3,785 research outputs found
Arendt and political realism: towards a realist account of political judgement
This article argues that Hannah Arendtâs thought can offer significant insights on political judgement for realism in political theory. We identify a realist position which emphasises the need to account for how humans judge politically, contra moralist tendencies to limit its exercise to rational standards, but which fails to provide a sufficient conception of its structure and potential. Limited appeals to political judgement render the realist defence of the political elusive, and compromise the endeavour to offer a meaningful alternative to the moralist tendency to displace politics. The potential and limitations of realist discussions on judgement are made visible in relation to proto-realists Judith Shklar and Isaiah Berlin.
In seeking to enrich the realist conception of the political, the article introduces the displacement critique found in the neglected Arendtian ârealismâ. It also provides the foundations for a distinctly realist account of political judgement which, we argue, requires elaboration along two dimensions: the social coding of political judgement and the political capacities that help judgement build a suitable political sphere
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Medical students as global citizens: a qualitative study of medical students' views on global health teaching within the undergraduate medical curriculum
Background: There is increasing interest in global health teaching among medical schools and their students. Schools in the UK and internationally are considering the best structure, methods and content of global health courses. Academic work in this area, however, has tended to either be normative (specifying what global health teaching ought to look like) or descriptive (of a particular intervention, new module, elective, etc.).
Methods: While a number of studies have explored student perspectives on global health teaching, these have often relied on tools such as questionnaires that generate little in-depth evidence. This study instead used qualitative methods to explore medical student perspectives on global health in the context of a new global health module established in the core medical curriculum at a UK medical school.
Results: Fifth year medical students participated in a structured focus group session and semi-structured interviews designed to explore their knowledge and learning about global health issues, as well as their wider perspectives on these issues and their relevance to professional development. While perspectives on global health ranged from global health âadvocateâ to âscepticâ, all of the students acknowledged the challenges of prioritising global health within a busy curriculum.
Conclusions: Students are highly alert to the diverse epistemological issues that underpin global health. For some students, such interdisciplinarity is fundamental to understanding contemporary health and healthcare. For others, global health is merely a topic of geographic relevance. Furthermore, some students appeared to accept global health as a specialist area only relevant to professionals working overseas, while others considered it to be an essential part of working in the globalised world and therefore relevant to all medical professionals. Students also clearly noted that including âsoftâ subjects and more discursive approaches to teaching and learning often sits awkwardly in a programme where âharderâ forms of knowledge and didactic methods tend to dominate. This suggests that more work needs to be done to explain the relevance of global health to medical students at the very beginning of their studies
How much do we really lose?âYield losses in the proximity of natural landscape elements in agricultural landscapes
Natural landscape elements (NLEs) in agricultural landscapes contribute to biodiversity and ecosystem services, but are also regarded as an obstacle for largeâscale agricultural production. However, the effects of NLEs on crop yield have rarely been measured. Here, we investigated how different bordering structures, such as agricultural roads, fieldâtoâfield borders, forests, hedgerows, and kettle holes, influence agricultural yields. We hypothesized that (a) yield values at field borders differ from midâfield yields and that (b) the extent of this change in yields depends on the bordering structure.
We measured winter wheat yields along transects with logâscaled distances from the border into the agricultural field within two intensively managed agricultural landscapes in Germany (2014 near Göttingen, and 2015â2017 in the Uckermark).
We observed a yield loss adjacent to every investigated bordering structure of 11%â38% in comparison with midâfield yields. However, depending on the bordering structure, this yield loss disappeared at different distances. While the proximity of kettle holes did not affect yields more than neighboring agricultural fields, woody landscape elements had strong effects on winter wheat yields. Notably, 95% of midâfield yields could already be reached at a distance of 11.3 m from a kettle hole and at a distance of 17.8 m from hedgerows as well as forest borders.
