Detection of Cocaine Use with Wireless Electrocardiogram Sensors

In recent years, the ability to continuously monitor activities, health, and lifestyles of individuals using sensor technologies has reached unprecedented levels. Such ubiquitous physiological sensing has the potential to profoundly improve our understanding of human behavior, leading to more targeted treatments for a variety of disorders. The long terms goal of this work is development of novel computational tools to support the study of addiction in the context of cocaine use. The current paper takes the first step in this important direction by posing a simple, but crucial question: Can cocaine use be reliably detected using wearable on-body sensors and current machine learning algorithms? We select wireless ECG as the most promising sensing modality for cocaine use detection. The main contributions in this paper include the presentation of a novel clinical study of cocaine use in which a unique set of wireless ECG data were collected, the description of a computational pipeline for inferring morphological features from noisy wireless ECG waveforms, and the evaluation of cocaine use detection algorithms based on data-driven and knowledge-based feature representations. Our results show that cocaine use can be detected with AUC levels above 0.9 in both the within-subjects and between-subjects cases at the 32mg/70kg dosage level

Efecto de la dieta sobre lípidos de la sangre y el hígado en ratas

Se presentan los resultados de un estudio de 100 días: el efecto de una dieta alta en colesterol, otra baja en proteínas y una dieta combinada (simultáneamente alta en colesterol y baja en proteína) sobre la colesterolemia y otros parámetros bioquímico

Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring

The purpose of this study is to contribute to a deeper understanding about how placement discontinuities of children in foster care affect their learning. The aim is to find out more about their learning and what role school plays in their life. A life-world perspective is used and theories mainly developed by Alfred Schütz (2002) build the theoretical framework. The empirical research is mainly based on narratives of a pair of twins at 19 years of age, who agreed to share their life stories and experiences of their time in school. Meetings were arranged separately with Alex, the boy, and Helena, the girl, both eager to participate. They felt that their stories could contribute to knowledge. The stories show that placement discontinuities in their early childhood made memories and their perspective of time blurry. They both suffered severe neglect in two of their foster care placements. School offered them a safe place throughout their adolescent years. However, despite this, they are critical to the teachers who saw that they suffered neglect at home but never acted upon that knowledge. Hence their first-hand experiences suggest that teachers, considered important in earlier research studies, are not as important as friend made or the daily routines that provide certain security in an otherwise uncertain life. The social services didn’t listen or support them. Alex and Helena felt that they had to take care of themselves. Their stories show that both of them are goal-oriented and that they highly value a good education. This is evident since they have always taken responsibility to complete set homework and to make school a functional place where they have also learned to know themselves. Furthermore, it is obvious that the twins have played a tremendous role for each other when their life-world time after time has changed. Alex and Helena’s stories and experiences can give the social services a deeper understanding of what lies behind the statistics. A teacher, who listens, shows support and has ambitious expectations regarding the children’s academic performance, has been confirmed in previous research to be of significant importance. In addition, the study shows that teachers should learn more about children in foster care. A life-world perspective and life-world theories can contribute to an alternative point of view regarding learning in life-world discontinuities. Learning can be reflected on by using Schütz theory about “strangers” as a way of understanding learning in a wider range, especially when there are discontinues in the life-world. The reflections made in this study point out the possibility that schools, as organizations, seem to have independent cultures that can be transferred between one another. In fact there seems to be certain variables that are the same for schools in general and hence it is of significant value to recognize school as a regional life-world. The expectations of how you act as a student and among friends are important for the sense of belonging. It is possible that Alex and Helena succeeded in school partly because some of the things they learned about the first school could be transferred to their new school. The study contributes with two new concepts; “livsvärldsbrott”- life-world-disruption and “livsvärldsbevarande”- life-world-preservation

Configuración de Linux NethServer y su uso para la administración de servicios de IT en una organización

El presente artículo desarrolla la instalación, configuración y puesta en marcha de un servidor «NethServer» en su versión 7.9, emulando una red empresarial, donde se consideran las zonas roja, naranja y verde que son conocidas como la zona de internet, zona desmilitarizada y zona local respectivamente. Se instalarán y se pondrán en marcha módulos que provee NethServer para el uso de cortafuegos, DHCP, DNS, Proxys, Firewalls entre otros. El artículo se divide en las temáticas, en donde cada una abordará la configuración y puesta en marcha de cada servicio.This article develops the installation, configuration and start-up of a "NethServer" server in its version 7.9, emulating an enterprise network, where the red, orange and green zones are considered, which are known as the internet zone, demilitarized zone and local zone respectively. Modules provided by NethServer for the use of firewalls, DHCP, DNS, Proxies, Firewalls among others will be installed and implemented. The article is divided into topics, where each one will address the configuration and implementation of each service

Efecto de la dieta sobre lípidos de la sangre y el hígado en ratas

Se presentan los resultados de un estudio de 100 días: el efecto de una dieta alta en colesterol, otra baja en proteínas y una dieta combinada (simultáneamente alta en colesterol y baja en proteína) sobre la colesterolemia y otros parámetros bioquímico

Detecting Cocaine Use with Wearable Electrocardiogram Sensors

Ubiquitous physiological sensing has the potential to profoundly improve our understanding of human behavior, leading to more targeted treatments for a variety of disorders. The long term goal of this work is development of novel computational tools to support the study of addiction in the context of cocaine use. The current paper takes the first step in this important direction by posing a simple, but crucial question: Can cocaine use be reliably detected using wearable electrocardiogram (ECG) sensors? The main contributions in this paper include the presentation of a novel clinical study of cocaine use, the development of a computational pipeline for inferring morphological features from noisy ECG waveforms, and the evaluation of feature sets for cocaine use detection. Our results show that 32mg/70kg doses of cocaine can be detected with the area under the receiver operating characteristic curve levels above 0.9 both within and between-subjects

Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring

Abstract Autism spectrum disorder (ASD) and intellectual disability (ID) can be caused by mutations in a large number of genes. One example is SHANK3 on the terminal end of chromosome 22q. Loss of one functional copy of SHANK3 results in 22q13 deletion syndrome or Phelan-McDermid syndrome (PMS) and causes a monogenic form of ASD and/or ID with a frequency of 0.5% to 2% of cases. SHANK3 is the critical gene in this syndrome, and its loss results in disruption of synaptic function. With chromosomal microarray analyses now a standard of care in the assessment of ASD and developmental delay, and with the emergence of whole exome and whole genome sequencing in this context, identification of PMS in routine clinical settings will increase significantly. However, PMS remains a rare disorder, and the majority of physicians have never seen a case. While there is agreement about core deficits of PMS, there have been no established parameters to guide evaluation and medical monitoring of the syndrome. Evaluations must include a thorough history and physical and dysmorphology examination. Neurological deficits, including the presence of seizures and structural brain abnormalities should be assessed as well as motor deficits. Endocrine, renal, cardiac, and gastrointestinal problems all require assessment and monitoring in addition to the risk of recurring infections, dental and vision problems, and lymphedema. