Liver Illness and Psoriatic Patients

Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world's population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: Viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases

Highly damped quasinormal modes of Kerr black holes

Motivated by recent suggestions that highly damped black hole quasinormal modes (QNM's) may provide a link between classical general relativity and quantum gravity, we present an extensive computation of highly damped QNM's of Kerr black holes. We do not limit our attention to gravitational modes, thus filling some gaps in the existing literature. The frequency of gravitational modes with l=m=2 tends to \omega_R=2 \Omega, \Omega being the angular velocity of the black hole horizon. If Hod's conjecture is valid, this asymptotic behaviour is related to reversible black hole transformations. Other highly damped modes with m>0 that we computed do not show a similar behaviour. The real part of modes with l=2 and m<0 seems to asymptotically approach a constant value \omega_R\simeq -m\varpi, \varpi\simeq 0.12 being (almost) independent of a. For any perturbing field, trajectories in the complex plane of QNM's with m=0 show a spiralling behaviour, similar to the one observed for Reissner-Nordstrom (RN) black holes. Finally, for any perturbing field, the asymptotic separation in the imaginary part of consecutive modes with m>0 is given by 2\pi T_H (T_H being the black hole temperature). We conjecture that for all values of l and m>0 there is an infinity of modes tending to the critical frequency for superradiance (\omega_R=m) in the extremal limit. Finally, we study in some detail modes branching off the so--called ``algebraically special frequency'' of Schwarzschild black holes. For the first time we find numerically that QNM multiplets emerge from the algebraically special Schwarzschild modes, confirming a recent speculation.Comment: 19 pages, 11 figures. Minor typos corrected. Updated references to take into account some recent development

Do master narratives change among High School Students?: a characterization of how national history is represented

Master narratives frame students’ historical knowledge, possibly hindering access to more historical representations. A detailed analysis of students’ historical narratives about the origins of their own nation is presented in terms of four master narrative characteristics related to the historical subject, national identification, the main theme and the nation concept. The narratives of Argentine 8th and 11th graders were analyzed to establish whether a change toward a more complex historical account occurred. The results show that the past is mostly understood in master narrative terms but in the 11th grade narratives demonstrate a more historical understanding. Only identification appears to be fairly constant across years of history learning. The results suggest that in history education first aiming at a constructivist concept of nation and then using the concept to reflect on the national historical subject and events in the narrative might help produce historical understanding of a national past.This article was written with the support of projects EDU-2010-17725 (DGICYT, Spain) and PICT-2008-1217 (ANPCYT, Argentina), coordinated by the first author. We are grateful for that support

Galaxy bulges and their massive black holes: a review

With references to both key and oft-forgotten pioneering works, this article starts by presenting a review into how we came to believe in the existence of massive black holes at the centres of galaxies. It then presents the historical development of the near-linear (black hole)-(host spheroid) mass relation, before explaining why this has recently been dramatically revised. Past disagreement over the slope of the (black hole)-(velocity dispersion) relation is also explained, and the discovery of sub-structure within the (black hole)-(velocity dispersion) diagram is discussed. As the search for the fundamental connection between massive black holes and their host galaxies continues, the competing array of additional black hole mass scaling relations for samples of predominantly inactive galaxies are presented.Comment: Invited (15 Feb. 2014) review article (submitted 16 Nov. 2014). 590 references, 9 figures, 25 pages in emulateApJ format. To appear in "Galactic Bulges", E. Laurikainen, R.F. Peletier, and D.A. Gadotti (eds.), Springer Publishin

Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat

We have previously shown that, after acute administration, antidepressant drugs exert anti-inflammatory actions in rats. In this study we evaluated the effects of 3 different doses of chlomipramine (10, 20, and 40 mg/kg i.p), and fluoxetine (5.0, 10, and 20 mg/kg i.p.) on subcutaneous carrageenin-induced inflammation. Both drugs dose-dependently reduced the inflammatory exudate, as well as the PGE2-like bio- and immunoactivity in the exudate. Chlomipramine dose-dependently reduced substance P concentrations in the exudate, whereas fluoxetine was effective only at the highest dose. Our results confirm that antidepressant drugs are able to reduce the development of inflammation in the rat and suggest that the inhibition of substance P production might play a role in mediating the anti-inflammatory effects of chlomipramine

Carbamazepine exerts anti-inflammatory effects in the rat

In a first set of experiments, we evaluated the effects of different doses (5.0, 10, 20 and 40 mg/kg p.o.) of carbamazepine on nociceptive thresholds to thermal and mechanical stimuli, and on paw inflammatory hyperalgesia induced by the injection of brewer's yeast. Moreover, we studied the effect of carbamazepine on paw inflammatory edema by plethysmometry. Carbamazepine did not modify nociceptive latencies, but dose dependently reduced the hyperalgesia and the edema induced by the brewer's yeast injection in the rat hindpaw. In a second set of experiments, we studied the effects induced by the same doses of the drug on subcutaneous carrageenin-induced inflammation. Carbamazepine dose dependently reduced the inflammatory exudate, the prostaglandin E2-like activity in the exudate, and the substance P concentrations in the exudate. Our results demonstrate that carbamazepine is able to inhibit the development of different types of inflammation in the rat