Our findings suggest that yield losses are especially relevant directly adjacent to woody landscape elements, but not adjacent to inâfield water bodies. This highlights the potential to simultaneously counteract yield losses close to the field border and enhance biodiversity by combining different NLEs in agricultural landscapes such as creating strips of extensive grassland vegetation between woody landscape elements and agricultural fields. In conclusion, our results can be used to quantify ecocompensations to find optimal solutions for the delivery of productive and regulative ecosystem services in heterogeneous agricultural landscapes
Exact norm-conserving stochastic time-dependent Hartree-Fock
We derive an exact single-body decomposition of the time-dependent
Schroedinger equation for N pairwise-interacting fermions. Each fermion obeys a
stochastic time-dependent norm-preserving wave equation. As a first test of the
method we calculate the low energy spectrum of Helium. An extension of the
method to bosons is outlined.Comment: 21 pages, 3 figures, LaTeX fil
Polarised target for Drell-Yan experiment in COMPASS at CERN, part I
In the polarised Drell-Yan experiment at the COMPASS facility in CERN pion
beam with momentum of 190 GeV/c and intensity about pions/s interacted
with transversely polarised NH target. Muon pairs produced in Drel-Yan
process were detected. The measurement was done in 2015 as the 1st ever
polarised Drell-Yan fixed target experiment. The hydrogen nuclei in the
solid-state NH were polarised by dynamic nuclear polarisation in 2.5 T
field of large-acceptance superconducting magnet. Large helium dilution
cryostat was used to cool the target down below 100 mK. Polarisation of
hydrogen nuclei reached during the data taking was about 80 %. Two oppositely
polarised target cells, each 55 cm long and 4 cm in diameter were used.
Overview of COMPASS facility and the polarised target with emphasis on the
dilution cryostat and magnet is given. Results of the polarisation measurement
in the Drell-Yan run and overviews of the target material, cell and dynamic
nuclear polarisation system are given in the part II.Comment: 4 pages, 2 figures, Proceedings of the 22nd International Spin
Symposium, Urbana-Champaign, Illinois, USA, 25-30 September 201
Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach
Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in â„ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered
Avoided Critical Behavior in O(n) Systems
Long-range frustrating interactions, even if their strength is infinitesimal,
can give rise to a dramatic proliferations of ground or near-ground states. As
a consequence, the ordering temperature can exhibit a discontinuous drop as a
function of the frustration. A simple model of the doped Mott insulator, where
the short-range tendency of the holes to phase separate competes with
long-range Coulomb effects, exhibits this "avoided critical" behavior. This
model may serve as a paradigm for many other systems.Comment: 4 pages, 2 figure
RATAN-600 7.6-cm Deep Sky Strip Surveys at the Declination of the SS433 Source During the 1980-1999 Period. Data Reduction and the Catalog of Radio Sources in the Right-Ascension Interval 7h < R.A. < 17h
We use two independent methods to reduce the data of the surveys made with
RATAN-600 radio telescope at 7.6 cm in 1988-1999 at the declination of the
SS433 source. We also reprocess the data of the "Cold" survey (1980-1981). The
resulting RCR (RATAN COLD REFINED) catalog contains the right ascensions and
fluxes of objects identified with those of the NVSS catalog in the
right-ascension interval 7h < R.A. < 17h. We obtain the spectra of the radio
sources and determine their spectral indices at 3.94 and 0.5 GHz. The spectra
are based on the data from all known catalogs available from the CATS, Vizier,
and NED databases, and the flux estimates inferred from the maps of the VLSS
and GB6 surveys. For 245 of the 550 objects of the RCR catalog the fluxes are
known at two frequencies only: 3.94 GHz (RCR) and 1.4 GHz (NVSS). These are
mostly sources with fluxes smaller than 30 mJy. About 65% of these sources have
flat or inverse spectra (alpha > -0.5). We analyze the reliability of the
results obtained for the entire list of objects and construct the histograms of
the spectral indices and fluxes of the sources. Our main conclusion is that all
10-15 mJy objects found in the considered right-ascension interval were already
included in the decimeter-wave catalogs.Comment: 26 pages, 18 figure
Flipping social determinants on its head: Medical student perspectives on the flipped classroom and simulated patients to teach social determinants of health
Background: Inequalities in healthcare are increasing. Engaging medical students to tackle this urgent challenge alongside clinical sciences can be demanding. This study examines medical student perceptions of a flipped approach to health inequalities co-designed by faculty and sixth-year students.
Innovation: A flipped learning session was piloted for year 4 medical students combining an online lesson followed by a tutorial with a simulated patient.
Methods: A mixed-methods approach collected questionnaire data using 4-point Likert scales and free text answers. A semi-structured group interview was conducted with six voluntary participants.
Results: Two hundred and eighty-nine students completed questionnaires. 85% (nâ=â246) completed the online lesson. Students agreed the session helped their understanding of key concepts (mean 3.2), was improved by having an actor (meanâ=â3.6), and was enjoyable (meanâ=â3.2). Thematic analysis of qualitative questionnaire and interview data revealed three themes: engagement; structure; and attitudes towards social determinants of health. The simulation increased clinical relevance and students gained understanding of the impact of health inequalities upon individuals.
Conclusions: This paper indicates flipped learning can increase clinical relevance and engagement in population health and person-centered care. Further work could assess changes in practice and attitudes of future doctors in tackling such global health challenges
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