CMB photons shedding light on dark matter

The annihilation or decay of Dark Matter (DM) particles could affect the thermal history of the universe and leave an observable signature in Cosmic Microwave Background (CMB) anisotropies. We update constraints on the annihilation rate of DM particles in the smooth cosmological background, using WMAP7 and recent small-scale CMB data. With a systematic analysis based on the Press-Schechter formalism, we also show that DM annihilation in halos at small redshift may explain entirely the reionization patterns observed in the CMB, under reasonable assumptions concerning the concentration and formation redshift of halos. We find that a mixed reionization model based on DM annihilation in halos as well as star formation at a redshift z~6.5 could simultaneously account for CMB observations and satisfy constraints inferred from the Gunn-Peterson effect. However, these models tend to reheat the inter-galactic medium (IGM) well above observational bounds: by including a realistic prior on the IGM temperature at low redshift, we find stronger cosmological bounds on the annihilation cross-section than with the CMB alone.Comment: 35 pages, 14 figures; version accepted in JCAP after minor revision

Faint recombination lines in Galactic PNe with [WC] nucleus

We present spatially resolved high-resolution spectrophotometric data for the planetary nebulae PB8, NGC2867, and PB6. We have analyzed two knots in NGC2867 and PB6 and one in PB8. The three nebulae are ionized by [WC] type nuclei: early [WO] for PB6 and NGC2867 and [WC 5-6] in the case of PB8. Our aim is to study the behavior of the abundance discrepancy problem (ADF) in this type of PNe. We measured a large number of optical recombination (ORL) and collisionally excited lines (CEL), from different ionization stages (many more than in any previous work), thus, we were able to derive physical conditions from many different diagnostic procedures. We determined ionic abundances from the available collisionally excited lines and recombination lines. Based on both sets of ionic abundances, we derived total chemical abundances in the nebulae using suitable ionization correction factors. From CELs, we have found abundances typical of Galactic disk planetary nebulae. Moderate ADF(O++) were found for PB8 (2.57) and NGC2867 (1.63). For NGC2867, abundances from ORLs are higher but still consistent with Galactic disk planetary nebulae. On the contrary, PB8 presents a very high O/H ratio from ORLs. A high C/O was obtained from ORLs for NGC2867; this ratio is similar to C/O obtained from CELs and with the chemical composition of the wind of the central star, indicating that there was no further C-enrichment in the star, relative to O, after the nebular material ejection. On the contrary, we found C/O<1 in PB8. Interestingly, we obtain (C/O)ORLs/(C/O)CELs < 1 in PB8 and NGC2867; this added to the similarity between the heliocentric velocities measured in [OIII] and OII lines for our three objects, argue against the presence of H-deficient metal-rich knots coming from a late thermal pulse event.Comment: 25 pages, 13 Tables, 4 Figures Accepted for publication in A&A. First page is blank for obscure latex reason

The 44Ti-powered spectrum of SN 1987A

SN 1987A provides a unique opportunity to study the evolution of a supernova from explosion into very late phases. Due to the rich chemical structure, the multitude of physical process involved, and extensive radiative transfer effects, detailed modeling is needed to interpret the emission from this and other supernovae. In this paper, we analyze the late-time (~8 years) HST spectrum of the SN 1987A ejecta, where 44Ti is the dominant power source. Based on an explosion model for a 19 Msun progenitor, we compute a model spectrum by calculating the degradation of positrons and gamma-rays from the radioactive decays, solving the equations governing temperature, ionization balance and NLTE level populations, and treating the radiative transfer with a Monte Carlo technique. We obtain a UV/optical/NIR model spectrum which is found to reproduce most of the lines in the observed spectrum to good accuracy. We find non-local radiative transfer in atomic lines to be an important process also at this late stage of the supernova, with ~30% of the emergent flux in the optical and NIR coming from scattering/fluorescence. We investigate the question of where the positrons deposit their energy, and favor the scenario where they are locally trapped in the Fe/He clumps by a magnetic field. Energy deposition into these largely neutral Fe/He clumps makes Fe I lines prominent in the emergent spectrum. Using the best available estimates for the dust extinction, we determine the amount of 44Ti produced in the explosion to 1.5\pm0.5 * 10^-4 Msun.Comment: 23 pages, 9 figures. 44Ti mass updated from 1.4E-4 to 1.5E-4 Msu

