Healthcare systems: what do we want?

Учебная дисциплина «Актуальные проблемы биотехнологии» относится к специальным дисциплинам по выбору студента компонента УВО цикла специальных дисциплин учебных планов. Курс включает рассмотрение теоретических вопросов, положенных в основу организации биотехнологического процесса, роль биообъекта, как кардинального элемента любого биотехнологического производства, закономерности развития клеточных популяций и межклеточных взаимоотношений, основные принципы и уровни регуляции метаболизма продуцента, генетическую детерминированность и способы воздействия на пути биосинтеза целевого продукта. Особое внимание уделяется рассмотрению связей между достижения-ми в области фундаментальных наук (микробиология, молекулярная генетика, молекулярная биология и т.п.) и прикладными аспектами их использования в решении актуальных задач современного общества. Программа курса составлена с учетом межпредметных связей со смежным дисциплинами биологического профиля («Микробиология», «Вирусология», «Иммунология», «Биохимия») и др. Программа построена по блочно-модульному типу, что предполагает выделение основных разделов курса. Содержание и объем учебного материала по каждому модулю позволяет студентам свободно ориентироваться в изучаемых вопросах

Mais médicos: melhor atenção à saúde da população?

Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaWorld Medical AssociationUniversidade de São Paulo Faculdade de Medicina Hospital das ClínicasScientific Director of Associação Paulista de MedicinaUNIFESP, EPMSciEL

Peripheral pulmonary artery aneurysm presenting as a solitary pulmonary nodule

We report the case of a 63-year-old female patient who was evaluated due to a solitary pulmonary nodule. The final diagnosis was a solitary peripheral pulmonary artery saccular aneurysm. The patient was submitted to a pulmonary lobectomy with excellent recovery. Peripheral pulmonary artery aneurysms that arise from segmental or intrapulmonary branches are extremely rare, and their management is still controversial

Effectiveness and safety of outpatient pleurodesis in patients with recurrent malignant pleural effusion and low performance status

OBJECTIVES: To evaluate the effectiveness and safety of pleurodesis carried out entirely on an outpatient basis in patients with recurrent malignant pleural effusions and Karnofsky Performance Status scores <70. METHODS: This study was a prospective trial comprising patients with symptomatic recurrent malignant pleural effusion and Karnofsky Performance Status scores <70 but &gt;30. All selected patients underwent pleural catheter placement (14 Fr) in an outpatient facility. When chest radiography revealed post-drainage lung expansion of &gt;90%, pleurodesis (3 g of talc) was performed. Catheters were maintained until the daily output was ,100 mL/day. The patients were evaluated in the first month and every three months thereafter for fluid recurrence, the need for additional procedures, and complications. RESULTS: During the study period (January 2005 to July 2007), 64 patients (24 men, 40 women), with an average age of 61.4 years, underwent elective chest tube drainage. Primary sites of the underlying malignancy were breast (27), lung (22), and others (15). Sixty-six pleural catheters were placed (bilaterally in 2 patients), and 52 talc pleurodesis procedures were performed. Fourteen patients had a trapped lung and were excluded from the trial. No complications were observed during catheter placement or pleurodesis. Post-pleurodesis complications included catheter obstruction (4 patients) and empyema (1). The average drainage time was 9.9 days. The recurrence rate observed in patients that were alive 30 days after pleurodesis was 13.9% (5/36 patients). Six patients required additional procedures after the pleurodesis. The average survival time was 101 days. CONCLUSION: In this study, talc pleurodesis was safely performed in an outpatient setting with good efficacy and a reasonable complication rate, thereby avoiding hospital admission