5,360 research outputs found

    WHO expert committees and key concepts for drugs, alcohol and tobacco, 1949-2013

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    Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

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    We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable

    Addiction through the Ages: a review of the development of concepts and ideas about addiction in European countries since the nineteenth century and the role of international organisations in the process

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    The work on addiction through the ages proceeded through 4 interlinked studies: The emergence of concepts of addiction across Europe at the national level, 1860-1980 The framing of the alcohol question at the international alcohol conferences The role of the World Health Organisation (WHO) and its expert committees in defining addiction from the 1940s to the early twenty first century The role of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in defining concepts of addiction The long view of addiction concepts at the country level over time points to continuities and changes across countries. They have also played a significant role in international organisations, the pre World War Two alcohol conferences and the World Health Organisation (WHO) after that war. The European level through the European Monitoring Centre on Drugs and Drug Addiction has also come into the picture in more recent times with discussion of a different set of concepts. Although a degree of stability has been achieved around addiction concepts, these still encapsulate a variety of meanings which translate into different treatment and policy approaches and traditions within Europe. By understanding the history of such concepts and how and why they came in and out of use, we can better understand addiction terminology and substance use policy today

    Partnerships: survey respondents' perceptions of inter-professional collaboration to address alcohol-related harms in England

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    Tackling alcohol-related harms crosses agency and professional boundaries, requiring collaboration between health, criminal justice, education and social welfare institutions. It is a key component of most multicomponent programmes in the United States, Australia and Europe. Partnership working, already embedded in service delivery structures, is a core mechanism for delivery of the new UK Government Alcohol Strategy. This article reports findings from a study of alcohol partnerships across England. The findings are based on a mix of open discussion interviews with key informants and on semi-structured telephone interviews with 90 professionals with roles in local alcohol partnerships. Interviewees reported the challenges of working within a complex network of interlinked partnerships, often within hierarchies under an umbrella partnership, some of them having a formal duty of partnership. The new alcohol strategy has emerged at a time of extensive reorganisation within health, social care and criminal justice structures. Further development of a partnership model for policy implementation would benefit from consideration of the incompatibility arising from required collaboration and from tensions between institutional and professional cultures. A clearer analysis of which aspects of partnership working provide ‘added value’ is needed

    Infiltrating history into the public health curriculum.

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    The insertion of history into the medical school curriculum has been discussed over a long period of time. But the role of history in the public health curriculum has not been the subject of much discussion, despite the changes in UK public health training and the advent of multidisciplinary public health. This article reviews the history of inserting history into the curriculum in a leading public health postgraduate institution. It discusses the strategies used to secure acceptance for history; the positioning of history within the curriculum both as a core and a special subject; and the different curriculum content and learning approaches which have been used over time. It reviews recent developments in distance learning and the launch of a history Massive Open On line Course. It concludes that no one approach can be recommended for inserting history and that flexibility, persistence, alliances and the willingness to adapt to local circumstances are important. Students themselves are now more receptive to historical approaches and can appreciate the value of a discipline which teaches critical skills of analysis and assessment of evidence. It remains to be discussed how the discipline and such approaches can be transferred into wider professional public health training and at the undergraduate level

    Search for Free Decay of Negative Pions in Water and Light Materials

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    We report on a search for the free decay component of pi- stopped in water and light materials. A non-zero value of this would be an indication of anomalous nu_e contamination to the nu_e and nu_mu_bar production at stopped-pion neutrino facilities. No free decay component of pi- was observed in water, Beryllium, and Aluminum, for which upper limits were established at 8.2E-4, 3.2E-3, and 7.7E-3, respectively

    Puente de Troy

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    En la pequeña provincia de Monmouth, en las proximidades de Gales, discurre el río Wye, sobre el que en 1876 se construyó un puente metálico, de tablero superior, dedicado al paso de una línea férrea
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