Recurrent thromboembolism in pregnancy and puerperium. Is there a need for thromboprophylaxis?

By sending a questionnaire (response rate 93%) to 321 women with a history of venous thromboembolism and previous coagulation tests, 72 patients were identified who had a total of 87 pregnancies after the thromboembolic episode. The main aim of the study was to analyze the influence of prophylaxis during pregnancy and delivery on the development of further thromboembolic complications. During pregnancy there was no difference in frequency of thromboses between the group given prophylaxis (n = 20) and the group not receiving it (n = 67). At delivery the frequency of thrombosis was 5.3% among the 57 women given prophylaxis and 11.1% among the 30 without prophylaxis, a difference that is not significant. The implication of these findings is discussed both concerning the indications for giving prophylaxis and concerning the problem of designing relevant prophylactic trials

Paleofauna cretácica do centro de pesquisas paleontológicas Llewellyn Ivor Price,Peirópolis,Uberaba,MG

The Paleontological Site of Peirópolis, in the Bauru Group, Bauru Basin, is one of the best fossiliferous site of continental Upper Cretaceous in Brazil. It is located at the Triângulo Mineiro regin, 20Km east of the headquarters of the municipality of Uberaba, Minas Gerais state. In Peirópolis neighborhoods there are expositions of sedimentary rocks of Marília (Ponte Alta and Serra da Galga members) and Uberaba formations of the Bauru Group, where have been recorded fossils of invertebrates and vertebrates. Llewellyn Ivor Price was the first to carry out field trips and study the fossils of Peirópolis between 1947 and 1974. In 1992, the Centro de Pesquisas Paleontológicas Llewellyn Ivon Price (CPPLIP) and Museu dos Dinossauros were created, with two main goals: to house the fossils collected in Peirópolis and offer support to paleontological and geological research undertaken in the area. The Paleontological Site of Perirópolis is characterized by three fossiliferous localities named as "Point 1, 2 and 3" - where well-preserved fossils were collected. Large quantity of this cretaceous paleofauna is haused at the CPPLIP, reaching

Primata, roedores e litopternas do mio/plioceno da amazõnia sul-ocidental (formação solimões, bacia do acre), brasil

