The Fermi Problem in Discrete Systems

The Fermi two-atom problem illustrates an apparent causality violation in Quantum Field Theory which has to do with the nature of the built in correlations in the vacuum. It has been a constant subject of theoretical debate and discussions during the last few decades. Nevertheless, although the issues at hand could in principle be tested experimentally, the smallness of such apparent violations of causality in Quantum Electrodynamics prevented the observation of the predicted effect. In the present paper we show that the problem can be simulated within the framework of discrete systems that can be manifested, for instance, by trapped atoms in optical lattices or trapped ions. Unlike the original continuum case, the causal structure is no longer sharp. Nevertheless, as we show, it is possible to distinguish between "trivial" effects due to "direct" causality violations, and the effects associated with Fermi's problem, even in such discrete settings. The ability to control externally the strength of the atom-field interactions, enables us also to study both the original Fermi problem with "bare atoms", as well as correction in the scenario that involves "dressed" atoms. Finally, we show that in principle, the Fermi effect can be detected using trapped ions.Comment: Second version - minor change

Cysteine-to-lysine transfer antibody fragment conjugation

The modification of lysine residues with acylating agents has represented a ubiquitous approach to the construction of antibody conjugates, with the resulting amide bonds being robustly stable and clinically validated. However, the conjugates are highly heterogeneous, due to the presence of numerous lysines on the surface of the protein, and greater control of the sites of conjugation are keenly sought. Here we present a novel approach to achieve the targeted modification of lysines distal to an antibody fragment's binding site, using a disulfide bond as a temporary ‘hook’ to deliver the acylating agent. This cysteine-to-lysine transfer (CLT) methodology offers greatly improved homogeneity of lysine conjugates, whilst retaining the advantages offered by the formation of amide linkages

Remote operations and interactions for systems of arbitrary dimensional Hilbert space: a state-operator approach

We present a systematic simple method for constructing deterministic remote operations on single and multiple systems of arbitrary discrete dimensionality. These operations include remote rotations, remote interactions and measurements. The resources needed for an operation on a two-level system are one ebit and a bidirectional communication of two cbits, and for an n-level system, a pair of entangled n-level particles and two classical ``nits''. In the latter case, there are $n-1$ possible distinct operations per one n-level entangled pair. Similar results apply for generating interaction between a pair of remote systems and for remote measurements. We further consider remote operations on $N$ spatially distributed systems, and show that the number of possible distinct operations increases here exponentially, with the available number of entangled pairs that are initial distributed between the systems. Our results follow from the properties of a hybrid state-operator object (``stator''), which describes quantum correlations between states and operations.Comment: 18 pages, 3 figures, typo correction

Hawking Radiation on an Ion Ring in the Quantum Regime

This paper discusses a recent proposal for the simulation of acoustic black holes with ions. The ions are rotating on a ring with an inhomogeneous, but stationary velocity profile. Phonons cannot leave a region, in which the ion velocity exceeds the group velocity of the phonons, as light cannot escape from a black hole. The system is described by a discrete field theory with a nonlinear dispersion relation. Hawking radiation is emitted by this acoustic black hole, generating entanglement between the inside and the outside of the black hole. We study schemes to detect the Hawking effect in this setup.Comment: 42 pages (one column), 17 figures, published revised versio

Topological Wilson-loop area law manifested using a superposition of loops

We introduce a new topological effect involving interference of two meson loops, manifesting a path-independent topological area dependence. The effect also draws a connection between quark confinement, Wilson-loops and topological interference effects. Although this is only a gedanken experiment in the context of particle physics, such an experiment may be realized and used as a tool to test confinement effects and phase transitions in quantum simulation of dynamic gauge theories.Comment: Superceding arXiv:1206.2021v1 [quant-ph

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Disulfide bridging offers a convenient approach to generate site-selective antibody conjugates from native antibodies. To optimise the reagents available to achieve this strategy, we describe here the use of dibromomaleimides designed to undergo accelerated post-conjugation hydrolysis. Conjugation and hydrolysis, which serve to 'lock' the conjugates as robustly stable maleamic acids, is achieved in just over 1 h. This dramatic acceleration is also shown to infer significant improvements in homogeneity, as demonstrated by mass spectrometry analysis

Comparative performance of selected variability detection techniques in photometric time series

