7 research outputs found
Ăšj kĂ©rdĹ‘Ăv a szĂĽlĹ‘i egĂ©szsĂ©gműveltsĂ©g mĂ©rĂ©sĂ©re
Absztrakt
Bevezetés: Régóta ismert, hogy a szülők egészségügyi műveltsége
fontos tĂ©nyezĹ‘je a gyermekek egĂ©szsĂ©gĂ©nek. Világszerte sokfĂ©le megközelĂtĂ©sbĹ‘l
vizsgálták az egészségműveltséget, Magyarországon azonban eddig nem történt
kĂsĂ©rlet sem a definiálására, sem a mĂ©rĂ©sĂ©re. CĂ©lkitűzĂ©s: A
szerzők célja volt, hogy definiálják a szülői egészségműveltséget, és
lĂ©trehozzanak egy kĂ©rdĹ‘Ăvet, amelynek segĂtsĂ©gĂ©vel a szĂĽlĹ‘i egĂ©szsĂ©gműveltsĂ©g
pontosan felmérhető. Módszer: Szülők, védőnők és
gyermekgyĂłgyászok bevonásával állĂtották össze a szĂĽlĹ‘i egĂ©szsĂ©gműveltsĂ©g
témaköreit, és meghatározták, hogy ezeknek milyen dimenziói vannak. Ezek és a
szakirodalombĂłl ismert tesztek alapján állĂtották össze a felmĂ©rĂ©sĂ©re szolgálĂł
kĂ©rdĹ‘Ăvet. EredmĂ©nyek: A szĂĽlĹ‘i egĂ©szsĂ©gműveltsĂ©g nĂ©gyfĂ©le
dimenziója: az ismeretek, a funkcionális tudás, a magabiztosság és a motiváció.
A lĂ©trehozott kĂ©rdĹ‘Ăv a nĂ©gy dimenziĂłt nyolc tĂ©makörön keresztĂĽl vizsgálja.
Következtetések: Létrejött a szülői egészségműveltség első,
kulturálisan adaptált, magyar nyelvű definĂciĂłja Ă©s ennek mĂ©rĂ©sĂ©t segĂtĹ‘
kĂ©rdĹ‘Ăv. Alkalmazása segĂtsĂ©get nyĂşjthat mind az alapellátás, mind az
egészségnevelés hatékonyságának növelésében. Pontosan vizsgálhatóvá válhat a
szülők egészségügyi műveltségének és a gyermek egészségi állapotának kapcsolata.
Orv. Hetil., 2015, 156(42), 1715–1718
X-chromosome and kidney function:evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.</p
Exploring the dynamic changes of key concepts of the Hungarian socialist era with natural language processing methods
The analysis of social discourses from the perspective of historical changes deserves special attention. Such a study could play a key role in revealing social changes and latent narrative of those in power; and understanding the underlying social dynamic in a given period. Until the recent years, such issues were analyzed mainly in a qualitative approach. In our paper we present a new way of revealing/discovering and interpreting social discourses using an advanced NLP method called word embedding. Based on word similarities we can understand the main structural frames of a given system and using a dynamic approach we can reveal the social changes in a historical period. In our study we created a large corpus from the Hungarian “Pártélet” journal (1956–89). This was the official journal of the governing party, hence it represents not just a media discourse of the era, but the official discourse of the government, too. One of the main focal points of our research is to study the evolution of the semantic content of some of the concepts related to the topics of agriculture and industry, which are two central notions of the examined era
Exploring the dynamic changes of key concepts of the Hungarian socialist era with natural language processing methods
The analysis of social discourses from the perspective of historical changes deserves special attention. Such a study could play a key role in revealing social changes and latent narrative of those in power; and understanding the underlying social dynamic in a given period. Until the recent years, such issues were analyzed mainly in a qualitative approach. In our paper we present a new way of revealing/discovering and interpreting social discourses using an advanced NLP method called word embedding. Based on word similarities we can understand the main structural frames of a given system and using a dynamic approach we can reveal the social changes in a historical period. In our study we created a large corpus from the Hungarian “Pártélet” journal (1956–89). This was the official journal of the governing party, hence it represents not just a media discourse of the era, but the official discourse of the government, too. One of the main focal points of our research is to study the evolution of the semantic content of some of the concepts related to the topics of agriculture and industry, which are two central notions of the examined era
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X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research
Recommended from our members
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research