Optical counterparts of undetermined type γ\gamma-ray Active Galactic Nuclei with blazar-like Spectral Energy Distributions

During its first four years of scientific observations, the Fermi Large Area Telescope (Fermi-LAT) detected 3033 $\gamma$-ray sources above a 4$\sigma$ significance level. Although most of the extra-Galactic sources are active galactic nuclei (AGN) of the blazar class, other families of AGNs are observed too, while a still high fraction of detections ($\sim 30\%$) remains with uncertain association or classification. According to the currently accepted interpretation, the AGN $\gamma$-ray emission arises from inverse Compton (IC) scattering of low energy photons by relativistic particles confined in a jet that, in the case of blazars, is oriented very close to our line of sight. Taking advantage of data from radio and X-ray wavelengths, which we expect to be produced together with $\gamma$-rays, providing a much better source localization potential, we focused our attention on a sample of $\gamma$-ray Blazar Candidates of Undetermined Type (BCUs), starting a campaign of optical spectroscopic observations. The main aims of our investigation include a census of the AGN families that contribute to $\gamma$-ray emission and a study of their redshift distribution, with the subsequent implications on the intrinsic source power. We furthermore analyze which $\gamma$-ray properties can better constrain the nature of the source, thus helping in the study of objects not yet associated with a reliable low frequency counterpart. In this communication we report on the instruments and techniques used to identify the optical counterparts of $\gamma$-ray sources, we give an overview on the status of our work, and we discuss the implications of a large scale study of $\gamma$-ray emitting AGNs.Comment: 9 pages, 2 figures, proceedings of the 10th Serbian Conference on Spectral Line Shapes in Astrophysics. JOAA, accepte

A spectroscopic analysis of a sample of narrow-line Seyfert 1 galaxies selected from the Sloan Digital Sky Survey

We revisited the spectroscopic characteristics of narrow-line Seyfert 1 galaxies (NLS1s) by analysing a homogeneous sample of 296 NLS1s at redshift between 0.028 and 0.345, extracted from the Sloan Digital Sky Survey (SDSS-DR7) public archive. We confirm that NLS1s are mostly characterized by Balmer lines with Lorentzian profiles, lower black hole masses and higher Eddington ratios than classic broad-line Seyfert 1 (BLS1s), but they also appear to be active galactic nuclei (AGNs) contiguous with BLS1s and sharing with them common properties. Strong Fe II emission does not seem to be a distinctive property of NLS1s, as low values of Fe II/H$\beta$ are equally observed in these AGNs. Our data indicate that Fe II and Ca II kinematics are consistent with the one of H$\beta$. On the contrary, O I $\lambda$8446 seems to be systematically narrower and it is likely emitted by gas of the broad-line region more distant from the ionizing source and showing different physical properties. Finally, almost all NLS1s of our sample show radial motions of the narrow-line region highly-ionised gas. The mechanism responsible for this effect is not yet clear, but there are hints that very fast outflows require high continuum luminosities (> $10^{44}$ erg/s) or high Eddington ratios (log(L$_{\rm bol}$/L$_{\rm Edd}$) > -0.1).Comment: 27 pages, 31 figures, 4 tables, accepted for publication in MNRA

[O III] line properties in two samples of radio-emitting narrow-line Seyfert 1 galaxies

The [O III] $\lambda\lambda$ 4959,5007 lines are a useful proxy to test the kinematic of the narrow-line region (NLR) in active galactic nuclei (AGN). In AGN, and particularly in narrow-line Seyfert 1 galaxies (NLS1s) these lines often show few peculiar features, such as blue wings, often interpreted as outflowing component, and a shift $-$ typically toward lower wavelengths $-$ of the whole spectroscopic feature in some exceptional sources, the so-called blue outliers, which are often associated to strong winds. We investigated the incidence of these peculiarities in two samples of radio-emitting NLS1s, one radio-loud and one radio-quiet. We also studied a few correlations between the observational properties of the [O III] lines and those of the AGN. Our aim was to understand the difference between radio-quiet and radio-loud NLS1s, which may in turn provide useful information on the jet formation mechanism. We find that the NLR gas is much more perturbed in radio-loud than in radio-quiet NLS1s. In particular the NLR dynamics in $\gamma$-ray emitting NLS1s appears to be highly disturbed, and this might be a consequence of interaction with the relativistic jet. The less frequently perturbed NLR in radio-quiet NLS1s suggests instead that these sources likely do not harbor a fully developed relativistic jet. Nonetheless blue-outliers in radio-quiet NLS1s are observed, and we interpret them as a product of strong winds.Comment: 16 pages, 13 figures, 7 tables, accepted for publication on Astronomy & Astrophysic

HIV-1 Tat alters neuronal intrinsic excitability

Objective: In HIV+ individuals, the virus enters the central nervous system and invades innate immune cells, producing important changes that result in neurological deficits. We aimed to determine whether HIV plays a direct role in neuronal excitability. Of the HIV peptides, Tat is secreted and acts in other cells. In order to examine whether the HIV Tat can modify neuronal excitability, we exposed primary murine hippocampal neurons to that peptide, and tested its effects on the intrinsic membrane properties, 4 and 24 h after exposure. Results: The exposure of hippocampal pyramidal neurons to Tat for 4 h did not alter intrinsic membrane properties. However, we found a strong increase in intrinsic excitability, characterized by increase of the slope (Gain) of the input-output function, in cells treated with Tat for 24 h. Nevertheless, Tat treatment for 24 h did not alter the resting membrane potential, input resistance, rheobase and action potential threshold. Thus, neuronal adaptability to Tat exposure for 24 h is not applicable to basic neuronal properties. A restricted but significant effect on coupling the inputs to the outputs may have implications to our knowledge of Tat biophysical firing capability, and its involvement in neuronal hyperexcitability in neuroHIV

