Distribuzione ed evoluzione delle associazioni a piccoli mammiferi nella penisola italiana durante il Pleistocene superiore

This work focus on evolution of small mammals assemblages in the Italian peninsula during Upper Pleistocene and on the analysis of differences between synchronous faunas of various zones. Data obtained from the study of micromammals of Caverna degli Orsi (San Dorligo della Valle, Dolina, Trieste), Ciota Ciara (Borgosesia, Vercelli) Riparo Mochi (Ventimiglia, Imperia), Grotta Paglicci (Rignano Garganico, Foggia) e Riparo Tagliente (Stallavena di Grezzana, Verona) have been presented in order to provide evidences from important Upper Pleistocene sequences and to throw light on this subject. For each species it has been given a brief description of systematics, ecology, geographic distribution and presumable modifications occurred during the last phases of Pleistocene. Furthermore, reviwing and rearranging before-known Italian sites, it was possible to make general remarks on environmental changes and on chronology of faunal associations under examination. The analysis of small mammals shows that Italian peninsula can be divided into geographic zones presenting several different landscapes and biodiversity grades. Specifically, in northern Adriatic zone, Valpadana and piedmont bend species coming from Eastern Europe, such as Microtus oeconomus and Sicista betulina, are present; southern Adriatic zone is characterized by marked aridity and low biodiversity degree while southern Thyrrenian zone display richer assemblages normally associated with wooden environments. Finally, all the results have been processed in order to suggest a biochronological model as detailed as possible, in which the most important sequences of Italian peninsula have been positioned and linked to the isotopic curve

Il rischio cardiovascolare e la concentrazione plasmatica del colesterolo LDL: il ruolo dei Servizi Sanitari Regionali

Cardiovascular risk and increased plasma LDL cholesterol concentration: the role of the Regional Health ServiceThe relevance of hypercholesterolemia, as a risk factor for cardiovascular (CV) disease, requires urgent actions to detect and assist high-risk citizens/patients, thus reducing and/or avoiding future complications. This goal could be achieved through more widespread awareness of the problem within the Health System of the Veneto Region, joint efforts between clinical laboratories and clinicians in transmitting and interpreting informative laboratory reports, and deeper integration of hospital and community health services. Data from recent studies, recommendations of scientific societies and political-institutional guidelines helped in determining the number of patients in the Veneto Region, which may be suffering from clinical or biochemical conditions that impact on CV risk. These include hypercholesterolemia, which is particularly addressed in this paper, with special emphasis on FH (familial hypercholesterolemia), a chronic disease associated with very high CV risk

Compliance, persistence, costs and quality of life in young patients treated with antipsychotic drugs: results from the COMETA study

BACKGROUND: Little data is available on the real-world socio-economic burden and outcomes in schizophrenia. This study aimed to assess persistence, compliance, costs and Health-Related Quality-of-Life (HRQoL) in young patients undergoing antipsychotic treatment according to clinical practice. METHODS: A naturalistic, longitudinal, multicentre cohort study was conducted: we involved 637 patients aged 18–40 years, with schizophrenia or schizophreniform disorder diagnosed ≤10 years before, enrolled in 86 Italian Mental Health Centres and followed-up for 1 year. Comparisons were conducted between naïve (i.e., patients visiting the centre for the first time and starting a new treatment regimen) and non naïve patients. RESULTS: At enrolment, 84% of patients were taking atypical drugs, 3.7% typical, 10% a combination of the two classes, and 2% were untreated. During follow-up, 23% of patients switched at least once to a different class of treatment, a combination or no treatment. The mean Drug-Attitude-Inventory score was 43.4, with 94.3% of the patients considered compliant by the clinicians. On average, medical costs at baseline were 390.93€/patient-month, mostly for drug treatment (29.5%), psychotherapy (29.2%), and hospitalizations (27.1%). Patients and caregivers lost 3.5 days/patient-month of productivity. During follow-up, attitude toward treatment remained fairly similar, medical costs were generally stable, while productivity, clinical statusand HRQoL significantly improved. While no significantly different overall direct costs trends were found between naïve and non naïve patients, naïve patients showed generally a significant mean higher improvement of clinical outcomes, HRQoL and indirect costs, compared to the others. CONCLUSIONS: Our results suggest how tailoring the treatment strategy according to the complex and specific patient needs make it possible to achieve benefits and to allocate more efficiently resources. This study can also provide information on the most relevant items to be considered when conducting cost-effectiveness studies comparing specific alternatives for the treatment of target patients

Tracing ephemeral human occupation through archaeological, palaeoenvironmental and molecular proxies at Łabajowa Cave

Confirming ephemeral human occupation is a crucial issue in cave archaeology. The project ‘Tracing human presence in caves of Polish Jura’ focuses on the application of molecular methods to decode the history of past human activities in cave sediments in the Kraków-Częstochowa Upland. The results will be compared with archaeological and palaeoecological proxies

Compliance, persistence, costs and quality of life in young patients treated with antipsychotic drugs: Results from the COMETA study