O material estudado pertence ao acervo do Laboratório de Paleontologia da Universidade Federal do Acre. Foi coletado nas localidades Patos (Alto Rio Acre, fronteira Brasil-Peru) e Talismã (Rio Purús, estado do Amazonas). Os sedimentos destas localidades são atribuidos a Formação Solimões, de idade Mioceno superior-Plioceno (Huayqueriense Montehermosense) Todos os espécimes de Patos pertencem a Litopterna-Proterotheriidae. Os fragmentos dentarios divergem dos litoptemas do Montehermosense e dos de La Venta, mas assemelham-se aos do "Mesopotamiense" e Santacruzense na morfologia, tamanho e gracilidade. Dois calcâneos foram atribuídos a proteroterídeos pelo prolongamento distal da faceta sustentacular e presença de faceta para o navicular. Os astrágalos atribuidos a roedores apresentam face medial espessa; tróclea prolongando sobre o colo e Iimitada distalmente por uma crista; faceta ectal suavemente cóncava e sustentacular plana a ligeiramente convexa, sem concavidade no terço proximal. O espécime com tamanho Intermediário entre Agouti eDasyprocta, pela similaridade ao primeiro táxon, foi atribuído a familia Agoutidae. Um outro astrágalo, com tamanho equivalente ao de Hydrochoerus, é distinto do astrágalo dos roedores recentes pelo colo muito longo. Pela freqüencia de dentes de Neoepiblemidae no afloramento onde aquele foi coletado, e pelo grande tamanho de alguns de seus membros, o espécime foi tentativamente classificado nesta familia. Um astrágalo apresenta tróclea mais larga distalmente, e faceta maleolar medial cóncava e naporção distal da tróclea/proximal do colo, características típicas de primatas. Pela tróclea de contorno mais plana e com concavidade média mais acentuada, e pela semelhança com o de Ateles, este espécime foi atribuído a familia Atelidae.The specimens studied belong to the fossil collection of the Federal University of Acre, Brazil. They were collected in two sites of Solimões Formation: Patos (Acre river, at the border between Peru and Brazil) and Talismã (Purús river, State of Amazonas), both of late Miocene/Pliocene in age (Huayquerian-Montehermosan).  The dental remains of Patos site are similar to the Litopterna-Proterotheriidae of 'Mesopotamian" and Santacrucian. The calcanea were assigned to proterotheres based on the anterodorsal articular extension of the sustentacular facet and the presence of a navicular facet. The astragali with a deep medial face, trochlea extending onto the neck and distally bordered by a crest and sustentacular facet flat to convex, but lacking a concavity on the proximal third. The sum of these characters suggests a rodent affinity. The specimen of intermediate size between Agouti and Dasyprocta is more similar to the first. and thus is assigned to Agoutidae. The other astragalus is of appropriate size for Hydrochoerus, but differs from all extant rodents in its longer neck. Teeth of rodents of the family Neoepiblemidae are very common in the outcrop where the astragalus was collect and, since members of this family reached very large sizes, the specimen was tentatively assigned to the Neoepiblemidae. Another astragalus bears a trochlea larger distally than proximally and concave medial malleolar facet, placed at the distal end of the trochlea/ proxymal end of the neck; these are diagnostic features of primates. The flat outline of the trochlea with a deep medium concavity, and the similarity with Ateles, support the assiqnment of this specimen to the family Atelidae.El material estudiado fue colectado en las localidades Palos (Alto Rio Acre, frontera Brasil-Perú) y Taliamã (Rio Purús, Amazonas). Los sedimentos han sido atribuidos a la Formación Solimões, de edad Mioceno tardío-Plioceno (Huayqueriense-Montehermosense). Los fragmentos dentarios pertenecientes a los Litopterna-Proterotheriidae son similares a los del "Mesopotamiense" y Santacrucense en la morfología, tamaño y gracilidad, mientras que los calcáneos presentan la prolongación distal de la faceta sustentacular y presencia de faceta para el navicular, característicos de los proterotéridos. Astrágalos con la cara medial espesa, tróclea prolongada sobre el cuello y limitada distalmente por una crista; faceta ectal suavemente cóncava y sustentacular plana a Iigeramente convexa, sin concavidad en el tercio proximal son atribuidos a roedores. El espécimen de tamaño intermedioentre Agouti y Dasuprocta es atribuido a la familia Agoutidae por la mayor similitud con el primer taxon. El restante astrágalo tiene tamaño equivalente al de Hydrochoerus, pero con el cuello muy largo. Por la frecuencia de dientes de Neoepiblemidae en la localidad fosilífera, y por el gran tamaño de algunos de sus representantes, el espécimen es tentativamente atribuido a esta familia. Un tercer astrágalo presenta la tróclea más ancha distalmente y faceta maleolar medial cóncava en la porción distal de la tróclea/proximal del cuello, características típicas de primates. Por la tróclea de contorno más plano y con concavidad media más acentuada, y por la similitud con los astrágalos de Ateles, el espécimen es atribuido a la familia Atelidae

Phylogenetic relationships and palaeobiology of a new xenungulate (Mammalia: Eutheria) from the Palaeogene of Argentina

Xenungulates are a peculiar group of bilophodont ungulates, widespread over South America during the Paleocene and early Eocene. Here we describe, illustrate and analyse a new Xenungulata, Rodcania kakan gen. et sp. nov., the first from the lower latitudes of Argentina. It was recovered from the Río Loro Formation (Tucumán Province), for which a Paleocene age was estimated. The material comprises a fragment of the left dentary with an incomplete m2, eroded over the enamel surface, and an almost complete m3. Both teeth share with Xenungulata strong enamel, vertically oriented Hunter–Schreger bands (HSB), and wear facets sloping distally. Rodcania kakan differs from other xenungulates in the m3 trigonid, simplified and mesiodistally short; absence of a paraconid; more oblique protolophid in relation to the mesiodistal axis and a straight cristid obliqua, pointing to the protoconid position; and has a wider and longer talonid. A phylogenetic analysis of 13 species and 36 craniodental characters recovered R. kakan as a basal member of the Carodniidae, supported by 10 synapomorphies in the four most parsimonious trees. The body mass estimation of the Río Loro Fauna and of the rest of the xenungulate taxa revealed that R. kakan is the largest mammal of the Río Loro assemblage, weighing around 165 kg and with a size comparable to Carodnia feruglioi. The increase in body mass showed no clear relation with evolutionary trends in xenungulates.Fil: Gelfo, Javier Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Paleontología de Vertebrados; ArgentinaFil: Garcia Lopez, Daniel Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Bergqvist, Lilian P.. Universidade Federal do Rio de Janeiro; Brasi

Figure 10 in Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia)

Figure 10. Strict consensus cladogram (518 steps, consistency index = 0.36, retention index = 0.71) of the analysis with 50 taxa searching for the relationships of the UFRJ-DG petrosals under study.Published as part of <i>Billet, Guillaume, Muizon, Christian De, Schellhorn, Rico, Ruf, Irina, Ladevèze, Sandrine & Bergqvist, Lilian, 2015, Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia), pp. 956-987 in Zoological Journal of the Linnean Society 173 (4)</i> on page 973, DOI: 10.1111/zoj.12219, <a href="http://zenodo.org/record/10106367">http://zenodo.org/record/10106367</a&gt

