Paper Session I-B - Science Payloads

The Flight Systems Division at NASA Headquarters in Washington, D.C., has overall management responsibility for OSSA Spacelab and Shuttle-attached payload flight programs. These programs include a variety of science and applications investigations carried in and on Shuttle payload carriers such as Spacelab modules and pallets, Multipurpose Equipment Support Structures (MPESS), Get Away Special (GAS) canisters, and Hitchhiker-G equipment platforms (see Figure 1). In addition to the payload bay experiment carriers shown in Figure 1, science and applications experiments can be flown in standard stowage lockers in the crew compartment middeck. Locker space for experiments in the crew compartment is at a premium because these lockers must also contain food, clothing, crew personal effects, camera equipment, tools, etc. In an effort to maximize Shuttle science accommodations, a Middeck Accommodations Rack (MAR) that will provide space for an addition three middeck experiment lockers (and assorted stowage) has recently been developed (see Figure 2). The MAR will replace the Orbiter galley on selected flights, with the galley being reconfigured in a smaller form in lockers on the forward bulkhead of the middeck. A major advantage of the MAR system is its modularity, allowing for accommodation of odd- or large-sized experiments which would not normally fit into middeck locker space (see Figure 3)

Life Sciences Centrifuge Facility assessment

This report provides an assessment of the status of the Centrifuge Facility being developed by ARC for flight on the International Space Station Alpha. The assessment includes technical status, schedules, budgets, project management, performance of facility relative to science requirements, and identifies risks and issues that need to be considered in future development activities

Polar Topside Ionosphere During Geomagnetic Storms: Comparison of ISIS-II With TDIM

Space weather deposits energy into the high polar latitudes, primarily via Joule heating that is associated with the Poynting flux electromagnetic energy flow between the magnetosphere and ionosphere. One way to observe this energy flow is to look at the ionospheric electron density profile (EDP), especially that of the topside. The altitude location of the ionospheric peak provides additional information on the net field‐aligned vertical transport at high latitudes. To date, there have been few studies in which physics‐based ionospheric model storm simulations have been compared with topside EDPs. A rich database of high‐latitude topside ionograms obtained from polar orbiting satellites of the International Satellites for Ionospheric Studies (ISIS) program exists but has not been utilized in comparisons with physics‐based models. Of specific importance is that the Alouette/ISIS topside EDPs spanned the timeframe from 1962 to 1983, a period that experienced very large geomagnetic storms. We use a physics‐based ionospheric model, the Utah State University Time Dependent Ionospheric Model (TDIM), to simulate ionospheric EDPs for quiet and storm high‐latitude passes of ISIS‐II for two geomagnetic storms. This initial study finds that under quiet conditions there is good agreement between model and observations. During disturbed conditions, however, a large difference is seen between model and observations. The model limitation is probably associated with the inability of its topside boundary to replicate strong outflow conditions. As a result, modeling of the ionospheric outflows needs to be extended well into the magnetosphere, thereby moving the upper boundary much higher and requiring the use of polar wind models

Sodium oxybate therapy provides multidimensional improvement in fibromyalgia: results of an international phase 3 trial

Background: Fibromyalgia is characterised by chronic musculoskeletal pain and multiple symptoms including fatigue, multidimensional function impairment, sleep disturbance and tenderness. Along with pain and fatigue, non-restorative sleep is a core symptom of fibromyalgia. Sodium oxybate (SXB) is thought to reduce non-restorative sleep abnormalities. This study evaluated effects of SXB on fibromyalgia-related pain and other symptoms. Methods: 573 patients with fibromyalgia according to 1990 American College of Rheumatology criteria were enrolled at 108 centres in eight countries. Subjects were randomly assigned to placebo, SXB 4.5 g/night or SXB 6 g/night. The primary efficacy endpoint was the proportion of subjects with ≥30% reduction in pain visual analogue scale from baseline to treatment end. Other efficacy assessments included function, sleep quality, effect of sleep on function, fatigue, tenderness, health-related quality of life and subject's impression of change in overall wellbeing. Results: Significant improvements in pain, sleep and other symptoms associated with fibromyalgia were seen in SXB treated subjects compared with placebo. The proportion of subjects with ≥30% pain reduction was 42.0% for SXB4.5 g/night (p=0.002) and 51.4% for SXB6 g/night (p<0.001) versus 26.8% for placebo. Quality of sleep (Jenkins sleep scale) improved by 20% for SXB4.5 g/night (p≤0.001) and 25% for SXB6 g/night (p≤0.001) versus 0.5% for placebo. Adverse events with an incidence ≥5% and twice placebo were nausea, dizziness, vomiting, insomnia, anxiety, somnolence, fatigue, muscle spasms and peripheral oedema. Conclusion: These results, combined with findings from previous phase 2 and 3 studies, provide supportive evidence that SXB therapy affordsimportant benefits across multiple symptoms in subjects with fibromyalgia