Background: Little data is available on the real-world socio-economic burden and outcomes in schizophrenia. This study aimed to assess persistence, compliance, costs and Health-Related Quality-of-Life (HRQoL) in young patients undergoing antipsychotic treatment according to clinical practice.Methods: A naturalistic, longitudinal, multicentre cohort study was conducted: we involved 637 patients aged 18-40 years, with schizophrenia or schizophreniform disorder diagnosed ≤10 years before, enrolled in 86 Italian Mental Health Centres and followed-up for 1 year. Comparisons were conducted between naïve (i.e., patients visiting the centre for the first time and starting a new treatment regimen) and non naïve patients.Results: At enrolment, 84% of patients were taking atypical drugs, 3.7% typical, 10% a combination of the two classes, and 2% were untreated. During follow-up, 23% of patients switched at least once to a different class of treatment, a combination or no treatment. The mean Drug-Attitude-Inventory score was 43.4, with 94.3% of the patients considered compliant by the clinicians. On average, medical costs at baseline were 390.93€/patient-month, mostly for drug treatment (29.5%), psychotherapy (29.2%), and hospitalizations (27.1%). Patients and caregivers lost 3.5 days/patient-month of productivity. During follow-up, attitude toward treatment remained fairly similar, medical costs were generally stable, while productivity, clinical statusand HRQoL significantly improved. While no significantly different overall direct costs trends were found between naïve and non naïve patients, naïve patients showed generally a significant mean higher improvement of clinical outcomes, HRQoL and indirect costs, compared to the others.Conclusions: Our results suggest how tailoring the treatment strategy according to the complex and specific patient needs make it possible to achieve benefits and to allocate more efficiently resources. This study can also provide information on the most relevant items to be considered when conducting cost-effectiveness studies comparing specific alternatives for the treatment of target patients

The Mousterian lithic assemblage of the Ciota Ciara cave (Piedmont, Northern Italy): Exploitation and conditioning of raw materials

The Ciota Ciara cave is situated in Monte Fenera’s karst (Borgosesia – Vercelli), at 670 metres above sea level. It is the most important evidence of a Middle Palaeolithic settlement in Piedmont: the cave was used by Homo neanderthalensis during the OIS 5, in a mild-humid period, as proven by faunal remains. The environment was characterized by deciduous woodland and glades. The intersection between different habitats, the presence of lithic raw materials, the karst morphology and water sources were certainly the main factors that encouraged human settlement during the Upper Pleistocene period, between 80.000 and 70.000 BP.In 2009 systematic excavations began in the cave by the University of Ferrara, in partnership with the Soprintendenza per i Beni Archeologici del Piemonte e del Museo di Antichità Egizie. Research focused on the cave’s atrium where three stratigraphic units were investigated: 13, 103 and 14.The exploited raw materials’ characterization were made by the stereo-microscope observations and through the SEM (Scanning Electron Microscope). Several lithologies are represented in different proportion: quartz is the predominant exploited raw material, followed by spongolite, sandstone, mylonite and opal. The archaeological record consists of various typologies of quartz: macro-crystalline pegmatite quartz, micro-crystalline pegmatite quartz and hyaline quartz. All these types of raw materials have been found in the proximity of the archaeological site, within 5 km range.The lithic assemblage is made of flakes, retouched tools, cores and debris. The raw materials exploitation was achieved through the direct percussion technique with various methods: S.S.D.A., discoid and Levallois. The reduction sequences on quartz are complete, although no refitting was found. The reduction sequence is not complete for most part of the other raw materials. The débitage products are small-medium size (1-4 cm) and have different morphologies.The use-wear analysis on quartz’s artefacts was carried out using the low power approach. The preservation state of the lithic assemblage is very good and no chemical, mechanical or post-depositional alterations are evident. The use-wear analysis shows a predominance of medium-hard and medium-soft materials processing.The lithic industries characteristics show the production strategies adaptation typical of the Middle Palaeolithic to the characteristics of the non-sedimentary raw materials

FIB-SEM investigation and uniaxial compression of flexible graphite

Flexible graphite (FG) with 1 - 1.2 g/cm$^3$ density is employed as beam energy absorber material in the CERN's Large Hadron Collider (LHC) beam dumping system. However, the increase of energy deposited expected for new HL-LHC (High-Luminosity LHC) design demanded for an improvement in reliability and safety of beam dumping devices, and the need for a calibrated material model suitable for high-level FE simulations has been prioritized. This work sets the basic knowledge to develop a material model for FG suitable to this aim. A review of the FG properties available in literature is first given, followed by FIB-SEM (Focused Ion Beam - Scanning Electron Microscopy) microstructure investigation and monotonic and cyclic uniaxial compression tests. Similarities with other well-known groups of materials such as crushable foams, crumpled materials and compacted powders have been discussed. A simple 1D phenomenological model has been used to fit the experimental stress-strain curves and the accuracy of the result supports the assumptions that the graphite-like microstructure and the crumpled meso-structure play the major role under out-of-plane uniaxial compression.Comment: Pre-print template, 57 pages, 14 figure