A Statistical Semi-Empirical Model: Satellite galaxies in Groups and Clusters

We present STEEL a STatistical sEmi-Empirical modeL designed to probe the distribution of satellite galaxies in groups and clusters. Our fast statistical methodology relies on tracing the abundances of central and satellite haloes via their mass functions at all cosmic epochs with virtually no limitation on cosmic volume and mass resolution. From mean halo accretion histories and subhalo mass functions the satellite mass function is progressively built in time via abundance matching techniques constrained by number densities of centrals in the local Universe. By enforcing dynamical merging timescales as predicted by high-resolution N-body simulations, we obtain satellite distributions as a function of stellar mass and halo mass consistent with current data. We show that stellar stripping, star formation, and quenching play all a secondary role in setting the number densities of massive satellites above $M_*\gtrsim 3\times 10^{10}\, M_{\odot}$. We further show that observed star formation rates used in our empirical model over predict low-mass satellites below $M_*\lesssim 3\times 10^{10}\, M_{\odot}$, whereas, star formation rates derived from a continuity equation approach yield the correct abundances similar to previous results for centrals.Comment: 21 pages, 17 Figures. MNRAS, in pres

Comparing PyMorph and SDSS photometry. II. The differences are more than semantics and are not dominated by intracluster light

The Sloan Digital Sky Survey pipeline photometry underestimates the brightnesses of the most luminous galaxies. This is mainly because (i) the SDSS overestimates the sky background and (ii) single or two-component Sersic-based models better fit the surface brightness profile of galaxies, especially at high luminosities, than does the de Vaucouleurs model used by the SDSS pipeline. We use the PyMorph photometric reductions to isolate effect (ii) and show that it is the same in the full sample as in small group environments, and for satellites in the most massive clusters as well. None of these are expected to be significantly affected by intracluster light (ICL). We only see an additional effect for centrals in the most massive halos, but we argue that even this is not dominated by ICL. Hence, for the vast majority of galaxies, the differences between PyMorph and SDSS pipeline photometry cannot be ascribed to the semantics of whether or not one includes the ICL when describing the stellar mass of massive galaxies. Rather, they likely reflect differences in star formation or assembly histories. Failure to account for the SDSS underestimate has significantly biased most previous estimates of the SDSS luminosity and stellar mass functions, and therefore Halo Model estimates of the z ~ 0.1 relation between the mass of a halo and that of the galaxy at its center. We also show that when one studies correlations, at fixed group mass, with a quantity which was not used to define the groups, then selection effects appear. We show why such effects arise, and should not be mistaken for physical effects.Comment: 15 pages, 17 figures, accepted for publication in MNRAS. The PyMorph luminosities and stellar masses are available at https://www.physics.upenn.edu/~ameert/SDSS_PhotDec

Direct Calorimetric Studies on the Heats of Ionization of Oxygenated and Deoxygenated Hemoglobin

Abstract The total heats of ionization, Qo and Qr, of bovine, human, and horse oxygenated and deoxygenated hemoglobin (O2Hb and Hb) have been directly measured by the rapid calorimetric method over the pH range from 5.7 to 9.0, at 12–28°. The most extensive determinations have been those on bovine hemoglobin: above about pH 6.6 the thermal titration curve for Hb lies systematically above that for O2Hb by about 600 cal, this difference presisting practically unchanged up to the most alkaline pH (8.7) studied. The two thermal titration curves cross at approximately pH 6.3, below which the O2Hb curve lies above the Hb curve by an increasing amount (up to 1,000 cal). The fact that Qr remains greater than Qo at pH 8.7, at which the absolute value of Qr is about 11,000 cal, implies that the heme-linked group, which ionizes in this pH range in the case of Hb, must have a heat of ionization, Qr, of around 11,000 cal. This figure, which was confirmed by an approximate method of calculation, lies outside the range usually attributed to the heat of ionization of imidazole or its derivatives. There is some indication, from a comparison of the difference between the two thermal titration curves for human Hb and O2Hb at approximately pH 7.3, that (Qr - Qo) is of the order of 4,000 cal, Qo being the heat of ionization of the corresponding heme-linked group in O2Hb. The results thus support the conclusions reached in the adjoining paper by Rossi-Bernardi and Roughton on the effect of temperature on the oxygen-linked ionizations of hemoglobin. The relation of the present studies to the cognate effects of pH on the heat of oxygenation of hemoglobin is briefly indicated

Cooperation between Prostaglandin E2 and Epidermal Growth Factor Receptor in Cancer Progression: A Dual Target for Cancer Therapy

It is recognized that prostaglandin E2 (PGE2) is one key lipid mediator involved in chronic inflammation, and it is directly implicated in tumor development by regulating cancer cell growth and migration, apoptosis, epithelial–mesenchymal transition, angiogenesis, and immune escape. In addition, the expression of the enzymes involved in PGE2 synthesis, cyclooxygenase 2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES1), positively correlates with tumor progression and aggressiveness, clearly indicating the crucial role of the entire pathway in cancer. Moreover, several lines of evidence suggest that the COX2/mPGES1/PGE2 inflammatory axis is involved in the modulation of epidermal growth factor receptor (EGFR) signaling to reinforce the oncogenic drive of EGFR activation. Similarly, EGFR activation promotes the induction of COX2/mPGES1 expression and PGE2 production. In this review, we describe the interplay between COX2/mPGES1/PGE2 and EGFR in cancer, and new therapeutic strategies that target this signaling pathway, to outline the importance of the modulation of the inflammatory process in cancer fighting. © 2023 by the authors

