An automated system for spacecraft proximity operations

With the advent of multiple-vehicle operations in support of the space station, on-orbit refurbishment, and several other missions, there is a need to intelligently plan proximity operations trajectories that will conserve limited available fuel while avoiding collisions. Upon reaching the objective, the capture process entails several unique considerations, such as coordinating motion with a tumbling target, the capture itself, and adapting to control of the new configuration resulting from the capture operation. This paper outlines a systematic process of technical development over several years at the Draper laboratory, culminating in a capability to perform manual augmented or fully autonomous rendezvous, capture, and control of the resulting configuration

Population synthesis of HII galaxies

We study the stellar population of galaxies with active star formation, determining ages of the stellar components by means of spectral population synthesis of their absorption spectra. The data consist of optical spectra of 185 nearby ($z \leq 0.075$) emission line galaxies. They are mostly HII galaxies, but we also include some Starbursts and Seyfert 2s, for comparison purposes. They were grouped into 19 high signal-to-noise ratio template spectra, according to their continuum distribution, absorption and emission line characteristics. The templates were then synthesized with a star cluster spectral base. The synthesis results indicate that HII galaxies are typically age-composite stellar systems, presenting important contribution from generations up to as old as 500 Myr. We detect a significant contribution of populations with ages older than 1 Gyr in two groups of HII galaxies. The age distributions of stellar populations among Starbursts can vary considerably despite similarities in the emission line spectra. In the case of Seyfert 2 groups we obtain important contributions of old population, consistent with a bulge. From the diversity of star formation histories, we conclude that typical HII galaxies in the local universe are not systems presently forming their first stellar generation.Comment: 12 pages, 4 figures, MNRAS in pres

Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas

BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the fibroblast growth factor receptors (FGFR)-family. Single-nucleotide polymorphism (SNP) Arg388 of the FGFR4 is associated with a reduced overall survival in patients with cancers of various types. We speculate that FGFR4 expression and SNP is associated with worse survival in patients with HSNCC. AIM To investigate the potential clinical significance of FGFR4 Arg388 in the context of tumors arising in HNSCC, a comprehensive analysis of FGFR4 receptor expression and genotype in tumor tissues and correlated results with patients' clinical data in a large cohort of patients with HNSCC was conducted. METHODS Surgical specimens from 284 patients with HNSCC were retrieved from the Institute of Pathology at the Ludwig-Maximilian-University in Germany. Specimens were analyzed using immunohistochemistry and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The expression of FGFR4 was analyzed in 284 surgical specimens of HNSCC using immunohistochemstry. FGFR4 polymorphism was detected by PCR-RFLP. Patients' clinical data with a minimum follow-up of 5 syears were statistically evaluated with a special emphasis on survival analysis employing Kaplan-Meier estimator and Cox regression analysis. RESULTS Concerning the invasive tumor areas the intensity of the FGFR4 expression was evaluated in a four-grade system: no expression, low expression, intermediate and high expression. FGFR4 expression was scored as "high" (+++) in 74 (26%), "intermediate" (++) in 103 (36.3%), and "low" (+) in 107 (36.7%) cases. Analyzing the FGFR4 mutation it was found in 96 tumors (33.8%), 84 of them (29.6%) having a heterozygous and 12 (4.2%) homozygous mutated Arg388 allele. The overall frequency concerning the mutant alleles demonstrated 65% vs 34% mutated alleles in general. FGFR4 Arg388 was significantly associated with advanced tumor stage (P < 0.004), local metastasis (P < 0.0001) and reduced disease-free survival (P < 0.01). Furthermore, increased expression of FGFR4 correlated significantly with worse overall survival (P < 0.003). CONCLUSION In conclusion, the FGFR4 Arg388 genotype and protein expression of FGFR4 impacts tumor progression in patients with HNSCC and may present a useful target within a multimodal therapeutic intervention

The Nature of the Optical Light in Seyfert 2 Galaxies with Polarized Continuum

We investigate the nature of the optical continuum and stellar population in the central kpc of the Seyfert 2s Mrk 348, Mrk 573, NGC 1358 and Mrk 1210 using long-slit spectra obtained along the radio or extended emission axis. These galaxies are known to have polarized continuum-including polarized broad lines in Mrk 348 and Mrk 1210--and previous studies indicate featureless continuum (FC) contributions in the 20-50% range at 5500 A. Nevertheless, our measurements of the equivalent widths of absorption lines and continuum ratios as a function of distance from the nuclei show no dilution of the lines nor bluening of the spectrum, as expected if a blue FC was present at the nucleus in the above proportions. We investigate one possibility to account for this effect: that the stellar population at the nucleus is the same as that from the surrounding bulge and dominates the nuclear light. A spectral analysis confirms that this hypothesis works for Mrk 348, NGC 1358 and Mrk 1210, for which we find stellar contributions at the nucleus larger than 90% at all wavelengths. We find that a larger stellar population contribution to the nuclear spectra can play the role of the ``second FC'' source inferred from previous studies. Stellar population synthesis shows that the nuclear regions of Mrk 348 and Mrk 1210 have important contributions of young to intermediate age stars (0--100 Myr), not present in templates of elliptical galaxies. In the case of Mrk 1210, this is further confirmed by the detection of a ``Wolf-Rayet feature'' in the nuclear emission-line spectrum.Comment: ApJ, accepted. Uses aaspp4.sty. [22 pages

Mechanical characterization of disordered and anisotropic cellular monolayers

We consider a cellular monolayer, described using a vertex-based model, for which cells form a spatially disordered array of convex polygons that tile the plane. Equilibrium cell configurations are assumed to minimize a global energy defined in terms of cell areas and perimeters; energy is dissipated via dynamic area and length changes, as well as cell neighbour exchanges. The model captures our observations of an epithelium from a Xenopus embryo showing that uniaxial stretching induces spatial ordering, with cells under net tension (compression) tending to align with (against) the direction of stretch, but with the stress remaining heterogeneous at the single-cell level. We use the vertex model to derive the linearized relation between tissue-level stress, strain and strain-rate about a deformed base state, which can be used to characterize the tissue's anisotropic mechanical properties; expressions for viscoelastic tissue moduli are given as direct sums over cells. When the base state is isotropic, the model predicts that tissue properties can be tuned to a regime with high elastic shear resistance but low resistance to area changes, or vice versa.Comment: 9 figure

Effects of new physics in neutrino oscillations in matter

A new flavor changing electron neutrino interaction with matter would always dominate the nu_e oscillation probability at sufficiently high neutrino energies. Being suppressed by theta_{13}, the energy scale at which the new effect starts to be relevant may be within the reach of realistic experiments, where the peculiar dependence of the signal with energy could give rise to a clear signature in the nu_e --> nu_tau channel. The latter could be observed by means of a coarse large magnetized detector by exploiting tau --> mu decays. We discuss the possibility of identifying or constraining such effects with a high energy neutrino factory. We also comment on the model independent limits on them.Comment: 11 pages, 5 figure

Signals of R-parity violating supersymmetry in neutrino scattering at muon storage rings

Neutrino oscillation signals at muon storage rings can be faked by supersymmetric (SUSY) interactions in an R-parity violating scenario. We investigate the $\tau$-appearance signals for both long-baseline and near-site experiments, and conclude that the latter is of great use in distinguishing between oscillation and SUSY effects. On the other hand, SUSY can cause a manifold increase in the event rate for wrong-sign muons at a long-baseline setting, thereby providing us with signatures of new physics.Comment: 7 pages LaTeX, 4 ps figures, accepted for publication in Phys. Rev.