400 research outputs found
Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/12/2015
- Field of study
Objective Platelets are increasingly implicated in processes beyond hemostasis and thrombosis, such as vascular remodeling. Members of the matrix metalloproteinase (MMP) family not only remodel the extracellular matrix but also modulate platelet function. Here, we made a systematic comparison of the roles of MMP family members in acute thrombus formation under flow conditions and assessed platelet-dependent collagenolytic activity over time. Approach and Results Pharmacological inhibition of MMP-1 or MMP-2 (human) or deficiency in MMP-2 (mouse) suppressed collagen-dependent platelet activation and thrombus formation under flow, whereas MMP-9 inhibition/deficiency stimulated these processes. The absence of MMP-3 was without effect. Interestingly, MMP-14 inhibition led to the formation of larger thrombi, which occurred independently of its capacity to activate MMP-2. Platelet thrombi exerted local collagenolytic activity capable of cleaving immobilized dye-quenched collagen and fibrillar collagen fibers within hours, with loss of the majority of the platelet adhesive properties of collagen as a consequence. This collagenolytic activity was redundantly mediated by platelet-associated MMP-1, MMP-2, MMP-9, and MMP-14 but occurred independently of platelet -granule release (Nbeal2(-/-) mice). The latter was in line with subcellular localization experiments, which indicated a granular distribution of MMP-1 and MMP-2 in platelets, distinct from -granules. Whereas MMP-9 protein could not be detected inside platelets, activated platelets did bind plasma-derived MMP-9 to their plasma membrane. Overall, platelet MMP activity was predominantly membrane-associated and influenced by platelet activation status. Conclusions Platelet-associated MMP-1, MMP-2, MMP-9, and MMP-14 differentially modulate acute thrombus formation and at later time points limit thrombus formation by exerting collagenolytic activity
Mechanisms Underlying Metabolic and Neural Defects in Zebrafish and Human Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/12/2009
- Field of study
In humans, mutations in electron transfer flavoprotein (ETF) or electron transfer flavoprotein dehydrogenase (ETFDH) lead to MADD/glutaric aciduria type II, an autosomal recessively inherited disorder characterized by a broad spectrum of devastating neurological, systemic and metabolic symptoms. We show that a zebrafish mutant in ETFDH, xavier, and fibroblast cells from MADD patients demonstrate similar mitochondrial and metabolic abnormalities, including reduced oxidative phosphorylation, increased aerobic glycolysis, and upregulation of the PPARG-ERK pathway. This metabolic dysfunction is associated with aberrant neural proliferation in xav, in addition to other neural phenotypes and paralysis. Strikingly, a PPARG antagonist attenuates aberrant neural proliferation and alleviates paralysis in xav, while PPARG agonists increase neural proliferation in wild type embryos. These results show that mitochondrial dysfunction, leading to an increase in aerobic glycolysis, affects neurogenesis through the PPARG-ERK pathway, a potential target for therapeutic intervention
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Individual common variants exert weak effects on the risk for autism spectrum disorders.
