1,498 research outputs found
The Accuracy and Utility of Using Administrative Healthcare Databases to Identify People with Epilepsy: A Protocol for a Systematic Review and Meta-Analysis
The accuracy of using administrative healthcare data to identify epilepsy cases: A systematic review of validation studies
Using Critical Success Index or Gilbert Skill score as composite measures of positive predictive value and sensitivity in diagnostic accuracy studies: weather forecasting informing epilepsy research
Characteristics of NPS use in patients admitted to acute psychiatric services in Southeast Scotland:a retrospective cross-sectional analysis following public health interventions
Objectives: Assess the impact of selective prohibition and seizure of NPS supply on NPS use prevalence within psychiatric admissions and evaluate demographic characteristics of current NPS users. Design: A 6-month retrospective cross-sectional analysis of discharge letters between 1st October 2015 â 31st March 2016. Setting: General Psychiatry inpatients and Intensive Home Treatment Team community patients at a psychiatric hospital in a Scottish city. Participants: All participants were between the ages 18-65. After application of exclusion criteria, 473 discharge letters of General Psychiatry patients were deemed suitable for analysis and 264 Intensive Home Treatment Team (IHTT) patient discharge letters were analysed. Interventions: A nationwide Temporary Class Drug Order (TCDO) was placed on 10th April 2015 reclassifying methylphenidate-related compounds as Class B substances. On 15th October 2015, local Forfeiture Orders were granted to Trading Standards permitting the seizure of NPS supplies. Primary and secondary outcome measures: The primary outcome measure was to determine the prevalence of NPS use in two cohorts. Secondly, demographic features of patients and details regarding their psychiatric presentation were analysed. Results: The prevalence of NPS use in General Psychiatry and IHTT patients was 6.6% and 3.4%, respectively. Inpatients using NPS compared to non-users were more likely to be male (OR: 2.92, 95% CI: 1.28-6.66, p=0.009), have a forensic history (OR: 5.03, CI: 2.39-10.59, p<0.001) and be detained under an Emergency Detention Certificate (OR: 3.50, CI: 1.56-7.82, p=0.004). NPS users were also more likely to be diagnosed under ICD-10 F10-19 (OR: 9.97, CI: 4.62-21.49, p<0.001). Conclusions: Compared to previous work, psychiatric inpatient NPS use has fallen. NPS continue to be used by a demographic previously described resulting in presentations consistent with a drug-induced psychosis and at times requiring detention under the Mental Health Act. Further research is required to evaluate the effectiveness of the recent prohibition of all NPS
Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus.
Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. We compared the susceptibility of Aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. We found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosquitoes from an outbreak-prone region, particularly with respect to one dengue strain. These findings suggest recent evolution of population-based differences in vector competence or different historical origins. Future genomic comparisons of these populations could reveal the genetic basis of vector competence and the relative role of selection and stochastic processes in shaping their differences. Lastly, we show the novel finding of a correlation between midgut dengue titer and titer in tissues colonized after dissemination
Centrality dependence of pi^[+/-], K^[+/-], p and p-bar production from sqrt(s_NN)=130 GeV Au + Au collisions at RHIC
Identified pi^[+/-] K^[+/-], p and p-bar transverse momentum spectra at
mid-rapidity in sqrt(s_NN)=130 GeV Au-Au collisions were measured by the PHENIX
experiment at RHIC as a function of collision centrality. Average transverse
momenta increase with the number of participating nucleons in a similar way for
all particle species. The multiplicity densities scale faster than the number
of participating nucleons. Kaon and nucleon yields per participant increase
faster than the pion yields. In central collisions at high transverse momenta
(p_T greater than 2 GeV/c), anti-proton and proton yields are comparable to the
pion yields.Comment: 6 pages, 3 figures, 1 table, 307 authors, accepted by Phys. Rev.
Lett. on 9 April 2002. This version has minor changes made in response to
referee Comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
Event-by-event fluctuations in Mean and Mean in sqrt(s_NN) = 130 GeV Au+Au Collisions
Distributions of event-by-event fluctuations of the mean transverse momentum
and mean transverse energy near mid-rapidity have been measured in Au+Au
collisions at sqrt(s_NN) = 130 GeV at RHIC. By comparing the distributions to
what is expected for statistically independent particle emission, the magnitude
of non-statistical fluctuations in mean transverse momentum is determined to be
consistent with zero. Also, no significant non-random fluctuations in mean
transverse energy are observed. By constructing a fluctuation model with two
event classes that preserve the mean and variance of the semi-inclusive p_T or
e_T spectra, we exclude a region of fluctuations in sqrt(s_NN) = 130 GeV Au+Au
collisions.Comment: 10 pages, RevTeX 3, 7 figures, 4 tables, 307 authors, submitted to
Phys. Rev. C on 22 March 2002. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (will be made)
publicly available at
http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
Net Charge Fluctuations in Au + Au Interactions at sqrt(s_NN) = 130 GeV
Data from Au + Au interactions at sqrt(s_NN) = 130 GeV, obtained with the
PHENIX detector at RHIC, are used to investigate local net charge fluctuations
among particles produced near mid-rapidity. According to recent suggestions,
such fluctuations may carry information from the Quark Gluon Plasma. This
analysis shows that the fluctuations are dominated by a stochastic distribution
of particles, but are also sensitive to other effects, like global charge
conservation and resonance decays.Comment: 6 pages, RevTeX 3, 3 figures, 307 authors, submitted to Phys. Rev.
Lett. on 21 March, 2002. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (will be made) publicly
available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
Flow Measurements via Two-particle Azimuthal Correlations in Au + Au Collisions at sqrt(s_NN) = 130 GeV
Two particle azimuthal correlation functions are presented for charged
hadrons produced in Au + Au collisions at RHIC sqrt(s_NN) = 130 GeV. The
measurements permit determination of elliptic flow without event-by-event
estimation of the reaction plane. The extracted elliptic flow values v_2 show
significant sensitivity to both the collision centrality and the transverse
momenta of emitted hadrons, suggesting rapid thermalization and relatively
strong velocity fields. When scaled by the eccentricity of the collision zone,
epsilon, the scaled elliptic flow shows little or no dependence on centrality
for charged hadrons with relatively low p_T. A breakdown of this epsilon
scaling is observed for charged hadrons with p_T > 1.0 GeV/c for the most
central collisions.Comment: 6 pages, RevTeX 3, 4 figures, 307 authors, submitted to Phys. Rev.
Lett. on 11 April 2002. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (will be made) publicly
available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
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