5,975 research outputs found
Molecular diagnosis of multiple endocrine neoplasia type 2A
Objective. To identify by means of genetic analyses individuals who are at risk of developing medullary thyroid cancer that is a component of multiple endocrine neoplasia.Subjects. A three-generation kindred with clinically and biochemically diagnosed medUllary thyroid cancer.Method. Identification of a heterozygote mutation by nucleic acid sequencing and restriction analyses.Results. A heterozygote T â C (Cys â Arg) mutation at codon 618 in exon 10 of the RET proto-oncogene was identified in 4 family members who had previously been diagnosed with medullary thyroid cancer. The same mutation was also found in one of the proband's presymptomatic children who subsequently underwent a preemptive thyroidectomy. The genetic diagnosis was confirmed by histology. No mutations were detected in any other family members.Conclusion. Identification of heterozygote germline mutations in multiple endocrine neoplasia is direct, highly accurate and cost-effective. This study demonstrates that, appropriately used, molecular diagnosis can supersede conventional biochemical methods in the management of patients with inherited cancers
Moiré patterns observed in bi layer graphene irradiated with high energetic protons
Customarily, it is likely that irradiated graphene yield indication of per- turbations induced by irradiation. High Resolution Transmission Electron Micros- copy (HRTEM) analysis has been performed on proton irradiated graphene. The analysis indicates the existence of MoireÌ patterns produced by the rotations induced by the irradiation in between planes. The rotations measured fluctuate between 3 and 5 degrees respectively. These rotations may influence the electronic properties of the material under investigation. In order to explain the observed rotations in between planes, theoretical analysis were performed under the scheme of extended HuÌckel tight-binding method. Average total energy of the system was careful ana- lyzed throughout the experiment composed of two graphene layers with two carbon vacancies and then the replaced carbons were intercalated in between the two lay- ers. The results obtained indicate that the system remain semi metallic. Moreover, the theoretical results yielded that the 3 degree rotation is favored, although the 5 degree rotation is not discarded. Furthermore, energy bands as well as total and projected DOS were performed in order to provide more information about the electronic changes induced by the rotations applied to the system
Radio Emission from Ultra-Cool Dwarfs
The 2001 discovery of radio emission from ultra-cool dwarfs (UCDs), the very
low-mass stars and brown dwarfs with spectral types of ~M7 and later, revealed
that these objects can generate and dissipate powerful magnetic fields. Radio
observations provide unparalleled insight into UCD magnetism: detections extend
to brown dwarfs with temperatures <1000 K, where no other observational probes
are effective. The data reveal that UCDs can generate strong (kG) fields,
sometimes with a stable dipolar structure; that they can produce and retain
nonthermal plasmas with electron acceleration extending to MeV energies; and
that they can drive auroral current systems resulting in significant
atmospheric energy deposition and powerful, coherent radio bursts. Still to be
understood are the underlying dynamo processes, the precise means by which
particles are accelerated around these objects, the observed diversity of
magnetic phenomenologies, and how all of these factors change as the mass of
the central object approaches that of Jupiter. The answers to these questions
are doubly important because UCDs are both potential exoplanet hosts, as in the
TRAPPIST-1 system, and analogues of extrasolar giant planets themselves.Comment: 19 pages; submitted chapter to the Handbook of Exoplanets, eds. Hans
J. Deeg and Juan Antonio Belmonte (Springer-Verlag
Orientation and symmetries of Alexandrov spaces with applications in positive curvature
We develop two new tools for use in Alexandrov geometry: a theory of ramified
orientable double covers and a particularly useful version of the Slice Theorem
for actions of compact Lie groups. These tools are applied to the
classification of compact, positively curved Alexandrov spaces with maximal
symmetry rank.Comment: 34 pages. Simplified proofs throughout and a new proof of the Slice
Theorem, correcting omissions in the previous versio
Effect of gender difference on platelet reactivity
Background Previous studies have suggested that women do not accrue equal therapeutic benefit from antiplatelet medication as compared with men. The physiological mechanism and clinical implications behind this gender disparity have yet to be established. Methods On-treatment platelet reactivity was determined in 717 men and 234 women on dual antiplatelet therapy, undergoing elective coronary stent implantation. Platelet function testing was performed using arachidonic acid and adenosine diphosphate-induced light transmittance aggregometry (LTA) and the VerifyNow P2Y12 and Aspirin assays. Also the incidence of all-cause death, non-fatal acute myocardial infarction, stent thrombosis and ischaemic stroke was evaluated. Results Women had higher baseline platelet counts than men. Women exhibited a higher magnitude of on-aspirin platelet reactivity using LTA, but not using the VerifyNow Aspirin assay. The magnitude of on-clopidogrel platelet reactivity was significantly higher in women as compared with men with both tests used. The cut-off value to identify patients at risk as well as the incidence of clinical endpoints was similar between women and men (16/234[6.8%] vs. 62/717[8.6%], p=0.38). Conclusion Although the magnitude of platelet reactivity was higher in women, the absolute difference between genders was small and both the cut-off value to identify patients at risk and the incidence of the composite endpoint were similar between genders. Thus, it is unlikely that the difference in platelet reactivity accounts for a worse prognosis in women
