Collision warning dissemination in vehicles strings: An empirical measurement

Inter-Vehicular Communications (IVC) are considered a promising technological approach for enhancing transportation safety and improving highway efficiency. Previous theoretical work has demonstrated the benefits of IVC in vehicles strings. Simulations of partially IVC-equipped vehicles strings showed that only a small equipment ratio is sufficient to drastically reduce the number of head on collisions. However, these results are based on the assumptions that IVC exhibit lossless and instantaneous messages transmission. This paper presents the research design of an empirical measurement of a vehicles string, with the goal of highlighting the constraints introduced by the actual characteristics of communication devices. A warning message diffusion system based on IEEE 802.11 wireless technology was developed for an emergency breaking scenario. Preliminary results are presented as well, showing the latencies introduced by using 802.11a and discussing early findings and experimental limitation

Reconstruction et analyse d'interactions de neutrinos dans les blocs cibles émulsions d'OPERA et discrimination du fond charmé dans le canal -> 3h

CHAMBERY -BU Bourget (730512101) / SudocSTRASBOURG-Bib.Central Recherche (674822133) / SudocSudocFranceF

Les vertus de la discussion

International audienc

Les vertus de la discussion

International audienc

Cushing’s syndrome due to interaction between ritonavir or cobicistat and corticosteroids: a case–control study in the French Pharmacovigilance Database

International audienceOBJECTIVES:To explore the frequent interaction between antiretroviral-boosting agents and corticosteroids causing Cushing's syndrome (CS) in the French Pharmacovigilance Database (FPVD).METHODS:We conducted a retrospective case-control study describing CS recorded in the FPVD between 1996 and 2018. Case was defined as CS occurring in people living with HIV (PLWH) and control was defined as CS in uninfected individuals. Drug-drug interaction (DDI) was defined as an interaction between corticosteroids and CYP3A4 inhibitors. Data concerning the DDI, corticosteroids involved, route of administration and seriousness of the CS were described.RESULTS:Among the 139 instances of CS identified, 34/35 cases (97%) had DDIs (31 with ritonavir and 3 with cobicistat) and 7/104 controls (7%) had DDIs (6 with itraconazole and 1 with verapamil). The main corticosteroid involved was inhaled fluticasone (28/35, 80%) among the cases and oral prednisone (38/104, 37%) among the controls. More CS cases (30/35, 86%) than CS controls (62/104, 60%) were serious (OR = 4.0, 95% CI = 1.4-14.4; P = 0.007).CONCLUSIONS:Antiretroviral-boosting agents were responsible for one out of four iatrogenic CS cases in a French national database. Prescribers should be aware of the risk of potentially serious DDIs between antiretroviral-boosting agents and corticosteroids, including single-tablet regimens containing cobicistat

Immatérialités de la mort

De nouvelles pratiques funéraires, entre réel et virtuel, marquent ce début de xxie siècle. À l’heure des éternités numériques, un nouveau champ d’expression du mourir surgit et le lien avec les défunts se pérennise et se modifie. De quelles façons notre rapport à la mort s’est-il métamorphosé dans le contexte de la mondialisation et de la médiatisation des dernières décennies ? Comment se dématérialise la sociabilité funèbre, comment se transforme le soin fourni aux cadavres ? Quelle gestion mortuaire, d’ordre politique et symbolique, adopter face aux dépouilles indésirables (attentats-suicides) ou en cas de corps souillés (guerre, génocide) ou absents (migrants) ? Dans une perspective pluridisciplinaire et comparatiste, cet Essentiel d’Hermès aborde la mort comme un phénomène de communication vital qui engage notre rapport à l’altérité et à l’identité

Enjeux et débats en didactiques des mathématiques: XVIIIe école d’été de didactique des mathématiques, Brest (Bretagne) – 19-26 août 2015

International audienceLa 18e école d’été de didactique des mathématiques s’est tenue à Brest du 19 au 26 août 2015, les responsables du comité scientifique étaient Yves Matheron et Ghislaine Gueudet. Le travail scientifique associant cours, travaux dirigés, séminaires, posters et temps de débat, était organisé autour de deux thèmes et d’une question vive : un thème mathématique, relatif à l’enseignement de l’analyse (responsables : Maryza Krysinska, Tomás Sierra et Marc Rogalski) ; un thème transversal, portant sur le collectif en didactique (responsables : Luc Trouche et Carl Winsløw) ; une question vive : « doit-on parler de la didactique ou des didactiques ? » (responsables : Serge Quilio et Tomás Sierra). L’école d’été elle-même était précédée d’une demi-journée adressée aux jeunes chercheurs (responsables : Charlotte Derouet et Christian Spitalas).On retrouvera dans cet ouvrage les textes correspondant aux contenus de l’école, organisés en deux volumes. Le volume I sous forme papier pour les cours, conférences, réactions, et pour la table ronde. Le volume II sous forme de Cédérom pour les travaux dirigés associés aux cours, et les communications orales et affichées

The Use of Ferritin to Identify Critically Ill Patients With Secondary Hemophagocytic Lymphohistiocytosis*

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Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice

International audienceThis study addressed the hypothesis that inhibition of the EETs degrading enzyme soluble epoxide hydrolase affords renal protection in the early stage of diabetic nephropathy. The renal effects of the sEH inhibitor t-AUCB (10 mg/l in drinking water) were compared to those of the sulfonylurea glibenclamide (80 mg/l), both administered for 8 weeks in FVB mice subjected to a high-fat diet (HFD, 60% fat) for 16 weeks. Mice on control chow diet (10% fat) and non-treated HFD mice served as controls. Compared with non-treated HFD mice, HFD mice treated with t-AUCB had a decreased EET degradation, as shown by their higher plasma EETs-to-DHETs ratio, and an increased EET production, as shown by the increase in EETs+DHETs levels, which was associated with induction of CYP450 epoxygenase expression. Both agents similarly reduced fasting glycemia but only t-AUCB prevented the increase in the urinary albumine-to-creatinine ratio in HFD mice. Histopathological analysis showed that t-AUCB reduced renal inflammation, which was associated with an increased mRNA expression of the NFκB inhibitor IκB and related decrease in MCP-1, COX2 and VCAM-1 expressions. Finally, there was a marginally significant increase in reactive oxygen species production in HFD mice, together with an enhanced NOX2 expression. Both agents did not modify these parameters but t-AUCB increased the expression of the antioxidant enzyme superoxide dismutase 1. These results demonstrate that, independently from its glucose-lowering effect, sEH inhibition prevents microalbuminuria and rena