- Author
- Almeida Joana
- Anney Richard
- Bacchelli Elena
- Bailey Anthony J
- Baird Gillian
- Bolshakova Nadia
- Bolton Patrick F
- Bourgeron Thomas
- Brennan Sean
- Brian Jessica
- Bölte Sven
- Casey Jillian
- Conroy Judith
- Correia Catarina
- Corsello Christina
- Crawford Emily L
- de Jonge Maretha
- Delorme Richard
- Duketis Eftichia
- Duque Frederico
- Estes Annette
- Farrar Penny
- Fernandez Bridget A
- Folstein Susan E
- Fombonne Eric
- Gilbert John
- Gillberg Christopher
- Glessner Joseph T
- Green Andrew
- Green Jonathan
- Guter Stephen J
- Heron Elizabeth A
- Holt Richard
- Howe Jennifer L
- Hughes Gillian
- Hus Vanessa
- Igliozzi Roberta
- Jacob Suma
- Kenny Graham P
- Kim Cecilia
- Klei Lambertus
- Kolevzon Alexander
- Kustanovich Vlad
- Lajonchere Clara M
- Lamb Janine A
- Law-Smith Miriam
- Le Couteur Ann
- Leboyer Marion
- Leventhal Bennett L
- Liu Xiao-Qing
- Lombard Frances
- Lord Catherine
- Lotspeich Linda
- Lund Sabata C
- Magalhaes Tiago R
- Mantoulan Carine
- McDougle Christopher J
- Melhem Nadine M
- Merikangas Alison
- Minshew Nancy J
- Mirza Ghazala K
- Munson Jeff
- Noakes Carolyn
- Nygren Gudrun
- Pagnamenta Alistair T
- Papanikolaou Katerina
- Parrini Barbara
- Paton Tara
- Pickles Andrew
- Pinto Dalila
- Posey David J
- Poustka Fritz
- Ragoussis Jiannis
- Regan Regina
- Roberts Wendy
- Roeder Kathryn
- Roge Bernadette
- Rutter Michael L
- Schlitt Sabine
- Shah Naisha
- Sheffield Val C
- Soorya Latha
- Sousa Inês
- Stoppioni Vera
- Sykes Nuala
- Tancredi Raffaella
- Thompson Ann P
- Thomson Susanne
- Tryfon Ana
- Tsiantis John
- Van Engeland Herman
- Vincent John B
- Volkmar Fred
- Vorstman JAS
- Wallace Simon
- Wing Kirsty
- Wittemeyer Kerstin
- Wood Shawn
- Zurawiecki Danielle
- Zwaigenbaum Lonnie
- Publication venue
- eScholarship, University of California
- Publication date
- 01/11/2012
- Field of study
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest
Measuring α in the Early Universe: CMB Polarization, Reionization and the Fisher Matrix Analysis
- Author
- A. Melchiorri
- Avelino
- Avelino
- Avelino
- Avelino
- Barrow
- Battye
- Bean
- Bean
- Bennett
- Bond
- Bowen
- Bruscoli
- C. J. A. P. Martins
- Challinor
- Damour
- Damour
- Efstathiou
- Efstathiou
- Fisher
- Fujii
- G. Rocha
- Hannestad
- Hinshaw
- Holder
- Hu
- Hu
- Hu
- Hu
- Ivanchik
- Jungman
- Jungman
- Kamionkowski
- Kamionkowski
- Kaplinghat
- Kaplinghat
- Kinney
- Knox
- Kogut
- Kolb
- Kosowsky
- Kovac
- Marion
- Martins
- Martins
- Martins
- Melchiorri
- Melchiorri
- Mota
- Murphy
- P. P. Avelino
- P. T. P. Viana
- Peiris
- Polchinski
- Press
- R. Bean
- R. Trotta
- Santiago
- Seljak
- Sigurdson
- Spergel
- Tegmark
- Trotta
- Uzan
- Verde
- Webb
- Webb
- Will
- Zaldarriaga
- Zaldarriaga
- Publication venue
- 'Wiley'
- Publication date
- 08/09/2003
- Field of study
We present a detailed analysis of present and future Cosmic Microwave
Background constraints of the value of the fine-structure constant, α.
