162 research outputs found
The inverted XY universality of the superconductivity phase transition
It has been conjectured that the phase transition in the Ginzburg-Landau
theory is dual to the XY model transition. We study numerically a particular
limit of the GL theory where this duality becomes exact, clarifying some of the
problems encountered in standard GL theory simulations. This may also explain
the failure of the superconductor experiments to observe the XY model scaling.Comment: Lattice2002(higgssusy), 3 page
The Thermal Renormalization Group for Fermions, Universality, and the Chiral Phase-Transition
We formulate the thermal renormalization group, an implementation of the
Wilsonian RG in the real-time (CTP) formulation of finite temperature field
theory, for fermionic fields. Using a model with scalar and fermionic degrees
of freedom which should describe the two-flavor chiral phase-transition, we
discuss the mechanism behind fermion decoupling and universality at second
order transitions. It turns out that an effective mass-like term in the fermion
propagator which is due to thermal fluctuations and does not break chiral
symmetry is necessary for fermion decoupling to work. This situation is in
contrast to the high-temperature limit, where the dominance of scalar over
fermionic degrees of freedom is due to the different behavior of the
distribution functions. The mass-like contribution is the leading thermal
effect in the fermionic sector and is missed if a derivative expansion of the
fermionic propagator is performed. We also discuss results on the
phase-transition of the model considered where we find good agreement with
results from other methods.Comment: References added, minor typos correcte
Critical behaviour of the Ginzburg-Landau model in the type II region
We study the critical behaviour of the three-dimensional U(1) gauge+Higgs
theory (Ginzburg-Landau model) at large scalar self-coupling \lambda (``type II
region'') by measuring various correlation lengths as well as the
Abrikosov-Nielsen-Olesen vortex tension. We identify different scaling regions
as the transition is approached from below, and carry out detailed comparisons
with the criticality of the 3d O(2) symmetric scalar theory.Comment: Lattice2001(higgssusy), 3 page
Heisenberg frustrated magnets: a nonperturbative approach
Frustrated magnets are a notorious example where the usual perturbative
methods are in conflict. Using a nonperturbative Wilson-like approach, we get a
coherent picture of the physics of Heisenberg frustrated magnets everywhere
between and . We recover all known perturbative results in a single
framework and find the transition to be weakly first order in . We compute
effective exponents in good agreement with numerical and experimental data.Comment: 5 pages, Revtex, technical details available at
http://www.lpthe.jussieu.fr/~tissie
TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors
Despite the promising efficacy of adoptive cell therapies (ACT) in melanoma, complete response rates remain relatively low and outcomes in other cancers are less impressive. The immunosuppressive nature of the tumor microenvironment and the expression of immune-inhibitory ligands, such as PD-L1/CD274 by the tumor and stroma are considered key factors limiting efficacy. The addition of checkpoint inhibitors (CPI) to ACT protocols bypasses some mechanisms of immunosuppression, but associated toxicities remain a significant concern. To overcome PD-L1–mediated immunosuppression and reduce CPI-associated toxicities, we used TALEN technology to render tumor-reactive T cells resistant to PD-1 signaling. Here, we demonstrate that inactivation of the PD-1 gene in melanoma-reactive CD8+ T cells and in fibrosarcoma-reactive polyclonal T cells enhanced the persistence of PD-1 gene-modified T cells at the tumor site and increased tumor control. These results illustrate the feasibility and potency of approaches incorporating advanced gene-editing technologies into ACT protocols to silence immune checkpoints as a strategy to overcome locally active immune escape pathways
Numerical study of duality and universality in a frozen superconductor
The three-dimensional integer-valued lattice gauge theory, which is also
known as a "frozen superconductor," can be obtained as a certain limit of the
Ginzburg-Landau theory of superconductivity, and is believed to be in the same
universality class. It is also exactly dual to the three-dimensional XY model.