The intertropical Brazilian species of Panochthus (Xenarthra, Cingulata, Glyptodontoidea): a reappraisal of their taxonomy and phylogenetic affinities

Four species of Panochthus (P. greslebini, P. jaguaribensis, P. oliveira-roxoi, and P. rochai) have been described from the late Pleistocene of northeastern Brazil. P. oliveira-roxoi, and P. rochai have been considered loosely as synonyms of P. greslebini. This paper reevaluates the referred material, diagnostic characters, and validity of these species and includes a cladistic analysis of 25 caudal tube and carapace characters to determine their positioning relative to other species of Panochthus. P. greslebini and P. jaguaribensis are valid species and differ from the other species of Panochthus by unique combinations of caudal tube characters. Carapace fragments previously attributed to P. jaguaribensis are in fact fragments of cephalic shields. These fragments and the isolated ostoderms previously described for P. jaguaribensis cannot be confidently assigned to this species. We support the interpretation of P. rochai as a junior synonym of P. greslebini, but P. oliveira-roxoi is actually a nomen dubium instead of a synonym of P. greslebini. Our analysis yielded a fully resolved tree in which Panochthini, as traditionally defined, is paraphyletic and the species formerly attributed to Panochthus form a monophyletic group, echoing recent findings based on a different dataset. Within Panochthus, the Brazilian species form a clade with the Bonaerian species P. subintermedius, which is the sister species to P. greslebini. Instead of a more basal position suggested in early and recent works, P. jaguaribensis is deeply nested within the clade encompassing the species of Panochthus.Fil: Porpino, Kleberson de O.. Universidade Federal do Rio Grande do Norte; BrasilFil: Fernicola, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaFil: Cruz, Laura Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Bergqvist, Lilian P.. Universidade Federal do Rio de Janeiro; Brasi

Figure 5. Virtual 3D in Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia)

Figure 5. Virtual 3D reconstruction and outline drawing of petrosal UFRJ-DG 1036-M (mirrored), details of anatomy; A, cerebellar view; B, dorsal view. Abbreviations: aav, external aperture of the vestibular aqueduct; acan n, notch housing the external aperture of the cochlear canaliculus; cev s?, sulcus for capsuloparietal emissary vein?; circ. fs, (vascular?) circular fossa; cn, canal and cribriform tract for cochlear nerve; cp (br.), crista petrosa (broken); cpa, crista parotica; exs, exoccipital articulation surface of petrosal; fai, foramen acusticum inferius; fas, foramen acusticum superius; ff, facial foramen; fi, fossa incudis; fsa, fossa subarcuata; fsg, foramen singulare; f sup vest, foramen for the superior vestibule area; ips, sulcus of inferior petrosal sinus; lv.ips, crest-like lateroventral border of sulcus for inferior petrosal sinus; md.ips, crest-like mediodorsal border of sulcus for inferior petrosal sinus; obl.g, oblique groove; pg, posterior occipital groove; pmc, petromastoid canal; pr, promontorium; ptn, post-temporal notch; pts, post-temporal sulcus; sps, sulcus of superior petrosal sinus; sqs, squamosal articulation surface of petrosal; st.s., stapedial artery sulcus; tt, tegmen tympani.Published as part of <i>Billet, Guillaume, Muizon, Christian De, Schellhorn, Rico, Ruf, Irina, Ladevèze, Sandrine & Bergqvist, Lilian, 2015, Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia), pp. 956-987 in Zoological Journal of the Linnean Society 173 (4)</i> on page 965, DOI: 10.1111/zoj.12219, <a href="http://zenodo.org/record/10106367">http://zenodo.org/record/10106367</a&gt

Figure 15 in Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia)

Figure 15. Strict consensus cladogram (528 steps, consistency index = 0.347, retention index = 0.692) of the constrained 49 taxa analysis, with UFRJ-DG 119-M, 275-M, 347-M, and 1035−1038-M petrosals as pertaining to Miguelsoria; Litopterna constrained for monophyly.Published as part of <i>Billet, Guillaume, Muizon, Christian De, Schellhorn, Rico, Ruf, Irina, Ladevèze, Sandrine & Bergqvist, Lilian, 2015, Petrosal and inner ear anatomy and allometry amongst specimens referred to Litopterna (Placentalia), pp. 956-987 in Zoological Journal of the Linnean Society 173 (4)</i> on page 977, DOI: 10.1111/zoj.12219, <a href="http://zenodo.org/record/10106367">http://zenodo.org/record/10106367</a&gt