We carry out a more detailed analysis of the WMAP first-year data, deriving
state-of-the-art constraints on α and discussing various other issues,
such as the possible hints for the running of the spectral index. We find, at
95% C.L. that 0.95<αdec/α0<1.02. Setting dnS/dlnk=0, yields 0.94<αdec/α0<1.01 as previously
reported. We find that a lower value of α/α0 makes a value of dnS/dlnk=0 more compatible with the data. We also perform a thorough Fisher
Matrix Analysis (including both temperature and polarization, as well as
α and the optical depth τ), in order to estimate how future CMB
experiments will be able to constrain α and other cosmological
parameters. We find that Planck data alone can constrain τ with a accuracy
of the order 4% and that this constraint can be as small as 1.7% for an ideal
cosmic variance limited experiment. Constraints on α are of the order
0.3% for Planck and can in principle be as small as 0.1% using CMB data alone -
tighter constraints will require further (non-CMB) priors.Comment: 29 pages, 11 figures, 15 tables, submitted to MNRAS. Higher
resolution figures available at http://www.mrao.cam.ac.uk/~graca/alph
Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data
- Author
- Abbott R
- Abbott T
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari R
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Akutsu T
- Albanesi S
- Albayati A
- Allocca A
- Altamirano D
- Altin P
- Amato A
- Anand C
- Anand S
- Ananyeva A
- Anderson S
- Anderson W
- Ando M
- Andrade T
- Andres N
- Andrić T
- Angelova S
- Ansoldi S
- Antelis J
- Antier S
- Appert S
- Arai K
- Arai Y
- Araki S
- Araya A
- Araya M
- Areeda J
- Arellano FP
- Aritomi N
- Arnaud N
- Aronson S
- Arun K
- Arène M
- Asada H
- Asali Y
- Ashton G
- Aso Y
- Assiduo M
- Aston S
- Astone P
- Aubin F
- Austin C
- Babak S
- Badaracco F
- Bader M
- Badger C
- Bae S
- Bae Y
- Baer A
- Bagnasco S
- Bai Y
- Baiotti L
- Baird J
- Bajpai R
- Ball M
- Ballardin G
- Ballmer S
- Balsamo A
- Baltus G
- Banagiri S
- Bankar D
- Barayoga J
- Barbieri C
- Barish B
- Barker D
- Barneo P
- Barone F
- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Bartlett J
- Barton M
- Bartos I
- Bassiri R
- Basti A
- Bawaj M
- Bayley J
- Baylor A
- Bazzan M
- Bedakihale V
- Bejger M
- Belahcene I
- Benedetto V
- Beniwal D
- Bennett T
- Bentley J
- BenYaala M
- Bergamin F
- Berger B
- Bernuzzi S
- Bersanetti D
- Bertolini A
- Betzwieser J
- Beveridge D
- Bhandare R
- Bhardwaj U
- Bhattacharjee D
- Bhaumik S
- Bilenko I
- Billingsley G
- Bini S
- Birney R
- Birnholtz O
- Biscans S
- Bischi M
- Biscoveanu S
- Bisht A
- Biswas B
- Bitossi M
- Bizouard M
- Blackburn J
- Blair C
- Blair D
- Blair R
- Bobba F
- Bode N
- Boer M
- Bogaert G
- Boldrini M
- Bonavena L
- Bondu F
- Bonilla E
- Bonnand R
- Booker P
- Boom B
- Bork R
- Boschi V
- Bose N
- Bose S
- Bossilkov V
- Boudart V
- Bouffanais Y
- Bozzi A
- Bradaschia C
- Brady P
- Bramley A
- Branch A
- Branchesi M
- Brau J
- Breschi M
- Briant T
- Briggs J
- Brillet A
- Brinkmann M
- Brockill P
- Brooks A
- Brooks J
- Brown D
- Brunett S
- Bruno G
- Bruntz R
- Bryant J
- Bulik T
- Bult P
- Bulten H
- Buonanno A
- Buscicchio R
- Buskulic D
- Bustillo JC
- Buy C
- Byer R
- Bécsy B
- Cadonati L
- Cagnoli G
- Cahillane C
- Callaghan J
- Callister T
- Calloni E
- Cameron J
- Camp J
- Canepa M
- Canevarolo S
- Cannavacciuolo M
- Cannon K
- Canton TD
- Cao H