Deep Echelle Spectrophotometry of S 311, a galactic H II Region Outside the Solar Circle

We present echelle spectrophotometry of the Galactic H II region S 311. The data have been taken with the Very Large Telescope UVES echelle spectrograph in the 3100 to 10400 angstroms range. We have measured the intensities of 263 emission lines, 178 are permitted lines of H0, D0 (deuterium), He0, C0, C+, N0, N+, O0, O+, S+, Si0, Si+, Ar0 and Fe0; some of them are produced by recombination and others mainly by fluorescence. Physical conditions have been derived using different continuum and line intensity ratios. We have derived He+, C++ and O++ ionic abundances from pure recombination lines as well as abundances from collisionally excited lines for a large number of ions of different elements. We have obtained consistent estimations of t2 applying different methods. We have found that the temperature fluctuations paradigm is consistent with the t2(He I) vs. t2(H I) relation for H II regions, in contrast with what has been found for planetary nebulae. We report the detection of deuterium Balmer lines up to D6 in the blue wings of the hydrogen lines, which excitation mechanism seems to be continuum fluorescence.Comment: 13 pages, 12 tables, 5 figures, accepted for publication in MNRA

M1-78: a nitrogen-rich Galactic compact HII region beyond the Perseus arm

There is considerable controversy surrounding the nature of M1-78, a compact nebula located beyond the Perseus arm. It was first classified as a planetary nebula and is nowadays generally considered to be a compact HII region. To investigate the nature M1-78 further, we present a detailed spectroscopic study of M1-78 in the optical and near-infrared. M1-78 is a high-density nebula with substantial physical differences between its two main morphological zones: a bright arc to the SW and a blob of emission in the NE. Specifically, the blob in the NE has a higher electron temperature and visual extinction than the SW arc. The most important result, however, is the confirmation of a nitrogen enrichment in M1-78. This enrichment is stronger at the location of the NE blob and is correlated with a defficiency in the O abundance and a (dubious) He enrichment. Such an abundance pattern is typical of ejecta nebulae around evolved massive stars such as Wolf-Rayet and Luminous Blue Variable stars. The spatial variations in the physical conditions and chemical abundances and the presence of more than one possible ionizing source indicates, however, that M1-78 is better described as a combination of a compact HII region + ejecta. Finally, we detect H2 emission that extends over a large (~30 arcsec) area around the ionized nebula. Analysis of the near-infrared H2 lines indicates that the excitation mechanism is UV fluorescence.Comment: 14 pages, 8 figures. Accepted for publication in A&

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

<p>Abstract</p> <p>Background</p> <p>RRM1 and ERCC1 overexpression has been extensively investigated as potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most thoroughly in lung cancer. However, data in pancreatic cancer are scarce.</p> <p>Methods</p> <p>We investigated the mRNA and protein expression of ERCC1 and RRM1 by RT-PCR and immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded pancreatic ductal carcinoma (PDA) tissues. The primary outcome investigated was the association between RRM1 and ERCC1 expression and overall survival (OS) or disease-free survival (DFS).</p> <p>Results</p> <p>A total of 94 patients with resected PDA were included in this study. Most of them (87%) received gemcitabine based chemotherapy. Data for OS analysis was available in all cases but only 68% had enough information to estimate DFS. IHC analysis revealed information for 99% (93/94) and 100% of the cases for RRM1 and ERCC1 expression respectively. However, PCR data interpretation was possible in only 49 (52%) and 79 (84%) cases respectively. There was no significant association between high or low expression of either RRM1 or ERCC1, detected by IHC and OS (14.4 vs. 19.9 months; <it>P </it>= 0.5 and 17.1 vs. 19.9; <it>P </it>= 0.83 respectively) or PCR and OS (48.0 vs. 24.1 months; <it>P </it>= 0.21 and 22.0 vs. 16.0 months; <it>P </it>= 0.39 respectively). Similar results were obtained for DFS.</p> <p>Conclusions</p> <p>RRM1 and ERCC1 expression does not seem to have a clear predictive or prognostic value in pancreatic cancer. Our data raise some questions regarding the real clinical and practical significance of analyzing these molecules as predictors of outcomes.</p

