Political Ambition and Legislative Behavior in the European Parliament

Members of the European Parliament (MEP) typically follow one of two career paths, either advancing within the European Parliament itself or returning to higher office in their home states. We argue that these different ambitions condition legislative behavior. Specifically, MEPs seeking domestic careers defect from group-leadership votes more frequently and oppose legislation that expands the purview of supranational institutions. We show how individual, domestic-party, and national level variables shape the careers available to MEPs and, in turn, their voting choices. To test the argument, we analyze MEPs' roll-call voting behavior in the 5th session of the EP (1999-2004) using a random effects model that captures idiosyncrasies in voting behavior across both individual MEPs and specific roll-call votes.published or submitted for publicationnot peer reviewe

Seeing the arrow of time

URL to conference programWe explore whether we can observe Time’s Arrow in a temporal sequence–is it possible to tell whether a video is running forwards or backwards? We investigate this somewhat philosophical question using computer vision and machine learning techniques. We explore three methods by which we might detect Time’s Arrow in video sequences, based on distinct ways in which motion in video sequences might be asymmetric in time. We demonstrate good video forwards /backwards classification results on a selection of YouTube video clips, and on natively-captured sequences (with no temporally-dependent video compression), and examine what motions the models have learned that help discriminate forwards from backwards time.European Research Council (ERC grant VisRec no. 228180)National Basic Research Program of China (973 Program) (2013CB329503)National Natural Science Foundation (China) (NSFC Grant no. 91120301)United States. Office of Naval Research (ONR MURI grant N00014-09-1-1051)National Science Foundation (U.S.) (NSF CGV-1111415

Active eukaryotes in microbialites from Highborne Cay, Bahamas, and Hamelin Pool (Shark Bay), Australia

Author Posting. © The Author(s), 2013. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in The ISME Journal 8 (2014): 418–429, doi:10.1038/ismej.2013.130.Microbialites are organosedimentary structures that are formed through the interaction of benthic microbial communities and sediments and include mineral precipitation. These lithifying microbial mat structures include stromatolites and thrombolites. Exuma Sound in the Bahamas, and Hamelin Pool in Shark Bay, Western Australia are two locations where significant stands of modern microbialites exist. Although prokaryotic diversity in these structures is reasonably well documented, little is known about the eukaryotic component of these communities and their potential to influence sedimentary fabrics through grazing, binding and burrowing activities. Accordingly, comparisons of eukaryotic communities in modern stromatolitic and thrombolytic mats can potentially provide insight into the coexistence of both laminated and clotted mat structures in close proximity to one another. Here we examine this possibility by comparing eukaryotic diversity based on Sanger and high-throughput pyrosequencing of small subunit ribosomal RNA (18S rRNA) genes. Analyses were based on total RNA extracts as template to minimize input from inactive or deceased organisms. Results identified diverse eukaryotic communities particularly stramenopiles, Alveolata, Metazoa, Amoebozoa, and Rhizaria within different mat types at both locations, as well as abundant and diverse signatures of eukaryotes with <80% sequence similarity to sequences in GenBank. This suggests presence of significant novel eukaryotic diversity, particularly in hypersaline Hamelin Pool. There was evidence of vertical structuring of protist populations and foraminiferal diversity was highest in bioturbated/clotted thrombolite mats of Highborne Cay.This work was funded by grant OCE-0926421 to JMB and VPE and OCE-0926372 to RES

Averaging theory for description of environmental problems: What have we learned?

Advances in Water Resources has been a prime archival source for implementation of averaging theories in changing the scale at which processes of importance in environmental modeling are described. Thus in celebration of the 35th year of this journal, it seems appropriate to assess what has been learned about these theories and about their utility in describing systems of interest. We review advances in understanding and use of averaging theories to describe porous medium flow and transport at the macroscale, an averaged scale that models spatial variability, and at the megascale, an integral scale that only considers time variation of system properties. We detail physical insights gained from the development and application of averaging theory for flow through porous medium systems and for the behavior of solids at the macroscale. We show the relationship between standard models that are typically applied and more rigorous models that are derived using modern averaging theory. We discuss how the results derived from averaging theory that are available can be built upon and applied broadly within the community. We highlight opportunities and needs that exist for collaborations among theorists, numerical analysts, and experimentalists to advance the new classes of models that have been derived. Lastly, we comment on averaging developments for rivers, estuaries, and watersheds

Methamphetamine Induces Dopamine D1 Receptor-Dependent Endoplasmic Reticulum Stress-Related Molecular Events in the Rat Striatum

