An isotopic effect in phi photoproduction at a few GeV

A distinct isotopic effect in phi photoproduction at 2-5 GeV region is identified by examining the production amplitudes due to Pomeron-exchange and meson-exchange mechanisms. This effect is mainly caused by the pi-eta interference constrained by SU(3) symmetry and the isotopic structure of the gamma NN coupling in the direct phi-radiation amplitude. It can be tested experimentally by measuring differences in the polarization observables between the gamma-p and gamma-n reactions.Comment: 11 pages, 6 figure

Leptoquark pair production at the Fermilab Tevatron: Signal and backgrounds

We perform a Monte-Carlo simulation of scalar leptoquark pair production at the Tevatron (energy =1.8 TeV and luminosity =100 pb^{-1}) with ISAJET. We also investigate the dominant sources of Standard Model background: Z*jj, ZZ production and heavy quark top-antitop. We find that the top-antitop background is the most important except near the Z pole where the Z*jj background is peaked. We also evaluate the signal-to-background ratio and find a discovery reach of 130 GeV (170 GeV) for a branching ratio of B(LQ-> eq)=0.5 (B=1).Comment: 8 pages, 6 figures, latex (revtex

Supplementary data for article: Selaković, Ž.; Tran, J. P.; Kota, K. P.; Lazić, M.; Retterer, C.; Besh, R.; Panchal, R. G.; Soloveva, V.; Sean, V. A.; Jay, W. B.; et al. Second Generation of Diazachrysenes: Protection of Ebola Virus Infected Mice and Mechanism of Action. European Journal of Medicinal Chemistry 2019, 162, 32–50. https://doi.org/10.1016/j.ejmech.2018.10.061

Supplementary material for: [https://www.sciencedirect.com/science/article/pii/S0223523418309383?via%3Dihub]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/360]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/2966

Scalar and Vector Leptoquark Pair Production at Hadron Colliders: Signal and Backgrounds

We perform a systematic analysis of scalar and vector leptoquark pair production at the Fermilab Tevatron and at the CERN LHC. We evaluate signal expectations and background levels for the processes pp (p ppar) -> 2 jets + e^{+} + e^{-} and 2 jets + e + missing p_T. The Monte Carlo event generator ISAJET is used to simulate the experimental conditions at the current (Sqrt{s}=1.8 TeV, Luminosity=100 pb^{-1}) and upgraded (Luminosity=100 pb^{-1}) Tevatron as well as the LHC (Sqrt{s}=14 TeV, Luminosity=10 fb^{-1}). Depending on the luminosity, and assuming a branching ratio B(LQ -> eq)=0.5, we find a discovery reach up to 170 (255) GeV for scalar leptoquarks at the current (upgraded) Tevatron. Similarly, we find vector leptoquarks to be detectable at masses below 300 (400) GeV depending on the coupling. At the LHC, the discovery reach is enhanced to 1 TeV for scalar leptoquarks and to 1.5 TeV for vectors.Comment: 15 pages (REVTEX), 12 figures, submitted to Phys. Rev.

ПЕДІАТРИЧНА ОСВІТА УКРАЇНИ У ХХІ СТОРІЧЧІ: СУЧАСНІ ВИКЛИКИ ТА ПРОБЛЕМИ МАЙБУТНЬОГО

The aim of the work – to evaluate the state of development of pediatric education in Ukraine in the beginning of the 21st century, staffing of the branch in the field of pediatrics and to develop a plan of measures to overcome the crisis phenomena in pediatric health care. The main body. The article presents data on the development of pediatric education in the early 21st century after the restoration of the educational-scientific specialty “Pediatrics” in 2017. The development of up-to-date standards for the training of pediatric doctors, based on the acquisition of future master’s degrees in pediatrics, general and professional competencies and necessary practical skills is highlighted. The current problems in the provision of pediatric health care facilities are emphasized. Conclusion. A list of measures at the sectoral and national level has been developed to restore the necessary training рediatricians for childrenʼs health care of the country and to ensure the proper methodological provision of the educational process, which may cause difficulties in providing children with quality medical care in the future.Мета роботи – оцінити стан розвитку педіатричної освіти в Україні на початку ХХІ сторіччя, кадрове забезпечення галузі за спеціальністю «Педіатрія» та розробити план заходів щодо подолання кризових явищ у педіатричній охороні здоровʼя. Основна частина. У статті наведено дані щодо розвитку педіатричної освіти на початку ХХІ сторіччя після відновлення освітньо-наукової спеціальності «Педіатрія» у 2017 р. Висвітлено розробку сучасних стандартів підготовки дитячих лікарів, що базуються на набутті майбутніми магістрами педіатрії загальних та фахових компетенцій і необхідних практичних навичок. Наголошено на теперішніх проблемах у кадровому забезпеченні педіатричних закладів охорони здоровʼя, що може викликати складнощі у забезпеченні дітей якісною медичною допомогою у майбутньому. Висновок. Розроблений перелік заходів на галузевому та загальнодержавному рівні щодо відновлення необхідних для країни обсягів підготовки дитячих лікарів та забезпечення належного методичного забезпечення навчального процесу