Photometric measurements are prone to systematic errors presenting a challenge to low-amplitude variability detection. In search for a general-purpose variability detection technique able to recover a broad range of variability types including currently unknown ones, we test 18 statistical characteristics quantifying scatter and/or correlation between brightness measurements. We compare their performance in identifying variable objects in seven time series data sets obtained with telescopes ranging in size from a telephoto lens to 1m-class and probing variability on time-scales from minutes to decades. The test data sets together include lightcurves of 127539 objects, among them 1251 variable stars of various types and represent a range of observing conditions often found in ground-based variability surveys. The real data are complemented by simulations. We propose a combination of two indices that together recover a broad range of variability types from photometric data characterized by a wide variety of sampling patterns, photometric accuracies, and percentages of outlier measurements. The first index is the interquartile range (IQR) of magnitude measurements, sensitive to variability irrespective of a time-scale and resistant to outliers. It can be complemented by the ratio of the lightcurve variance to the mean square successive difference, 1/h, which is efficient in detecting variability on time-scales longer than the typical time interval between observations. Variable objects have larger 1/h and/or IQR values than non-variable objects of similar brightness. Another approach to variability detection is to combine many variability indices using principal component analysis. We present 124 previously unknown variable stars found in the test data.Comment: 29 pages, 8 figures, 7 tables; accepted to MNRAS; for additional plots, see http://scan.sai.msu.ru/~kirx/var_idx_paper

First results of the Kourovka Planet Search: discovery of transiting exoplanet candidates in the first three target fields

We present the first results of our search for transiting exoplanet candidates as part of the Kourovka Planet Search (KPS) project. The primary objective of the project is to search for new hot Jupiters which transit their host stars, mainly in the Galactic plane, in the $R_c$ magnitude range of 11 to 14 mag. Our observations were performed with the telescope of the MASTER robotic network, installed at the Kourovka astronomical observatory of the Ural Federal University (Russia), and the Rowe-Ackermann Schmidt Astrograph, installed at the private Acton Sky Portal Observatory (USA). As test observations, we observed three celestial fields of size $2\times2$ deg$^2$ during the period from 2012 to 2015. As a result, we discovered four transiting exoplanet candidates among the 39000 stars of the input catalogue. In this paper, we provide the description of the project and analyse additional photometric, spectral, and speckle interferometric observations of the discovered transiting exoplanet candidates. Three of the four transiting exoplanet candidates are most likely astrophysical false positives, while the nature of the fourth (most promising) candidate remains to be ascertained. Also, we propose an alternative observing strategy that could increase the project's exoplanet haul.Comment: 11 pages, 16 figures; Accepted for publication in Monthly Notices of the Royal Astronomical Society 201

KELT-18b: Puffy Planet, Hot Host, Probably Perturbed

We report the discovery of KELT-18b, a transiting hot Jupiter in a 2.87-day orbit around the bright ( V = 10.1), hot, F4V star BD+60 1538 (TYC 3865-1173-1). We present follow-up photometry, spectroscopy, and adaptive optics imaging that allow a detailed characterization of the system. Our preferred model fits yield a host stellar temperature of K and a mass of , situating it as one of only a handful of known transiting planets with hosts that are as hot, massive, and bright. The planet has a mass of , a radius of , and a density of , making it one of the most inflated planets known around a hot star. We argue that KELT-18b’s high temperature and low surface gravity, which yield an estimated ∼600 km atmospheric scale height, combined with its hot, bright host, make it an excellent candidate for observations aimed at atmospheric characterization. We also present evidence for a bound stellar companion at a projected separation of ∼1100 au, and speculate that it may have contributed to the strong misalignment we suspect between KELT-18\u27s spin axis and its planet’s orbital axis. The inferior conjunction time is 2457542.524998 ± 0.000416 (BJD TDB ) and the orbital period is 2.8717510 ± 0.0000029 days. We encourage Rossiter–McLaughlin measurements in the near future to confirm the suspected spin–orbit misalignment of this system

The KELT Follow-Up Network And Transit False-Positive Catalog: Pre-Vetted False Positives For TESS

The Kilodegree Extremely Little Telescope (KELT) project has been conducting a photometric survey of transiting planets orbiting bright stars for over 10 years. The KELT images have a pixel scale of ~23\u27\u27 pixel⁻¹—very similar to that of NASA\u27s Transiting Exoplanet Survey Satellite (TESS)—as well as a large point-spread function, and the KELT reduction pipeline uses a weighted photometric aperture with radius 3\u27. At this angular scale, multiple stars are typically blended in the photometric apertures. In order to identify false positives and confirm transiting exoplanets, we have assembled a follow-up network (KELT-FUN) to conduct imaging with spatial resolution, cadence, and photometric precision higher than the KELT telescopes, as well as spectroscopic observations of the candidate host stars. The KELT-FUN team has followed-up over 1600 planet candidates since 2011, resulting in more than 20 planet discoveries. Excluding ~450 false alarms of non-astrophysical origin (i.e., instrumental noise or systematics), we present an all-sky catalog of the 1128 bright stars (6 \u3c V \u3c 13) that show transit-like features in the KELT light curves, but which were subsequently determined to be astrophysical false positives (FPs) after photometric and/or spectroscopic follow-up observations. The KELT-FUN team continues to pursue KELT and other planet candidates and will eventually follow up certain classes of TESS candidates. The KELT FP catalog will help minimize the duplication of follow-up observations by current and future transit surveys such as TESS