IMUNOPATOGÃ?NESE DA ALERGIA A PROTEÃNAS DO LEITE DE BOVINOS

Resumo: a alergia a proteína do leite de bovinos (APLB) é uma enfermidade comum em crianças predispostas apresentando a sua etiopatogenia mediada por mecanismos imunológicos. A APLB causa complicações que comprometem a qualidade de vida dos pacientes. Esta revisão abordará os principais fatores e mecanismos imunológicos envolvidos nesta reação adversa a alimento possibilitando um melhor entendimento da imunopatogênese da doença. Palavras-chave: Alergia. Proteína do leite. Crianças. Imunopatogênese. Qualidade de vida

Hand Function in Muscular Dystrophies: Relationship Between Performance of Upper Limb and Jebsen-Taylor Tests

The aim of this study was to investigate the relationship between Performance of Upper Limb (PUL) and Jebsen-Taylor Test (JTT) to assess and monitor upper limb function progression in patients with muscular dystrophy. Thirty patients diagnosed with Duchenne muscular dystrophy, limb-girdle muscular dystrophy, Becker muscular dystrophy, myotonic dystrophy Type 1, and fascioscapulohumeral dystrophy were submitted to the shoulder, elbow, and wrist domains of PUL, and to JTT subtests. Spearman tests investigated the relationships between PUL and JTT total scores and domains. Correlations were classified as strong (r >= 0.70), moderate (0.40 <= r < 0.70), or weak (r <= 0.40). There were strong correlations between the PUL and JTT total scores (r= -0.706). Although JTT measures time and PUL provides kinesiologic scores, these measures were related. Therefore, muscle synergies, which control the compensatory movements and motor functions involving mainly shoulder, elbow, wrist, and finger movements, are related to timed performance in patients with muscular dystrophies.Univ Sao Paulo, Sch Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Human Movement Sci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol Neurosurg, Sao Paulo, BrazilUniv Sao Paulo, Dept Neurol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Human Movement Sci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol Neurosurg, Sao Paulo, BrazilUniv Sao Paulo, Dept Neurol, Sao Paulo, BrazilWeb of Scienc

Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis

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