72 research outputs found

    In vivo evaluation of a hybrid nanoparticle for molecular imaging of amyloid aggregation

    Get PDF
    International audienceAmyloid-β (Aβ) fibrillization is described as a central event in the pathogenesis of Alzheimer’s disease (AD). Amyloid imaging is expected to play a pivotal role in early and differential diagnosis of dementias, and in the evaluation of anti-Aβ treatments. Luminescent conjugated oligothiophenes (LCO) have been proposed as optical biomarkers of protein fibrillation [1]. In this paper, we evaluated a fluorescent magnetic hybrid nanoprobe (HNP5011), based on gadolinium fluoride nanoparticles functionalized with luminescent conjugated polythiophenes moieties (Fig. 1). The aim of this study was to investigate its potential for molecular imaging in a rat model bearing intracerebral pre-aggregated Aβ peptides

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

    Get PDF

    Contrast-enhanced ultrasound: a new method for TIPS follow-up

    No full text
    International audienc

    Contrast-enhanced ultrasound: a new method for TIPS follow-up

    No full text
    International audienc

    INFLAM - INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation

    No full text
    International audienceBackground: Inflammation is a share process in atherosclerosis and stroke and is thought to be a key player in the evolution of these diseases. Ten years ago, inflammation imaging with magnetic resonance imaging (MRI) was considered very promising for both pre-clinical and clinical studies of atherosclerosis and stroke. Contribution: We report here contributions to the field of inflammation imaging with USPIO-enhanced MRI. The goal was to investigate the life cycle of USPIOs in the body, and how the MRI signal has been impacted during their bio-interactions and bioprocessing. Those mechanisms were applied to pre-clinical longitudinal studies of inflammation in atherosclerosis and at the acute stage of ischemic stroke thus allowing the monitoring of treatment effects. Conclusion: This review presents the contribution of the collaborative research project under the "TecSan" grant from the French Research Agency (ANR) as well as pre-clinical and clinical perspectives of USPIO's inflammation MRI in atherosclerosis and stroke. (C) 2018 Published by Elsevier Masson SAS on behalf of AGBM

    Malignant pleural mesothelioma with osteoblastic heterologous elements: CT and MR imaging findings

    No full text
    [DOI:\hrefhttps://dx.doi.org/10.2214/ajr.178.4.178094910.2214/ajr.178.4.1780949] [PubMed:\hrefhttps://www.ncbi.nlm.nih.gov/pubmed/1190688011906880

    High-resolution MRI: detection of a culprit plaque after recurrent thrombolysis

    No full text
    [DOI:\hrefhttps://dx.doi.org/10.1007/s00415-015-7915-010.1007/s00415-015-7915-0] [PubMed:\hrefhttps://www.ncbi.nlm.nih.gov/pubmed/1167334511673345
    • …
    corecore