Methamphetamine (METH) is an illicit toxic psychostimulant which is widely abused. Its toxic effects depend on the release of excessive levels of dopamine (DA) that activates striatal DA receptors. Inhibition of DA-mediated neurotransmission by the DA D1 receptor antagonist, SCH23390, protects against METH-induced neuronal apoptosis. The initial purpose of the present study was to investigate, using microarray analyses, the influence of SCH23390 on transcriptional responses in the rat striatum caused by a single METH injection at 2 and 4 hours after drug administration. We identified 545 out of a total of 22,227 genes as METH-responsive. These include genes which are involved in apoptotic pathways, endoplasmic reticulum (ER) stress, and in transcription regulation, among others. Of these, a total of 172 genes showed SCH23390-induced inhibition of METH-mediated changes. Among these SCH23390-responsive genes were several genes that are regulated during ER stress, namely ATF3, HSP27, Hmox1, HSP40, and CHOP/Gadd153. The secondary goal of the study was to investigate the role of DA D1 receptor stimulation on the expression of genes that participate in ER stress-mediated molecular events. We thus used quantitative PCR to confirm changes in the METH-responsive ER genes identified by the microarray analyses. We also measured the expression of these genes and of ATF4, ATF6, BiP/GRP78, and of GADD34 over a more extended time course. SCH23390 attenuated or blocked METH-induced increases in the expression of the majority of these genes. Western blot analysis revealed METH-induced increases in the expression of the antioxidant protein, Hmox1, which lasted for about 24 hours after the METH injection. Additionally, METH caused DA D1 receptor-dependent transit of the Hmox1 regulator protein, Nrf2, from cytosolic into nuclear fractions where the protein exerts its regulatory functions. When taken together, these findings indicate that SCH23390 can provide protection against neuronal apoptosis by inhibiting METH-mediated DA D1 receptor-mediated ER stress in the rat striatum. Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain

Quantum teleportation using active feed-forward between two Canary Islands

Quantum teleportation [1] is a quintessential prerequisite of many quantum information processing protocols [2-4]. By using quantum teleportation, one can circumvent the no-cloning theorem [5] and faithfully transfer unknown quantum states to a party whose location is even unknown over arbitrary distances. Ever since the first experimental demonstrations of quantum teleportation of independent qubits [6] and of squeezed states [7], researchers have progressively extended the communication distance in teleportation, usually without active feed-forward of the classical Bell-state measurement result which is an essential ingredient in future applications such as communication between quantum computers. Here we report the first long-distance quantum teleportation experiment with active feed-forward in real time. The experiment employed two optical links, quantum and classical, over 143 km free space between the two Canary Islands of La Palma and Tenerife. To achieve this, the experiment had to employ novel techniques such as a frequency-uncorrelated polarization-entangled photon pair source, ultra-low-noise single-photon detectors, and entanglement-assisted clock synchronization. The average teleported state fidelity was well beyond the classical limit of 2/3. Furthermore, we confirmed the quality of the quantum teleportation procedure (without feed-forward) by complete quantum process tomography. Our experiment confirms the maturity and applicability of the involved technologies in real-world scenarios, and is a milestone towards future satellite-based quantum teleportation

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)

Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of L-{alpha}-aminoadipic semialdehyde/L-{Delta}1-piperideine 6-carboxylate. However, whilst this is a highly treatable disorder, there is general uncertainty about when to consider this diagnosis and how to test for it. This study aimed to evaluate the use of measurement of urine L-{alpha}-aminoadipic semialdehyde/creatinine ratio and mutation analysis of ALDH7A1 (antiquitin) in investigation of patients with suspected or clinically proven pyridoxine-dependent epilepsy and to characterize further the phenotypic spectrum of antiquitin deficiency. Urinary L-{alpha}-aminoadipic semialdehyde concentration was determined by liquid chromatography tandem mass spectrometry. When this was above the normal range, DNA sequencing of the ALDH7A1 gene was performed. Clinicians were asked to complete questionnaires on clinical, biochemical, magnetic resonance imaging and electroencephalography features of patients. The clinical spectrum of antiquitin deficiency extended from ventriculomegaly detected on foetal ultrasound, through abnormal foetal movements and a multisystem neonatal disorder, to the onset of seizures and autistic features after the first year of life. Our relatively large series suggested that clinical diagnosis of pyridoxine dependent epilepsy can be challenging because: (i) there may be some response to antiepileptic drugs; (ii) in infants with multisystem pathology, the response to pyridoxine may not be instant and obvious; and (iii) structural brain abnormalities may co-exist and be considered sufficient cause of epilepsy, whereas the fits may be a consequence of antiquitin deficiency and are then responsive to pyridoxine. These findings support the use of biochemical and DNA tests for antiquitin deficiency and a clinical trial of pyridoxine in infants and children with epilepsy across a broad range of clinical scenarios