Simulation Methods for the Transient Analysis of Synchronous Alternators

The integration of unconventional renewable energy sources on the electrical grid poses challenges to the electrical engineer. This chapter focuses on the transient modeling of electrical machines. These models can be used for the design of generator control, the definition of the protection strategies, stability studies, and the evaluation of the electrical; mechanical; and thermal constraints on the machine. This chapter presents three modeling techniques: the standard d-q equivalent model, the coupled-circuit model, and the finite element model (FEM). The consideration of magnetic saturation for the different models is presented. The responses of the different models during three-phase, two-phase, and one-phase sudden short circuit are compared

Lax operator for Macdonald symmetric functions

Using the Lax operator formalism, we construct a family of pairwise commuting operators such that the Macdonald symmetric functions of infinitely many variables and of two parameters q, t are their eigenfunctions. We express our operators in terms of the Hall-Littlewood symmetric functions of the variables and of the parameter t corresponding to the partitions with one part only. Our expression is based on the notion of Baker-Akhiezer function

A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C

BACKGROUND: Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis. As a result it is considered a major target for intervention of these diseases. METHODOLOGY/PRINCIPAL FINDINGS: Herein, we report, for the first time, the synthesis and biological evaluation of a newly designed potent furin inhibitor that contains a highly reactive beta-turn inducing and radical generating "enediynyl amino acid" (Eda) moiety. "Eda" was inserted between P1 and P1' residues of hfurin(98-112) peptide, derived from the primary cleavage site of furin's own prodomain. The resulting hexadecapeptide derivative inhibited furin in vitro with IC(50) approximately 40 nM when measured against the fluorogenic substrate Boc-RVRR-MCA. It also inhibited furin-mediated cleavage of a fluorogenic peptide derived from hSARS-CoV spike protein with IC(50) approximately 193 nM. Additionally it also blocked furin-processing of growth factors proPDGF-A, B and VEGF-C that are linked to tumor genesis and cancer. Circular dichroism study showed that this inhibitor displayed a predominantly beta-turn structure while western blots confirmed its ability to protect furin protein from self degradation. CONCLUSION/SIGNIFICANCE: These findings imply its potential as a therapeutic agent for intervention of cancer and other furin-associated diseases

Étude du double pas de calcul pour la simulation numérique des réseaux électriques

Ce mémoire présente une étude sur la simulation en temps réel des réseaux électriques comportant des convertisseurs électronique de puissance, en utilisant deux pas de calcul différents. L'impact du double pas de calcul sur la précision de la simulation est d'abord étudié à l'aide de SimPowerSystems (MATLAB) puis validé en temps différé avec Hypersim, le logiciel de simulation temps réel d'Hydro-Québec. L'impact est étudié par l'observation des formes d'onde, par l'analyse harmonique, ainsi que par les mesures de puissance au point de découplage, entre les deux parties du réseau. La méthode de simulation à double pas de calcul pourrait être implantée, en temps réel, par l'utilisation d'une unité de calcul rapide dans Hypersim. La technologie FPGA « Field Programmable Gate Array » est considérée pour remplir cette fonction et ses caractéristiques sont passées en revue

Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission

For adults with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in first complete remission (CR1), allogeneic hematopoietic cell transplantation (HCT) is an established curative strategy. However, pediatric-inspired chemotherapy may also offer durable leukemia-free survival in the absence of HCT. We compared 422 HCT recipients aged 18-50 years with Ph-ALL in CR1 reported to the CIBMTR with an age-matched concurrent cohort of 108 Ph- ALL CR1 patients who received a Dana-Farber Consortium pediatric-inspired non-HCT regimen. At 4 years of follow-up, incidence of relapse after HCT was 24% (95% CI 19-28) versus 23% (95% CI 15-32) for the non-HCT (chemo) cohort (P=0.97). Treatment-related mortality (TRM) was higher in the HCT cohort [HCT 37% (95% CI 31-42) versus chemo 6% (95% CI 3-12), P<0.0001]. DFS in the HCT cohort was 40% (95% CI 35-45) versus 71% (95% CI 60-79) for chemo, P<0.0001. Similarly, OS favored chemo [HCT 45% (95% CI 40-50)] versus chemo 73% [(95% CI 63-81), P<0.0001]. In multivariable analysis, the sole factor predictive of shorter OS was the administration of HCT [hazard ratio 3.12 (1.99-4.90), P<0.0001]. For younger adults with Ph- ALL, pediatric-inspired chemotherapy had lower TRM, no increase in relapse, and superior overall survival compared to HCT