A Very Low Resource Language Speech Corpus for Computational Language Documentation Experiments

Most speech and language technologies are trained with massive amounts of speech and text information. However, most of the world languages do not have such resources or stable orthography. Systems constructed under these almost zero resource conditions are not only promising for speech technology but also for computational language documentation. The goal of computational language documentation is to help field linguists to (semi-)automatically analyze and annotate audio recordings of endangered and unwritten languages. Example tasks are automatic phoneme discovery or lexicon discovery from the speech signal. This paper presents a speech corpus collected during a realistic language documentation process. It is made up of 5k speech utterances in Mboshi (Bantu C25) aligned to French text translations. Speech transcriptions are also made available: they correspond to a non-standard graphemic form close to the language phonology. We present how the data was collected, cleaned and processed and we illustrate its use through a zero-resource task: spoken term discovery. The dataset is made available to the community for reproducible computational language documentation experiments and their evaluation.Comment: accepted to LREC 201

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes

Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors. We previously demonstrated that in Drosophila the deficiency of Pyridoxal 5' phosphate (PLP), the active form of vitamin B6, causes chromosome aberrations (CABs), one of cancer prerequisites, and increases hemolymph glucose content. Starting from these data we asked if it was possible to provide a link between the aforementioned studies. Thus, we tested the effect of low PLP levels on DNA integrity in diabetic cells. To this aim we generated two Drosophila models of type 2 diabetes, the first by impairing insulin signaling and the second by rearing flies in high sugar diet. We showed that glucose treatment induced CABs in diabetic individuals but not in controls. More interestingly, PLP deficiency caused high frequencies of CABs in both diabetic models demonstrating that hyperglycemia, combined to reduced PLP level, impairs DNA integrity. PLP-depleted diabetic cells accumulated Advanced Glycation End products (AGEs) that largely contribute to CABs as α-lipoic acid, an AGE inhibitor, rescued not only AGEs but also CABs. These data, extrapolated to humans, indicate that low PLP levels, impacting on DNA integrity, may be considered one of the possible links between diabetes and cancer

Developing a new innovative methodology to integrate geophysical techniques into characterization of potential CO2 storage sites: Lopín structure (Southern Ebro basin, Spain)

Abstract:One of the main challenges facing geological storage is to identify cost-effective methodologicalworkflows for characterizing and monitoring geological storage sites. In the framework of the ALGECO2 pro-ject, led by the IGME (Geological and Mining Institute, Spain), a preliminary study of the Lopín site in the NEof Spain indicated conditions were promising for geological storage of CO2. However, the poor quality of thelegacy seismic reflection data precluded thorough characterization. Within the H2020 PilotSTRATEGY pro-ject, one of the possible selected target reservoirs was the Lopín structure. In order to characterize its geometryand physical properties as required to properly evaluate its storage potential, IGME applied a new emergingmethodology that integrates reinterpreted reflection seismic data with newly acquired and interpreted gravity,passive seismic and petrophysical data. This methodology was successfully applied along one seismic profile. Inthis paper, we present the results of this integration as thefirst step towards characterizing the site and evaluatingits suitability for storage.Funding for this research came from the Horizon 2020 Framework Programme (European Climate,Infrastructure and Environment Executive Agency (CINEA), award 101022664

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells

Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. This regulation was also observed in MDA-MB-231 human breast cancer cells, suggesting it is a conserved phenomenon in humans. Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. FAK is widely considered as a therapeutic target in cancer biology; however, it also has tumour suppressor properties in some contexts. Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours

A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth

The secreted morphogen Wingless promotes Drosophila wing growth by fueling a wave front of Fat-Dachsous signaling that recruits new cells into the wing primordium

Uif, a Large Transmembrane Protein with EGF-Like Repeats, Can Antagonize Notch Signaling in Drosophila

<div><h3>Background</h3><p>Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both spatially and temporally. The diversity, specificity and sensitivity of the Notch signaling output are regulated at distinct levels, particularly at the level of ligand-receptor interactions.</p> <h3>Methodology/Principal Findings</h3><p>Here, we report that the <em>Drosophila</em> gene <em>uninflatable</em> (<em>uif</em>), which encodes a large transmembrane protein with eighteen EGF-like repeats in its extracellular domain, can antagonize the canonical Notch signaling pathway. Overexpression of Uif or ectopic expression of a neomorphic form of Uif, Uif*, causes Notch signaling defects in both the wing and the sensory organ precursors. Further experiments suggest that ectopic expression of Uif* inhibits Notch signaling <em>in cis</em> and acts at a step that is dependent on the extracellular domain of Notch. Our results suggest that Uif can alter the accessibility of the Notch extracellular domain to its ligands during Notch activation.</p> <h3>Conclusions/Significance</h3><p>Our study shows that Uif can modulate Notch activity, illustrating the importance of a delicate regulation of this signaling pathway for normal patterning.</p> </div

Efficient distributed tag-based encryption and its application to group signatures with efficient distributed traceability

In this work, we first formalize the notion of dynamic group signatures with distributed traceability, where the capability to trace signatures is distributed among n managers without requiring any interaction. This ensures that only the participation of all tracing managers permits tracing a signature, which reduces the trust placed in a single tracing manager. The threshold variant follows easily from our definitions and constructions. Our model offers strong security requirements. Our second contribution is a generic construction for the notion which has a concurrent join protocol, meets strong security requirements, and offers efficient traceability, i.e. without requiring tracing managers to produce expensive zero-knowledge proofs for tracing correctness. To dispense with the expensive zero-knowledge proofs required in the tracing, we deploy a distributed tag-based encryption with public verifiability. Finally, we provide some concrete instantiations, which, to the best of our knowledge, are the first efficient provably secure realizations in the standard model simultaneously offering all the aforementioned properties. To realize our constructions efficiently, we construct an efficient distributed (and threshold) tag-based encryption scheme that works in the efficient Type-III asymmetric bilinear groups. Our distributed tag-based encryption scheme yields short ciphertexts (only 1280 bits at 128-bit security), and is secure under an existing variant of the standard decisional linear assumption. Our tag-based encryption scheme is of independent interest and is useful for many applications beyond the scope of this paper. As a special case of our distributed tag-based encryption scheme, we get an efficient tag-based encryption scheme in Type-III asymmetric bilinear groups that is secure in the standard model