Strategies to Improve Patient Compliance Regarding Smoking Cessation

Exposure to cigarette smoke in the oral cavity alters the function of key periodontal pathogens such as P. gingivalis, promoting biofilm formation, colonization, and infection. The purpose of this review is to investigate how improved education on smoking can decrease negative oral health risks. Education amongst healthcare professionals and their patients is positively correlated to smoking cessation. Smoking counseling has been shown to be more effective when given by multiple healthcare professionals outside of and in addition to primary care. Evidence shows that the chances of breaking smoking habits increase as smoking cessation counseling, cost-free medications, and follow up visits increase. Quit rates amongst patients rise when both motivational interviewing and increased health education are implemented by healthcare providers. Literature indicates there is a need for improved collaboration between the medical and dental fields in order to improve oral health education for the general public. Research also shows that healthcare providers using multiple methods of smoking counseling in conjunction with one another have greater rates of success where decreased smoking rates are concerned.https://scholarscompass.vcu.edu/denh_student/1036/thumbnail.jp

Perceptions of employability among London's low-paid: 'self-determination' or ethnicity?

We investigate how ethnicity, gender and other characteristics affect low-paid workers’ perceptions of their employability in London’s labour market, examining ‘self-determination’, ethnic and dual labour market theories. We find that perceptions vary considerably, both between genders and ethnicities and in the extent to which they are ‘justified’ by human capital attributes. Optimism varies between genders and ethnic groups but individuals’ perceptions vary to an even greater extent within genders and ethnic groups. Hence, individual-level ‘self-determination’ explanations of these perceptions appear to have greatest explanatory power though ethnic theories also have utility

Translocator protein in late stage Alzheimer\u27s disease and Dementia with Lewy bodies brains

OBJECTIVE: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such as Alzheimer\u27s disease (AD) and Dementia with Lewy Bodies (DLB). In this study, we investigated the changes in TSPO density with respect to late stage AD and DLB. METHODS: TSPO density was measured in multiple regions of postmortem human brains in 20 different cases: seven late stage AD cases (Braak amyloid average: C; Braak tangle average: VI; Aged 74-88, mean: 83 ± 5 years), five DLB cases (Braak amyloid average: C; Braak tangle average: V; Aged 79-91, mean: 84 ± 4 years), and eight age-matched normal control cases (3 males, 5 females: aged 77-92 years; mean: 87 ± 6 years). Measurements were taken by quantitative autoradiography using [ RESULTS: No significant changes were found in TSPO density of the frontal cortex, striatum, thalamus, or red nucleus of the AD and DLB brains. A significant reduction in TSPO density was found in the substantia nigra (SN) of the AD and DLB brains compared to that of age-matched healthy controls. INTERPRETATION: This distinct pattern of TSPO density change in late stage AD and DLB cases may imply the occurrence of microglia dystrophy in late stage neurodegeneration. Furthermore, TSPO may not only be a microglia activation marker in early stage AD and DLB, but TSPO may also be used to monitor microglia dysfunction in the late stage of these diseases

Loss of intranetwork and internetwork resting state functional connections with Alzheimer\u27s disease progression

Alzheimer\u27s disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in AD severity from unaffected [clinical dementia rating (CDR) 0] to very mild (CDR 0.5) to mild (CDR 1). We observed loss of correlations within not only the DMN but other networks at CDR 0.5. Within the salience network (SAL), increases were seen between CDR 0 and CDR 0.5. However, at CDR 1, all networks, including SAL, exhibited reduced correlations. Specific networks were preferentially affected at certain CDR stages. In addition, cross-network relations were consistently lost with increasing AD severity. Our results demonstrate that AD is associated with widespread loss of both intranetwork and internetwork correlations. These results provide insight into AD pathophysiology and reinforce an integrative view of the brain\u27s functional organization

Evaluating cognitive relationships with resting-state and task-driven blood oxygen level-dependent variability

Recent functional magnetic resonance imaging studies have reported that moment-to-moment variability in the blood oxygen level-dependent (BOLD) signal is positively associated with task performance and, thus, may reflect a behaviorally sensitive signal. However, it is not clear whether estimates of resting-state and task-driven BOLD variability are differentially related to cognition, as they may be driven by distinct sources of variance in the BOLD signal. Moreover, other studies have suggested that age differences in resting-state BOLD variability may be particularly sensitive to individual differences in cardiovascular, rather than neural, factors. In this study, we tested relationships between measures of behavioral task performance and BOLD variability during both resting-state and task-driven runs of a Stroop and an animacy judgment task in a large, well-characterized sample of cognitively normal middle-aged to older adults. Resting-state BOLD variability was related to composite measures of global cognition and attentional control, but these relationships were eliminated after correction for age or cardiovascular estimates. In contrast, task-driven BOLD variability was related to attentional control measured both inside and outside the scanner, and importantly, these relationships persisted after correction for age and cardiovascular measures. Overall, these results suggest that BOLD variability is a behaviorally sensitive signal. However, resting-state and task-driven estimates of BOLD variability may differ in the degree to which they are sensitive to age-related, cardiovascular, and neural mechanisms

El arte en los tiempos modernos y actuales [Material gráfico proyectable]

