Capacity expansion in liberalized electricity markets with locational pricing and renewable energy investments.

We study the long-term incentives for expanding production capacity in liberalized electricity markets. How does electricity market design affect the prices of energy, capacity and social welfare? And how is this capacity market affected by the geographical features of the electricity market? Should the system operator design the capacity market to provide incentives for investment in renewable technologies? We analyze the conditions under which capacity payments and markets enable higher investment relative to an energy-only market in which generators sell electricity but not capacity. We show that capacity markets benefit consumers and investors by increasing investment and reliability and capping peak prices. We prove that generators benefit from owning a portfolio of peak and baseload plants and show that investment strategies must consider regional capacity auctions. We demonstrate that a capacity payment per technology increases investment in renewable technologies and leads to the early retirement of older, carbon-emitting technologies. Regional capacity investment targets effectively decrease energy prices and significantly increase investment in renewable technologies

Impact of initial stress field heterogeneity in dynamic soil–structure interaction

This article covers the impact of soil initial stress field heterogeneity (ISFH) in wave-passage analysis and in prescribed structural acceleration in the context of dynamic soil–structure interaction (DSSI) analysis. ISFH is directly related to the natural behavior of soil where a significant increase in net effective confinement, as is the case in the foundation soil under a building, tends to increase the soil’s modulus and strain. This creates a heterogeneous stress field in the vicinity of the foundation elements, which results in a modification of the dynamic behavior of the soil–structure system. A simple method for considering the impact of ISFH on the value of the soil’s modulus and strain was developed using the direct DSSI approach. The method was used to analyze numerical artifacts and its impact on the surface acceleration values of a nonlinear two-dimensional (2D) numerical soil deposit under transient loading. This analysis was followed by a sample application for a three-story, three-bay concrete moment-resisting frame structure erected on a deep soil deposit. Floor acceleration and relative displacement were used for comparison. The soil deposit was modeled using the typical geotechnical properties of fine-grained, post-glacial soil samples obtained in Eastern Canada from in situ geotechnical borehole drilling, geophysical surveys, and laboratory testing. Ground motion was based on eastern calibrated seismic signals. The results of the soil deposit analysis show that ISFH had a significant impact on surface acceleration values. The effect was found to be period-dependent and to have a direct impact on prescribed acceleration values at the base of structure. Thus, failure to take the effects of ISFH into consideration can lead to errors in calculating prescribed structural accelerations (i.e. over- or underestimation). -- Keywords : Dynamic soil–structure interaction ; direct modeling ; finite element ; Eastern Canada ; post-glacial deposits

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

A single-cell expression atlas of clear cell renal cell carcinoma

National audienc