Methylene Blue Reduces Fluid Loading and Norepinephrine Requirements for Post-Resuscitation Syndrome in a Pig Model of Refractory Cardiac Arrest Resuscitated with Veno-Arterial ECMO

Background: Refractory cardiac arrest management relies on extracorporeal cardiopulmonary resuscitation (ECPR), requiring the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Circulatory flow recovery can be associated with an ischemia&ndash;reperfusion injury, leading to vasoplegia and vasopressor requirement. The aim of this work was to evaluate the impact on hemodynamics of a methylene blue bolus infusion in a porcine model of ischemic refractory cardiac arrest. Methods: Ischemic refractory cardiac arrest was induced in 20 pigs. After a low flow period of 30 min, VA-ECMO was initiated and the pigs were randomly assigned to the standard care group (norepinephrine + crystalloids) or methylene blue group (IV 2 mg&middot;kg&minus;1 bolus of methylene blue over 30 min + norepinephrine and crystalloids). Macrocirculatory parameters and lactate clearance were measured. Sublingual microcirculation was evaluated with sidestream dark field (SDF) imaging. The severity of the ischemic digestive lesions was assessed according to the histologic Chiu/Park scale. Results: Eighteen pigs were included. The total crystalloid load (5000 (6000&ndash;8000) mL vs. 17,000 (10,000&ndash;19,000) mL, p = 0.007, methylene blue vs. standard care group) and catecholamine requirements (0.31 (0.14&ndash;0.44) &mu;g&middot;kg&minus;1&middot;min&minus;1 vs. 2.32 (1.17&ndash;5.55) &mu;g&middot;kg&minus;1&middot;min&minus;1, methylene blue vs. standard care group, p = 0.004) were significantly reduced in the methylene blue group. There were no significant between-group differences in lactate clearance, sublingual capillary microvascular parameters assessed by SDF or histologic Chiu/Park scale. Conclusions: In our refractory cardiac arrest porcine model treated with ECPR, methylene blue markedly reduced fluid loading and norepinephrine requirements in comparison to standard care during the first 6 h of VA-ECMO

Beta-blockers in septic shock: What is new?

The use of beta(β)-blockers during septic shock aimed at countering peripheral adrenergic stress may be justified by the early reduction in deleterious effects resulting from sympathetic overactivation, and could improve the prognosis of patients in septic shock. Animal studies have demonstrated either a maintenance or increase in cardiac output (CO) despite the decrease in heart rate (HR) associated with improved myocardial performance. The mechanism by which β-blockers alter hemodynamics in septic shock is debated; however, preclinical and clinical data show that β-blockers are safe when started at a low dose. Recent publications (2019–2021) on adrenergic β1 receptor antagonists used in septic shock indicate that esmolol and landiolol should not be used in the early phase. While there is no optimal timing for their administration, a minimum of 12 h after the initiation of vasopressor therapy in stabilized euvolemic patients is a reasonable option. Patients should have a normal cardiac function, although a slight depression is compatible with landiolol use under hemodynamic monitoring. Slow titration in patients who remain tachycardic is preferable to rapid titration. When used to decrease HR, landiolol is also effective in reducing the incidence of new arrhythmias. Results of a well-performed and well-powered randomized controlled trial (RCT) demonstrating a positive effect on survival – or at least on hard surrogates such as the incidence/duration of organ failure – are pending

Reports of puncture of the tracheal tube cuff during percutaneous dilatational tracheostomy procedures in the literature.

Reports of puncture of the tracheal tube cuff during percutaneous dilatational tracheostomy procedures in the literature.</p