We use this duality to demonstrate the practicality of recently developed
methods for studying topological defects, and investigate the critical behavior
of the phase transition using numerical Monte Carlo simulations of both
theories. On the gauge theory side, we concentrate on the vortex tension and
the penetration depth, which map onto the correlation lengths of the order
parameter and the Noether current in the XY model, respectively. We show how
these quantities behave near the critical point, and that the penetration depth
exhibits critical scaling only very close to the transition point. This may
explain the failure of superconductor experiments to see the inverted XY model
scaling.Comment: 17 pages, 18 figures. Updated to match the version published in PRB
(http://link.aps.org/abstract/PRB/v67/e014525) on 27 Jan 200
Structural Material Property Tailoring Using Deep Neural Networks
Advances in robotics, artificial intelligence, and machine learning are
ushering in a new age of automation, as machines match or outperform human
performance. Machine intelligence can enable businesses to improve performance
by reducing errors, improving sensitivity, quality and speed, and in some cases
achieving outcomes that go beyond current resource capabilities. Relevant
applications include new product architecture design, rapid material
characterization, and life-cycle management tied with a digital strategy that
will enable efficient development of products from cradle to grave. In
addition, there are also challenges to overcome that must be addressed through
a major, sustained research effort that is based solidly on both inferential
and computational principles applied to design tailoring of functionally
optimized structures. Current applications of structural materials in the
aerospace industry demand the highest quality control of material
microstructure, especially for advanced rotational turbomachinery in aircraft
engines in order to have the best tailored material property. In this paper,
deep convolutional neural networks were developed to accurately predict
processing-structure-property relations from materials microstructures images,
surpassing current best practices and modeling efforts. The models
automatically learn critical features, without the need for manual
specification and/or subjective and expensive image analysis. Further, in
combination with generative deep learning models, a framework is proposed to
enable rapid material design space exploration and property identification and
optimization. The implementation must take account of real-time decision cycles
and the trade-offs between speed and accuracy
Masses and Phase Structure in the Ginzburg-Landau Model
We study numerically the phase structure of the Ginzburg-Landau model, with
particular emphasis on mass measurements. There is no local gauge invariant
order parameter, but we find that there is a phase transition characterized by
a vanishing photon mass. For type I superconductors the transition is of 1st
order. For type II 1st order is excluded by susceptibility analysis, but the
photon correlation length suggests 2nd order critical behaviour with \nu ~ 1/2.
The scalar mass, in contrast, does not show clear critical behaviour in the
type II regime for V \to \infty, contrary to the conventional picture.Comment: 16 pages, 6 figures. More data gathered, allowing more definite
conclusion
Thermodynamics of Gauge-Invariant U(1) Vortices from Lattice Monte Carlo Simulations
We study non-perturbatively and from first principles the thermodynamics of
vortices in 3d U(1) gauge+Higgs theory, or the Ginzburg-Landau model, which has
frequently been used as a model for cosmological topological defect formation.
We discretize the system and introduce a gauge-invariant definition of a vortex
passing through a loop on the lattice. We then study with Monte Carlo
simulations the total vortex density, extract the physically meaningful part
thereof, and demonstrate that it has a well-defined continuum limit. The total
vortex density behaves as a pseudo order parameter, having a discontinuity in
the regime of first order transitions and behaving continuously in the regime
of second order transitions. Finally, we discuss further gauge-invariant
observables to be measured.Comment: 13 pages, 5 figures. Some references added; to appear in Phys.Lett.
Critical Phenomena with Linked Cluster Expansions in a Finite Volume
Linked cluster expansions are generalized from an infinite to a finite
volume. They are performed to 20th order in the expansion parameter to approach
the critical region from the symmetric phase. A new criterion is proposed to
distinguish 1st from 2nd order transitions within a finite size scaling
analysis. The criterion applies also to other methods for investigating the
phase structure such as Monte Carlo simulations. Our computational tools are
illustrated at the example of scalar O(N) models with four and six-point
couplings for and in three dimensions. It is shown how to localize
the tricritical line in these models. We indicate some further applications of
our methods to the electroweak transition as well as to models for
superconductivity.Comment: 36 pages, latex2e, 7 eps figures included, uuencoded, gzipped and
tarred tex file hdth9607.te
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