Detecting Extrasolar Planets with Integral Field Spectroscopy

Observations of extrasolar planets using Integral Field Spectroscopy (IFS), if coupled with an extreme Adaptive Optics system and analyzed with a Simultaneous Differential Imaging technique (SDI), are a powerful tool to detect and characterize extrasolar planets directly; they enhance the signal of the planet and, at the same time, reduces the impact of stellar light and consequently important noise sources like speckles. In order to verify the efficiency of such a technique, we developed a simulation code able to test the capabilities of this IFS-SDI technique for different kinds of planets and telescopes, modelling the atmospheric and instrumental noise sources. The first results obtained by the simulations show that many significant extrasolar planet detections are indeed possible using the present 8m-class telescopes within a few hours of exposure time. The procedure adopted to simulate IFS observations is presented here in detail, explaining in particular how we obtain estimates of the speckle noise, Adaptive Optics corrections, specific instrumental features, and how we test the efficiency of the SDI technique to increase the signal-to-noise ratio of the planet detection. The most important results achieved by simulations of various objects, from 1 M_J to brown dwarfs of 30 M_J, for observations with an 8 meter telescope, are then presented and discussed.Comment: 60 pages, 37 figures, accepted in PASP, 4 Tables adde

Effects of 6 weeks of traditional resistance training or high intensity interval resistance training on body composition, aerobic power and strength in healthy young subjects: A randomized parallel trial

Consistent practice of physical activity has well known positive effects on general health; however, time for exercise remains one major barrier for many. An acute bout of high intensity interval resistance training (HIIRT) increases acute resting energy expenditure (REE) and decreases respiratory ratio (RR), suggesting its potential role on weight loss and increased fatty acid oxidation. The aim of this study was to test the long-term effect of HIIRT on body composition, lipid profile and muscle strength using a randomized parallel trial. Twenty healthy young adults (22.15 ± 1.95 years) were randomized to perform either a HIIRT (N = 11) protocol, consisting of three sets of 6 repetitions at 6 repetition maximum (RM) and then 20 seconds of rest between repetitions until exhaustion repeated for 3 times with 2’30″ rest between sets or a traditional training (TRT, N = 9) protocol of 3 sets of 15 reps with 75 sec of rest between sets. Body composition, resting energy metabolism, aerobic capacity, muscle strength and blood measurements were taken before and after 8 weeks of training. Both protocols enhanced muscle strength, but only HIIRT improved endurance strength performance (+22.07%, p < 0.05) and lean body mass (+2.82%, p < 0.05). REE and RR were unaltered as lipid profile. HIIRT represents a valid training method to improve muscle strength and mass, but its role on body weight control was not confirmed

Aqueous Humor Biomarkers of M\ufcller Cell Activation in Diabetic Eyes.

PURPOSE: To identify early biomarkers of retinal M\ufcller cell activation in diabetic eyes with or without clinically detectable signs of diabetic retinopathy (DR). METHODS: This study was a cross-sectional comparative case series. The aqueous humor (AH) of 34 eyes was collected in 12 healthy controls, 11 diabetic patients without DR, and 11 diabetic patients with nonproliferative DR. Full ophthalmic examination and spectral-domain optical coherence tomography were performed in all eyes. Glial fibrillary acidic protein (GFAP), aquaporin 1 (AQP1), and aquaporin 4 (AQP4) were quantified in AH samples as biomarkers of M\ufcller cell activity by ELISA. Statistical analysis was performed with ANOVA followed by Tukey-Kramer post hoc test. RESULTS: There was no significant difference in the age among the three groups. Mean concentration of GFAP, AQP1, and AQP4 significantly increased in diabetic eyes versus controls (P < 0.05, for each comparison). Glial fibrillary acidic protein and AQP1 showed an approximate 2-fold increase, whereas AQP4 showed an approximate 25-fold increase in diabetics with DR versus controls. In diabetics without DR, AQP4 showed an approximate 6-fold increase versus controls. CONCLUSIONS: Glial fibrillary acidic protein, AQP1, and AQP4-biomarkers of M\ufcller cell activity-are significantly increased in human eyes with diabetes, confirming that M\ufcller cells are precociously affected by diabetes mellitus

Modelling of ultrasound transmission through a solid-liquid interface comprising a network of gas pockets

International audienceUltrasonic inspection of sodium-cooled fast reactor requires a good acoustic coupling between the transducer and the liquid sodium. Ultrasonic transmission through a solid surface in contact with liquid sodium can be complex due to the presence of microscopic gas pockets entrapped by the surface roughness. Experiments are run using substrates with controlled roughness consisting of a network of holes and a modeling approach is then developed. In this model, a gas pocket stiffness at a partially solid-liquid interface is defined. This stiffness is then used to calculate the transmission coefficient of ultrasound at the entire interface. The gas pocket stiffness has a static, as well as an inertial component, which depends on the ultrasonic frequency and the radiative mass