Two-year management after renal transplantation in 2013 in France: Input from the French national health system database

International audienceThe objective of this study was to describe the management of patients undergoing renal transplantation in 2013 and over the following two years on the basis of healthcare consumption data. The National Health Insurance Information System was used to identify 1876 general scheme beneficiaries undergoing a first isolated renal transplantation (median age: 53 years; men 63%). Overall, 1.2% of patients died during the transplantation hospital stay (>65 years 3.3%) and 87% of patients had a functional graft at 2 years. Thirty-three percent of patients were readmitted to hospital for 1 day or longer during the first month, 73% the first year and 55% the second year. At least 10% of patients were hospitalised for antirejection treatment during the first quarter after renal transplantation, 16% the first year and 9% the second year. The first year, 32% of patients were hospitalised for renal disease (12% the second year), 14% were hospitalised for cardiovascular disease (9% the second year), 13% for infectious disease (5% the second year) and 2% for a malignant tumour (2% the second year). Almost 80% of patients consulted their general practitioner each year (almost 50% consulted every quarter). During the second year, 83% of patients were taking antihypertensives, 45% lipid-lowering drugs, 26% antidiabetic drugs, 77% tacrolimus, 18% ciclosporin, 88% mycophenolic acid and 69% corticosteroids. This study highlights the important contribution of healthcare consumption data to a better understanding of the modalities of management of renal transplant recipients in France, allowing improvement of this management in line with guidelines

Middle Pleistocene Human Remains from Tourville-la-Rivière (Normandy, France) and Their Archaeological Context

International audienc

Enhancing the learning of evolutionary anthropology skills by combining student‐active teaching with actual and virtual immersion of Master's students in fieldwork, laboratory practice, and dissemination

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ESR dating results calculated using the standard US [60] and the closed system (CS)-US [61] models.

<p>(*) For this sample, age calculation was performed using the dentine U-series data for the enamel as well. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104111#pone.0104111.s001" target="_blank">File S1</a> for further details.</p><p>ESR dating results calculated using the standard US <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104111#pone.0104111-Grn1" target="_blank">[60]</a> and the closed system (CS)-US <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104111#pone.0104111-Grn2" target="_blank">[61]</a> models.</p

The Tourville left upper limb remains.

<p>Top: humerus; bottom left: ulna; bottom right: radius. For all the bones: A: anterior view; M: medial view; P: posterior view; L: lateral view.</p

CT-based 3D mapping of the topographic distribution of the cortical bone at the proximal part of the humeral diaphysis (A) compared to the equivalent area (B, 6 cm below the deltoid tuberosity) on the humerus of the Krapina # 165 Pre-Neandertal (NESPOS data base, [<b>40</b>]) (B).

<p>Cortical thickness topographic variation was rendered using a chromatic scale increasing from dark blue (thin) to red (thick). The arrows indicate the position of the deltoid tuberosity in both shafts. a: anterior view, b: posterior view, c: medial view, d: lateral view.</p

The Tourville 1 human remains in anterior view placed adjacent to the left arm bones of the Tabun 1 female Neandertal.

<p>The humeri are aligned according to the medial supracondylar crest, the ulnae using the brachialis tuberosity, and the radii using the radial tuberosity. Scale 5 cm.</p