle γ is found to be γ = (65.4+3.8−4.2)∘(65.4−4.2+3.8)∘ and is the most precise determination from a single experiment

Model-Independent Observation of Exotic Contributions to B degrees -> J/psi K+pi(-) Decays

An angular analysis of B degrees -> J/psi K+pi(-) decays is performed, using proton-proton collision data corresponding to an integrated luminosity of 3 fb(-1) collected with the LHCb detector. The m(K+pi(-) ) spectrum is divided into fine bins. In each m(K+pi(-)) bin, the hypothesis that the three-dimensional angular distribution can be described by structures induced only by K* resonances is examined, making minimal assumptions about the K+pi(-) system. The data reject the K*-only hypothesis with a large significance, implying the observation of exotic contributions in a model-independent fashion. Inspection of the m(J/psi pi(-)) vs m(K+pi(-)) plane suggests structures near m(J/psi pi(-)) = 4200 and 4600 MeV