Asymmetric Organocatalysis-A Powerful Technology Platform for Academia and Industry: Pregabalin as a Case Study

Enantioselective organocatalysis has quickly established itself as the third pillar of asymmetric catalysis. It is a powerful technology platform, and it has a tremendous impact in both academic and industrial settings. By focusing on pregabalin, as a case study, this Perspective aims to show how a process amenable to industry of a simple chiral molecule can be tackled in several different ways using organocatalysis

The high mass end of the stellar mass function: Dependence on stellar population models and agreement between fits to the light profile

We quantify the systematic effects on the stellar mass function which arise from assumptions about the stellar population, as well as how one fits the light profiles of the most luminous galaxies at z ~ 0.1. When comparing results from the literature, we are careful to separate out these effects. Our analysis shows that while systematics in the estimated comoving number density which arise from different treatments of the stellar population remain of order < 0.5 dex, systematics in photometry are now about 0.1 dex, despite recent claims in the literature. Compared to these more recent analyses, previous work based on Sloan Digital Sky Survey (SDSS) pipeline photometry leads to underestimates of rho_*(> M_*) by factors of 3-10 in the mass range 10^11 - 10^11.6 M_Sun, but up to a factor of 100 at higher stellar masses. This impacts studies which match massive galaxies to dark matter halos. Although systematics which arise from different treatments of the stellar population remain of order < 0.5 dex, our finding that systematics in photometry now amount to only about 0.1 dex in the stellar mass density is a significant improvement with respect to a decade ago. Our results highlight the importance of using the same stellar population and photometric models whenever low and high redshift samples are compared.Comment: 18 pages, 17 figures, accepted for publication in MNRAS. The PyMorph luminosities and stellar masses are available at https://www.physics.upenn.edu/~ameert/SDSS_PhotDec

Crustal Velocity Structure in Italy from Analysis of Regional Seismic Waveforms

In this paper, we use regional seismic waveforms recorded by the recently-installed Istituto Nazionale di Geofisica e Vulcanologia (INGV) national network and the Mediterranean Very Broadband Seismographic Network (MedNet) stations to develop one-dimensional (1-D) crustal velocity models for the Italian peninsula. About 55,000 P -wave and 35,000 S -wave arrival times from 4,727 events are used to derive average seismic parameters in the crust and uppermost mantle. We define four regions, according to geological constraints and recent travel-time tomography results. Based on the average seismic parameters, we combine broadband seismic waveforms and travel-times of regional phases to model crustal structures for the four regions by applying the genetic algorithm. Our results indicate smooth velocity gradients with depth beneath the Apennines, and a deep Moho beneath the central Alps. Green’s functions from the regionalized 1-D velocity models are used to determine source depths and focal mechanisms for 37 events with magnitude larger than 3.5 by a grid search technique. Our results show that normal and strike-slip faulting source mechanisms dominate the Apenninic belt and most thrust faulting events occur in the Adriatic sea and the outer margin of the northern Apennines

The Influence of Quadrature Errors on Isogeometric Mortar Methods

Mortar methods have recently been shown to be well suited for isogeometric analysis. We review the recent mathematical analysis and then investigate the variational crime introduced by quadrature formulas for the coupling integrals. Motivated by finite element observations, we consider a quadrature rule purely based on the slave mesh as well as a method using quadrature rules based on the slave mesh and on the master mesh, resulting in a non-symmetric saddle point problem. While in the first case reduced convergence rates can be observed, in the second case the influence of the variational crime is less significant

Meta-analysis on the Effect of Mild Primary Hyperparathyroidism and Parathyroidectomy upon Arterial Stiffness

Context: Current data about the cardiovascular manifestations of mild primary hyperparathyroidism (pHPT) are often conflicting. Pulse wave velocity (PWV) is the gold standard for assessing aortic stiffness, and it predicts cardiovascular morbidity and mortality. Objective: Primary outcomes were to investigate if mild pHPT was associated with higher PWV and if parathyroidectomy (PTX) reduced PWV in mild pHPT. Secondary outcome was to investigate blood pressure changes after PTX. Methods: Sources were PubMed, Google Scholar, SCOPUS, Web of Science, and the Cochrane Library. Eligible studies included reports of PWV in patients with mild pHPT and controls, or in patients with mild pHPT before and after PTX. Two investigators independently identified eligible studies and extracted data. Pooled mean difference (MD) was the summary effect measure. Data were presented in forest plots with outlier and influential case diagnostics. Nine observational studies and one randomized clinical trial were selected, including 433 patients with mild pHPT, 171 of whom underwent PTX, and 407 controls. PWV was significantly higher in mild pHPT than in controls (MD = 1.18, 0.67 to 1.68, P <. 0001). Seven studies evaluated the effect of PTX on PWV. PTX significantly reduced PWV (MD =-0.48,-0.88 to-0.07, P =. 022). Conclusion: Aortic stiffness is increased in patients with mild pHPT, supporting the notion that mild pHPT is also associated with adverse cardiovascular manifestations. PTX significantly reduced arterial stiffness in mild pHPT, indicating that the benefit of PTX over cardiovascular manifestations should not be dismissed but it deserves further studies