Automatic Rigid Registration of Aortic Aneurysm Arterial System

An abdominal aortic aneurysm is defined as a local and abnormal dilation of the aortic wall that can lead to rupture and death without treatment. A useful tool for the patient's postoperative follow-up is segmentation registration to see the evolution of the aneurysm between two examinations. Here, we propose a method to automatically register the entire arterial system: the segmentation is divided in three parts (suprarenal, infrarenal zone, and iliac arteries) and each part is registered separately. We chose a rigid point set to point set registration through the iterative closest point algorithm. We also compute the displacement fields and derive a criterion to accept or reject the registration of the infrarenal zone and iliac arteries. Registration is successful in 96% of cases for the infrarenal zone, in 94% for the suprarenal zone and in 65% for the iliac arteries

La Silla del Papa (Tarifa, Cádiz) : aux origines de Baelo Claudia

International audienceCompte rendu de la campagne de fouille de 2007 à La Silla del Papa (Tarifa, Cádiz

On the use of utility functions for optimizing phase II/phase III seamless trial designs

Background: For several years adaptive designs became more and more popular in the pharmaceutical industry and in particular much attention was brought on adaptive seamless designs. Those designs combine the phase II dose finding trial and the phase III confirmatory trial in a single protocol (with a fixed total sample size). The objective of this paper is to propose some utility-based tools to optimize those designs: first in terms of ratio between phase II and phase III sample sizes, and, second, in patient allocation to doses at the beginning of phase II. Methods: Design optimization methods are generally based either on Fisher information matrix (D-optimality) or on the variance of some statistics of interest (C-optimality). Instead, we propose to define utility functions associated to sponsors' decision related to choice of dose for the phase III and we propose design optimization metrics based on the expected value of this utility. Results and Conclusions: After reviewing and discussing several kinds of utility functions, we focused on two of them, that we have assessed through simulations. We concluded that in most of the scenarios simulated, the expected utility was in a sense more sensitive to the timing of the interim analysis (ratio between phase II over total sample size) than on the patients allocation between the doses. This result points out the fact that it might be necessary to enroll a larger number of patients in phase II to allow an accurate identification of the optimal dose

Borja Díaz Ariño, Epigrafía latina republicana de Hispania

L’ouvrage correspond à la version publiée de la thèse de doctorat soutenue par Borja Díaz Ariño en février 2007 à l’université de Saragosse. Ce recueil, qui a reçu le prix de l’Association internationale d’épigraphie grecque et latine, représente un outil de travail précieux pour les historiens et protohistoriens de la péninsule Ibérique travaillant sur les deux derniers siècles avant notre ère. En plus d’être d’une excellente tenue scientifique, cet ouvrage manifeste une volonté d’exhaustivi..

L’Imperium avant l’Empire

Au tournant de notre ère, la représentation géographique que possèdent les Romains de l’Extrême Occident est assez précise : elle reflète la mainmise politique, certes récente, mais réelle, de la puissance romaine sur les espaces du détroit de Gibraltar. À l’extrême fin de la République, le pouvoir romain a commencé à transformer et adapter les infrastructures de transport pour pouvoir encore accroître et faciliter sa domination politique. Il faut expliquer à présent l’origine et les causes d..

Qui a tué Marcellus ? Hiérarchie administrative et prosopographie à travers le procès de Marcel le Centurion (298 p. C.)

International audienc