Contiene: 1. Berlín, El mundo antiguo, por Schinkel ; 2. Munich. Ruhmeshalle y Baviera ; 3. Karlsruhe, La puerta de Ettligen ; 4. Vienna [sic], el parlamento ; 5. Canova, Venus ; 6. Canova, Sepulcro de la Archiduquesa María Cristina ; 7. Thorwaldsen, Jason ; 8. Thorwaldsen, Monumento a Schiller en Stuttgart ; 9. Thorwalden, Cristo dando la bendición ; 10. Dannecker, Ariadne ; 11. Dannecker, Busto de Schiller ; 12. Luis Hofer, Domando caballos ; 13. Rauch, Vistoria tirando coronas ; 14. David, El juramento de los Horacios ; 15. David, Retrato de Madame Recamier ; 16. Gérard, Retrato de Madame Récamier ; 17. Prud'hon, El rapto de Psiquis ; 18. Schick, David delante de Saúl ; 19. Angélica Kaufmann, Sibila ; 20. Tischbein, Goethe en Roma ; 21. Carlos José Stieler, Goethe ; 22. Reynolds, Musidora ; 23. Gainsborough, El muchacho azul ; 24. Lawrence, La condesa Gower con su niño ; 25. Francisco de Goya, Joven española ; 26. Delacroix, Dante y Virgilio ; 27. Overbeck, La curación de enfermos ; 28. Fuehrich, Jesús bendiciendo a los niños ; 29. Cornelius, Los ginetes del Apocalipsis ; 30. Mauricio de Schwind, El caballero de Falkenstein ; 31. Mauricio de Schwind, vista parcial de "Los siete cuervos" ; 32. Luis Richter, Cortejo nupcial ; 33. Luis Richter, Vida infantil ; 34. Delaroche, Napoleón en Fointenebleau ; 36. Piloty, Seni junto al cadaver de Wallenstein ; 37. Defregger, El último llamamiento ; 38. A. v. Werner, La capitulación de Sedán ; 39. Neuville, Los últimos cartuchos ; 40. Rjepin, Volviendo de Siberia ; 41. Meissonier, la retirada de Napoleón ; 42. Haug, AuroraContiene: 43. Vautier, En la casa mortuoria ; 44. Schuez, El descanso de los segadores ; 45. Claude Lorrain, Paisaje con la huida de la Santa Familia ; 46. Jacobo Ruisdael, Paisaje de pantanos ; 47. Hobbema, Calle en Middelharnis ; 48. Van der Velde, El cañonazo ; 49. Turner, Paisaje veneciano ; 50. Teodoro Rousseau, Paisaje con árboles ; 51. Corot, Paisaje ; 52. Millet, Segadoras ; 53. Preller, Paisaje de la Odisea ; 54. Andreas Achenbach, Tormenta ; 55. Degas, Bailarina ; 56. Otto Reiniger, El valle de Feuerbach ; 57. Gustavo Kampmann, Luna naciente ; 58. Federico Kallmorgen, Al trabajo ; 59. Max Liebermann, Tejedoras ; 60. Carlos Grethe, Pescadores de langostinos ; 61. Conde de Kalkreuth, Espigadoras ; 62. Heinrich Zuegel, Sol de primavera ; 63. Anselmo Feuerbach, Efigenia ; 64. Adolfo Menzel, Federico el Grande ; 65. Franz Lenbach, Bismarck ; 66. Hubert Herkomer, Señora de blanco ; 67. Ernst Rietschel, Piedad ; 68. Ernst Rietschel, Monumento a Goethe y Schiller ; 69. Schilling, Relieve del monumento de Niederwald ; 70. Otto Lessing, Portadores de la Cruz ; 71. Luis Habich, Muchacho rezando ; 72. Daniel Stocker, Figura de fuente ; 73. G. A. Bredow, Grupo con toro de la fuente monumental en Buenos Aires ; 74. Hugo Lederer, Monumento a Bismarck ; 75. Carpeaux, La danza ; 76. Henry Chapu, Juana de Arco ; 77. Augusto Rodin, El pensador ; 78. Albert Bartolomé, Monumento a los muertos ; 79. F. A. El león de Belfort ; 80. Constantin Meunier, Minero ; 81. Alfred Messel, La casa comercial de Wertheim ; 82. Bruno Schmitz, Monumento de la batalla de las naciones ; 83. Bonatz y Scholer, Estación principal de StuttgartCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2015Tit. y mención de responsabilidad tomados del catálogo de Cultura.Existe otra edición con igual numeración en alemán.Según DNB (Deutsche National Bibliothek), 02/07/2008, este editor estuvo activo ca. 1922-1940.El distribuidor en España de estas placas era Cultura Eimler - Basanta - Haase (Madrid)Mención de serie tomada del catálogo del distribuidor Cultura

Radiolabeled 6-(2, 3-dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A potential radiotracer for measuring and imaging MTH1

MTH1 (MutT homolog 1) or NUDT1 (Nudix Hydrolase 1), also known as oxidized purine nucleoside triphosphatase, has potential as a biomarker for monitoring cancer progression and quantifying target engagement for relevant therapies. In this study, we validate one MTH1 inhibitor TH287 as a PET MTH1 radiotracer. TH287 was radiolabeled with tritium and the binding of

Local and distributed PiB accumulation associated with development of preclinical Alzheimer\u27s disease

Amyloid-beta plaques are a hallmark of Alzheimer\u27s disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years follow-up, 16 participants with a previously normal PiB scan had conversion to PiB scans consistent with preclinical AD. We investigated the multivariate relationship (canonical correlation) between baseline and follow-up PiB topographies. Furthermore, we used penalized regression to investigate the added information derived from PiB topography compared to summary measures. PiB accumulation can be local, that is, a topography predicting the same topography in the future, and/or distributed, that is, one topography predicting another. Both local and distributed PiB accumulation was associated with conversion of PiB status. Additionally, elements of the multivariate topography, and not the commonly used summary scalar, correlated with future PiB changes. Consideration of the entire multivariate PiB topography provides additional information regarding the development of amyloid-beta pathology in very early preclinical AD