Theory of current-driven motion of Skyrmions and spirals in helical magnets
We study theoretically the dynamics of the spin textures, i.e., Skyrmion
crystal (SkX) and spiral structure (SS), in two-dimensional helical magnets
under external current. By numerically solving the Landau-Lifshitz-Gilbert
equation, it is found that (i) the critical current density of the motion is
much lower for SkX compared with SS in agreement with the recent experiment,
(ii) there is no intrinsic pinning effect for SkX and the deformation of the
internal structure of Skyrmion reduces the pinning effect dramatically, (iii)
the Bragg intensity of SkX shows strong time-dependence as can be observed by
neutron scattering experiment.Comment: 4 pages, 3 figure
Bipolar supercurrent in graphene
Graphene -a recently discovered one-atom-thick layer of graphite- constitutes
a new model system in condensed matter physics, because it is the first
material in which charge carriers behave as massless chiral relativistic
particles. The anomalous quantization of the Hall conductance, which is now
understood theoretically, is one of the experimental signatures of the peculiar
transport properties of relativistic electrons in graphene. Other unusual
phenomena, like the finite conductivity of order 4e^2/h at the charge
neutrality (or Dirac) point, have come as a surprise and remain to be
explained. Here, we study the Josephson effect in graphene. Our experiments
rely on mesoscopic superconducting junctions consisting of a graphene layer
contacted by two closely spaced superconducting electrodes, where the charge
density can be controlled by means of a gate electrode. We observe a
supercurrent that, depending on the gate voltage, is carried by either
electrons in the conduction band or by holes in the valence band. More
importantly, we find that not only the normal state conductance of graphene is
finite, but also a finite supercurrent can flow at zero charge density. Our
observations shed light on the special role of time reversal symmetry in
graphene and constitute the first demonstration of phase coherent electronic
transport at the Dirac point.Comment: Under review, 12 pages, 4 Figs., suppl. info (v2 identical, resolved
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Chirped pulse Raman amplification in warm plasma: towards controlling saturation
Stimulated Raman backscattering in plasma is potentially an efficient method of amplifying laser pulses to reach exawatt powers because plasma is fully broken down and withstands extremely high electric fields. Plasma also has unique nonlinear optical properties that allow simultaneous compression of optical pulses to ultra-short durations. However, current measured efficiencies are limited to several percent. Here we investigate Raman amplification of short duration seed pulses with different chirp rates using a chirped pump pulse in a preformed plasma waveguide. We identify electron trapping and wavebreaking as the main saturation mechanisms, which lead to spectral broadening and gain saturation when the seed reaches several millijoules for durations of 10's - 100's fs for 250 ps, 800 nm chirped pump pulses. We show that this prevents access to the nonlinear regime and limits the efficiency, and interpret the experimental results using slowly-varying-amplitude, current-averaged particle-in-cell simulations. We also propose methods for achieving higher efficiencies.close0
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Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle
Rodent models of tinnitus are commonly used to study its mechanisms and potential treatments. Tinnitus can be identified by changes in the gap-induced prepulse inhibition of the acoustic startle (GPIAS), most commonly by using pressure detectors to measure the whole-body startle (WBS). Unfortunately, the WBS habituates quickly, the measuring system can introduce mechanical oscillations and the response shows considerable variability. We have instead used a motion tracking system to measure the localized motion of small reflective markers in response to an acoustic startle reflex in guinea pigs and mice. For guinea pigs, the pinna had the largest responses both in terms of displacement between pairs of markers and in terms of the speed of the reflex movement. Smaller, but still reliable responses were observed with markers on the thorax, abdomen and back. The peak speed of the pinna reflex was the most sensitive measure for calculating GPIAS in the guinea pig. Recording the pinna reflex in mice proved impractical due to removal of the markers during grooming. However, recordings from their back and tail allowed us to measure the peak speed and the twitch amplitude (area under curve) of reflex responses and both analysis methods showed robust GPIAS. When mice were administered high doses of sodium salicylate, which induces tinnitus in humans, there was a significant reduction in GPIAS, consistent with the presence of tinnitus. Thus, measurement of the peak speed or twitch amplitude of pinna, back and tail markers provides a reliable assessment of tinnitus in rodents
Extension of Some Edge Graph Problems: Standard and Parameterized Complexity
Le PDF est une version auteur non publiĂ©e.We consider extension variants of some edge optimization problems in graphs containing the classical Edge Cover, Matching, and Edge Dominating Set problems. Given a graph G=(V,E) and an edge set UâE, it is asked whether there exists an inclusion-wise minimal (resp., maximal) feasible solution EâČ which satisfies a given property, for instance, being an edge dominating set (resp., a matching) and containing the forced edge set U (resp., avoiding any edges from the forbidden edge set EâU). We present hardness results for these problems, for restricted instances such as bipartite or planar graphs. We counter-balance these negative results with parameterized complexity results. We also consider the price of extension, a natural optimization problem variant of extension problems, leading to some approximation results
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