A Milk-Borne Epidemic of Septic Sore Throat in Portland, Oregon

11 p. Reprinted from: Journal of the American Medical Association, June 2, 1923, Vol. 80, pp. 1608-1612.Print copies of this title are available through the UO Libraries under the call number: KNIGHT 616.31 B443; KNIGHT 378.795 OZm4c; and: SCA OrColl 378.795 OZm4c

Antigen depot is not required for alum adjuvanticity

Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation and subsequent T- and B-cell responses, this has never been formally proven. To examine antigen persistence, we used the chimeric fluorescent protein EαGFP, which allows assessment of antigen presentation in situ, using the Y-Ae antibody. We demonstrate that alum and/or CpG adjuvants induced similar uptake of antigen, and in all cases, GFP signal did not persist beyond 24 h in draining lymph node antigen-presenting cells. Antigen presentation was first detectable on B cells within 6–12 h of antigen administration, followed by conventional dendritic cells (DCs) at 12–24 h, then finally plasmacytoid DCs at 48 h or later. Again, alum and/or CpG adjuvants did not have an effect on the magnitude or sequence of this response; furthermore, they induced similar antigen-specific T-cell activation in vivo. Notably, removal of the injection site and associated alum depot, as early as 2 h after administration, had no appreciable effect on antigen-specific T- and B-cell responses. This study clearly rules out a role for depot formation in alum adjuvant activity

An entangled two photon source using biexciton emission of an asymmetric quantum dot in a cavity

A semiconductor based scheme has been proposed for generating entangled photon pairs from the radiative decay of an electrically-pumped biexciton in a quantum dot. Symmetric dots produce polarisation entanglement, but experimentally-realised asymmetric dots produce photons entangled in both polarisation and frequency. In this work, we investigate the possibility of erasing the `which-path' information contained in the frequencies of the photons produced by asymmetric quantum dots to recover polarisation-entangled photons. We consider a biexciton with non-degenerate intermediate excitonic states in a leaky optical cavity with pairs of degenerate cavity modes close to the non-degenerate exciton transition frequencies. An open quantum system approach is used to compute the polarisation entanglement of the two-photon state after it escapes from the cavity, measured by the visibility of two-photon interference fringes. We explicitly relate the two-photon visibility to the degree of Bell-inequality violation, deriving a threshold at which Bell-inequality violations will be observed. Our results show that an ideal cavity will produce maximally polarisation-entangled photon pairs, and even a non-ideal cavity will produce partially entangled photon pairs capable of violating a Bell-inequality.Comment: 16 pages, 10 figures, submitted to PR

Comparison of Instantaneous and Constant-Rate Stream Tracer Experiments Through Parametric Analysis of Residence Time Distributions

Artificial tracers are frequently employed to characterize solute residence times in stream systems and infer the nature of water retention. When the duration of tracer application is different between experiments, tracer breakthrough curves at downstream locations are difficult to compare directly. We explore methods for deriving stream solute residence time distributions (RTD) from tracer test data, allowing direct, non-parametric comparison of results from experiments of different durations. Paired short- and long-duration field experiments were performed using instantaneous and constant-rate tracer releases, respectively. The experiments were conducted in two study reaches that were morphologically distinct in channel structure and substrate size. Frequency- and time domain deconvolution techniques were used to derive RTDs from the resulting tracer concentrations. Comparisons of results between experiments of different duration demonstrated few differences in hydrologic retention characteristics inferred from short- and long-term tracer tests. Because non-parametric RTD analysis does not presume any shape of the distribution, it is useful for comparisons across tracer experiments with variable inputs and for validations of fundamental transport model assumptions