GENDER PECULIARITIES OF BRONCHIAL ASTHMA COURSE IN PATIENTS WITH BODY MASS DIFFERENCE

Bronchial asthma is among the most common diseases of the respiratory system. Increased incidence of bronchial asthma can be associated with obesity that is more common nowadays. Fatty tissue plays a special role in the formation of systemic inflammation, which differs depending on gender. The aim of the research was to compare peculiarities of clinical course and spirometry indices in patients with bronchial asthma and body mass difference depending on gender. A complete clinical examination of 104 patients with persistent BA in an inpatient department has been performed. Depending on body mass index, all patients were divided into three subgroups: the first one included 36 patients with normal body mass, the second subgroup 34 overweight patients, and the third subgroup 34 patients with obesity. In each subgroup, most patients suffered from persistent BA of moderate degree, mild course was usually observed in overweight patients. Severe course was more common in patients with obesity and normal body mass. To detect gender peculiarities, we analyzed data of case histories and peculiarities of clinical course. It was revealed that 91.6% of women with obesity had reported onset of the disease in middle age, and 40% of men had suffered since childhood. In the subgroup with normal body mass, 59.1% of men and 57.1% of women suffered less than 10 years. Thus, the disease progressed more rapidly in obese women, while there was not gender difference in disease duration under conditions of normal body mass. Complicated course was much more common in women. However, men more often suffered from type 2 diabetes mellitus. Gender differences in the spirometry indices were analyzed separately in women and men depending on body mass. In obese women, of all spirometry indices, only MEF75 decreased. It proves that more marked obstructive changes are observed at the level of tiny branches of the bronchial tree in obese women. In overweight men, FVC, IVC, FEV1 and PEF were lower than in the subgroup with normal mass. These indices were also significantly lower in the subgroup of patients with obesity. Thus, in men, increase in body mass has more influence on speed and volume of air in spirometry indices. To perform thorough gender analysis, we compared spirometry indices in overweight men and women and obese individuals together and revealed some peculiarities. In men, the majority of spirometry indices are significantly lower than in women, indicating more severe course of the disease. Among them, all indices confirm restrictive changes in the lungs and FEV1 is the main marker of broncho-obstructive syndrome. Besides, more manifested obstructive changes were observed in men both at the level of the main, secondary and tertiary bronchi. Conclusion. Excessive body mass in men has more manifested influence on speed and volume of air in spirometry indices. Such marked changes in respiratory function can be explained by the fact that abdominal obesity is more common in men, which contributes to the decrease in volume and speed indices due to restrictive diaphragmatic excursion and, as a result, deterioration of broncho-obstructive syndrome

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral activities of two classes of compounds which show high potency against EBOV in both in vitro cell culture assays and in vivo mouse models Ebola viral disease. These compounds incorporate the structural features of cationic amphiphilic drugs (CAD), i.e they possess both a hydrophobic domain and a hydrophilic domain consisting of an ionizable amine functional group. These structural features enable easily diffusion into cells but once inside an acidic compartment their amine groups became protonated, ionized and remain trapped inside the acidic compartments such as late endosomes and lysosomes. These compounds, by virtue of their lysomotrophic functions, blocked EBOV entry. However, unlike other drugs containing a CAD moiety including chloroquine and amodiaquine, compounds reported in this study display faster kinetics of accumulation in the lysosomes, robust expansion of late endosome/lysosomes, relatively more potent suppression of lysosome fusion with other vesicular compartments and inhibition of cathepsins activities, all of which play a vital role in anti-EBOV activity. Furthermore, the diazachrysene 2 (ZSML08) that showed most potent activity against EBOV in in vitro cell culture assays also showed significant survival benefit with 100% protection in mouse models of Ebola virus disease, at a low dose of 10 mg/kg/day. Lastly, toxicity studies in vivo using zebrafish models suggest no developmental defects or toxicity associated with these compounds. Overall, these studies describe two new pharmacophores that by virtue of being potent lysosomotrophs, display potent anti-EBOV activities both in vitro and in vivo animal models of EBOV disease. © 2018 Elsevier Masson SASSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/2967]Peer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/2966

Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+