81 research outputs found
Atazanavir and darunavir in pregnant women with HIV: Evaluation of laboratory and clinical outcomes from an observational national study
Background: Atazanavir and darunavir represent the main HIV PIs recommended in pregnancy, but comparativedata in pregnant women are limited.We assessed the safety and activity profile of these two drugs in pregnancyusing data from a national observational study.Methods: Women with atazanavir or darunavir exposure in pregnancy were evaluated for laboratory measuresand main pregnancy outcomes (e.g. preterm delivery, low birthweight, non-elective caesarean section and neonatalgestational age-adjusted birthweight Z-score).Results: Final analysis included 500 pregnancies with either atazanavir (n"409) or darunavir (n"91) exposure.No differences in pregnancy outcomes, weight gain in pregnancy, drug discontinuations, undetectable HIV-RNA,haemoglobin, ALT, total cholesterol, HDL cholesterol and LDL cholesterol were observed between the twogroups. At third trimester, exposure to darunavir was associated with higher levels of plasma triglycerides(median 235.5 versus 179 mg/dL; P"0.032) and a higher total cholesterol/HDL cholesterol ratio (median 4.03versus 3.27; P"0.028) and exposure to atazanavir was associated with higher levels of plasma bilirubin (1.54versus 0.32 mg/dL; P<0.001).Conclusions: In this observational study, the two main HIV PIs currently recommended by perinatal guidelinesshowed similar safety and activity in pregnancy, with no evidence of differences between the two drugs in termsof main pregnancy outcomes. Based on the minor differences observed in laboratory measures, prescribingphysicians might prefer either drug in some particular situations where the different impacts of treatment onlipid profile and bilirubin may have clinical relevance
Attachment, infidelity, and loneliness in college students involved in a romantic relationship: the role of relationship satisfaction, morbidity and prayer for partner
This study examined the mediating effects of relationship satisfaction, prayer
for a partner, and morbidity in the relationship between attachment and loneliness, infidelity
and loneliness, and psychological morbidity and loneliness, in college students
involved in a romantic relationship. Participants were students in an introductory course on
family development. This study examined only students (n = 345) who were involved in a
romantic relationship. The average age of participants was 19.46 (SD = 1.92) and 25 %
were males. Short-form UCLA Loneliness Scale (ULS-8), (Hays and DiMatteo in J Pers
Assess 51:69–81, doi:10.1207/s15327752jpa5101_6, 1987); Relationship Satisfaction
Scale (Funk and Rogge in J Fam Psychol 21:572–583, doi:10.1037/0893-3200.21.4.572,
2007); Rotterdam Symptom Checklist (De Haes et al. in Measuring the quality of life of
cancer patients with the Rotterdam Symptom Checklist (RSCL): a manual, Northern
Centre for Healthcare Research, Groningen, 1996); Prayer for Partner Scale, (Fincham
et al. in J Pers Soc Psychol 99:649–659, doi:10.1037/a0019628, 2010); Infidelity Scale,
(Drigotas et al. in J Pers Soc Psychol 77:509–524, doi:10.1037/0022-3514.77.3.509, 1999);
and the Experiences in Close Relationship Scale-short form (Wei et al. in J Couns Psychol
52(4):602–614, doi:10.1037/0022-0167.52.4.602, 2005). Results showed that relationship
satisfaction mediated the relationship between avoidance attachment and loneliness and
between infidelity and loneliness. Physical morbidity mediated the relationship between
anxious attachment and psychological morbidity. Psychological morbidity mediated the
relationship between anxious attachment and physical morbidity. The present results
expand the literature on attachment by presenting evidence that anxious and avoidant partners experience loneliness differently. Implications for couple’s therapy are addressed.
Future research should replicate these results with older samples and married couples.Acknowledgments This research was supported by Grant Number 90FE0022 from the United States
Department of Health and Human Services awarded to the last author
Mesoporous ZSM-5 Zeolites in Acid Catalysis: Top-Down vs. Bottom-Up Approach
A top-down desilication of Al-rich ZSM-5 zeolites and a bottom-up mesopores creating method were evaluated in this study. Three liquid–solid and one gas–solid heterogeneously-catalysed reactions were chosen to establish relationships between zeolites textural properties and their catalytic behavior in acid-catalysed model reactions that are influenced by shape selectivity: Diels-Alder cyclization between isoprene and methylacrylate, Methanol-to-Olefins (MTO) reaction, chlorination of iodobenzene with trichloroisocyanuric acid (TCCA), and Friedel-Crafts acylation of anisole by carboxylic acids with differing sizes. It is found amongst others that no optimal mesoporosity for all the different reactions can be easily obtained, but depending on the chosen application, a specific treatment has to be set to achieve high activity/selectivity and stability
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