- Cao Z
- Capocasa E
- Capote E
- Carapella G
- Carbognani F
- Carlin J
- Carney M
- Carpinelli M
- Carrillo G
- Carullo G
- Carver T
- Casentini C
- Castaldi G
- Caudill S
- Cavaglià M
- Cavalier F
- Cavalieri R
- Ceasar M
- Cella G
- Cerdá-Durán P
- Cesarini E
- Chaibi W
- Chakrabarty D
- Chakravarti K
- Champion E
- Chan C
- Chan K
- Chan M
- Chandra K
- Chanial P
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee C
- Chatterjee D
- Chaturvedi M
- Chaty S
- Chen C
- Chen H
- Chen J
- Chen K
- Chen X
- Chen Y
- Chen Z
- Cheng H
- Cheong C
- Cheung H
- Chia H
- Chiadini F
- Chiang C
- Chiarini G
- Chierici R
- Chincarini A
- Chiofalo M
- Chiummo A
- Cho G
- Cho H
- Choudhary R
- Choudhary S
- Christensen N
- Chu H
- Chu Q
- Chu Y
- Chua S
- Chung K
- Ciani G
- Ciecielag P
- Cieślar M
- Cifaldi M
- Ciobanu A
- Ciolfi R
- Cipriano F
- Cirone A
- Clara F
- Clark E
- Clark J
- Clarke L
- Clearwater P
- Clesse S
- Cleva F
- Coccia E
- Codazzo E
- Cohadon P
- Cohen D
- Cohen L
- Colleoni M
- Collette C
- Colombo A
- Colpi M
- Compton C
- Constancio M
- Conti L
- Cooper S
- Corban P
- Corbitt T
- Cordero-Carrión I
- Corezzi S
- Corley K
- Cornish N
- Corre D
- Corsi A
- Cortese S
- Costa C
- Cotesta R
- Coughlin M
- Coulon J
- Countryman S
- Cousins B
- Couvares P
- Coward D
- Cowart M
- Coyne D
- Coyne R
- Creighton J
- Creighton T
- Criswell A
- Croquette M
- Crowder S
- Cudell J
- Cullen T
- Cumming A
- Cummings R
- Cunningham L
- Cuoco E
- Curyło M
- Dabadie P
- Dall’Osso S
- Dana A
- DaneshgaranBajastani L
- Danilishin S
- Danzmann K
- Darsow-Fromm C
- Dasgupta A
- Datrier L
- Datta S
- Dattilo V
- Dave I
- Davier M
- Davies G
- Davis D
- Davis M
- Daw E
- De Laurentis M
- De Lillo F
- De Lillo N
- De Matteis F
- De Pietri R
- De Rosa R
- De Rossi C
- De Simone R
- Dean R
- DeBra D
- Deenadayalan M
- Degallaix J
- Del Favero V
- Del Pozzo W
- Deléglise S
- DeMarchi L
- Demos N
- Dent T
- Depasse A
- DeSalvo R
- Dhurandhar S
- Di Fiore L
- Di Fronzo C
- Di Giorgio C
- Di Giovanni F
- Di Giovanni M
- Di Girolamo T
- Di Lieto A
- Di Pace S
- Di Palma I
- Di Renzo F
- Diaz JC
- Diaz-Ortiz M
- Didio N
- Dietrich T
- Ding B
- Divakarla A
- Dmitriev A
- Doctor Z
- Donovan F
- Dooley K
- Doravari S
- Dorrington I
- Drago M
- Driggers J
- Drori Y
- Ducoin J
- Dupej P
- Durante O
- Duverne P
- Dwyer S
- Dálya G
- Díaz M
- D’Angelo B
- D’Antonio S
- D’Emilio V
- D’Onofrio L
- D’Urso D
- e Melo IT
- Eassa C
- Easter P
- Ebersold M
- Eckhardt T
- Eddolls G
- Edelman B
- Edo T
- Edy O
- Effler A
- Eguchi S
- Eichholz J
- Eikenberry S
- Eisenmann M
- Eisenstein R
- Ejlli A
- Engelby E
- Enomoto Y
- Errico L
- Essick R
- Estellés H
- Estevez D
- Etienne Z
- Etzel T
- Evans M
- Evans T
- Ewing B
- Fafone V
- Fair H
- Fairhurst S
- Farah A
- Farinon S
- Farr B
- Farr W
- Farrow N
- Fauchon-Jones E
- Favaro G
- Favata M
- Fays M
- Fazio M
- Feicht J
- Fejer M
- Fenyvesi E
- Ferguson D
- Fernandez-Galiana A
- Ferrante I
- Ferreira T
- Fidecaro F
- Figura P
- Fiori I
- Fishbach M
- Fisher R
- Fittipaldi R
- Fiumara V
- Flaminio R
- Floden E
- Fong H
- Font J
- Fornal B
- Forsyth P
- Franke A
- Frasca S
- Frasconi F
- Frederick C
- Freed J
- Frei Z
- Freise A
- Frey R
- Fritschel P
- Frolov V
- Fronzé G
- Fujii Y
- Fujikawa Y
- Fukunaga M
- Fukushima M
- Fulda P
- Fyffe M
- Gabbard H
- Gadre B
- Gair J
- Gais J
- Galaudage S
- Gamba R
- Ganapathy D
- Ganguly A
- Gao D
- Gaonkar S
- Garaventa B
- García-Núñez C
- García-Quirós C
- Garufi F
- Gateley B
- Gaudio S
- Gayathri V
- Ge G
- Gemme G
- Gennai A
- George J
- Gerberding O
- Gergely L
- Gewecke P
- Ghonge S
- Ghosh A
- Ghosh S
- Giacomazzo B
- Giacoppo L
- Giaime J
- Giardina K
- Gibson D
- Gier C
- Giesler M
- Giri P
- Gissi F
- Glanzer J
- Gleckl A
- Godwin P
- Goetz E
- Goetz R
- Gohlke N
- Goncharov B
- González G
- Gopakumar A
- Gosselin M
- Gouaty R
- Gould D
- Grace B
- Grado A
- Granata M
- Granata V
- Grant A
- Gras S
- Grassia P
- Gray C
- Gray R
- Greco G
- Green A
- Green R
- Gretarsson A
- Gretarsson E
- Griffith D
- Griffiths W
- Griggs H
- Grignani G
- Grimaldi A
- Grimm S
- Grote H
- Grunewald S
- Gruning P
- Guerra D
- Guidi G
- Guimaraes A
- Guixé G
- Gulati H
- Guo H
- Guo Y
- Gupta A
- Gupta P
- Gustafson E
- Gustafson R
- Guzman F
- Ha S
- Haegel L
- Hagiwara A
- Haino S
- Halim O
- Hall E
- Hamilton E
- Hammond G
- Han W
- Haney M
- Hanks J
- Hanna C
- Hannam M
- Hannuksela O
- Hansen H
- Hansen T
- Hanson J
- Harder T
- Hardwick T
- Haris K
- Harms J
- Harry G
- Harry I
- Hartwig D
- Hasegawa K
- Haskell B
- Hasskew R
- Haster C
- Hattori K
- Haughian K
- Hayakawa H
- Hayama K
- Hayes F
- Healy J
- Heidmann A
- Heidt A
- Heintze M
- Heinze J
- Heinzel J
- Heitmann H
- Hellman F
- Hello P
- Helmling-Cornell A
- Hemming G
- Hendry M
- Heng I
- Hennes E
- Hennig J
- Hennig M
- Hernandez A
- Hernandez IM
- Heurs M
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- Hill P
- Himemoto Y
- Hines A
- Hiranuma Y
- Hirata N
- Hirose E
- Ho W
- Hochheim S
- Hofman D
- Hohmann J
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- Hsu Y
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- Hughey B
- Hui D
- Hui V
- Husa S
- Huttner S
- Huxford R
- Huynh-Dinh T
- Hübner M
- Ide S
- Idzkowski B
- Iess A
- Ikenoue B
- Imam S
- Inayoshi K
- Ingram C
- Inoue Y
- Ioka K
- Isi M
- Isleif K
- Ito K
- Itoh Y
- Iyer B
- Izumi K
- JaberianHamedan V
- Jacqmin T
- Jadhav S
- James A
- Jan A
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- Janquart J
- Janssens K
- Janthalur N
- Jaranowski P
- Jariwala D
- Jaume R
- Jenkins A
- Jenner K
- Jeon C
- Jeunon M
- Jia W
- Jin H
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- Jones A
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- Jung K
- Jung P
- Junker J
- Juste V
- Kaihotsu K
- Kajita T
- Kakizaki M
- Kalaghatgi C
- Kalogera V
- Kamai B
- Kamiizumi M
- Kanda N
- Kandhasamy S
- Kang G
- Kanner J
- Kao Y
- Kapadia S
- Kapasi D
- Karat S
- Karathanasis C
- Karki S
- Kashyap R
- Kasprzack M
- Kastaun W
- Katsanevas S
- Katsavounidis E
- Katzman W
- Kaur T
- Kawabe K
- Kawaguchi K
- Kawai N
- Kawasaki T
- Keitel D
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- Khadka S
- Khalili F
- Khan S
- Khazanov E
- Khetan N
- Khursheed M
- Kijbunchoo N
- Kim C
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- Kim K
- Kim W
- Kim Y
- Kimball C
- Kimura N
- Kinley-Hanlon M
- Kirchhoff R
- Kissel J
- Kita N
- Kitazawa H
- Kleybolte L
- Klimenko S
- Knee A
- Knowles T
- Knyazev E
- Koch P
- Koekoek G
- Kojima Y
- Kokeyama K
- Koley S
- Kolitsidou P
- Kolstein M
- Komori K
- Kondrashov V
- Kong A
- Kontos A
- Koper N
- Korobko M
- Kotake K
- Kovalam M
- Kozak D
- Kozakai C
- Kozu R
- Kringel V
- Krishnendu N
- Królak A
- Kuehn G
- Kuei F
- Kuijer P
- Kumar A
- Kumar P
- Kumar R
- Kume J
- Kuns K
- Kuo C
- Kuo H
- Kuromiya Y
- Kuroyanagi S
- Kusayanagi K
- Kuwahara S
- Kwak K
- Kéfélian F
- La Rosa I
- Lagabbe P
- Laghi D
- Lalande E
- Lam T
- Lamberts A
- Landry M
- Lane B
- Lang R
- Lange J
- Lantz B
- Lartaux-Vollard A
- Lasky P
- Laxen M
- Lazzarini A
- Lazzaro C
- Leaci P
- Leavey S
- Lecoeuche Y
- Lee H
- Lee J
- Lee K
- Lee R
- Lehmann J
- Lemaître A
- Leonardi M
- Leroy N
- Letendre N
- Levesque C
- Levin Y
- Leviton J
- Leyde K
- Li A
- Li B
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- Li K
- Li T
- Li X
- Lin C
- Lin F
- Lin H
- Lin LC
- Linde F
- Linker S
- Linley J
- Littenberg T
- Liu G
- Liu J
- Liu K
- Liu X
- Llamas F
- Llorens-Monteagudo M
- Lo R
- Lockwood A
- London L
- Longo A
- Lopez D
- Lorenzini M
- Loriette V
- Lormand M
- Losurdo G
- Lott T
- Lough J
- Lousto C
- Lovelace G
- Lucaccioni J
- Lumaca D
- Lundgren A
- Luo L
- Lynam J
- Lück H
- Macas R
- MacInnis M
- Macleod D
- MacMillan I
- Macquet A
- Magazzù C
- Magee R
- Maggiore R
- Magnozzi M
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data
- Author
- Abbott R
- Abe H
- Acernese F
- Ackley K
- Adhikari N
- Adhikari R
- Adkins V
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Ajith P
- Akutsu T
- Albanesi S
- Alfaidi R
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- Altin P
- Amato A
- Anand C
- Anand S
- Ananyeva A
- Anderson S
- Anderson W
- Ando M
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- Andrić T
- Andrés-Carcasona M
- Angelova S
- Ansoldi S
- Antelis J
- Antier S
- Apostolatos T
- Appavuravther E
- Appert S
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- Arai K
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- Arellano F
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- Ashton G
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- Fiori I
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
All-sky search for short gravitational-wave bursts in the third Advanced LIGO and Advanced Virgo run
- Author
- Abbott R
- Abbott T
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari R
- Adya V
- Affeldt C
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Constraints on the cosmic expansion history from GWTC-3
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley K.
- Adhikari N.
- Adhikari R.
- Adkins V.
- Adya V.
- Affeldt C.
- Agarwal D.
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- Publication venue
- Publication date
- 19/11/2021
- Field of study
We use 47 gravitational-wave sources from the Third LIGO-Virgo-KAGRA Gravitational-Wave Transient Catalog (GWTC-3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0. Each gravitational-wave (GW) signal provides the luminosity distance to the source and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34M⊙, followed by a drop-off. Assuming this mass scale does not evolve with redshift results in a H(z) measurement, yielding H0=68−7+12kms−1Mpc−1 (68% credible interval) when combined with the H0 measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0 estimate from GWTC-1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of H0=68−6+8kms−1Mpc−1 with the galaxy catalog method, an improvement of 42% with respect to our GWTC-1 result and 20% with respect to recent H0 studies using GWTC-2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0) is the well-localized event GW190814
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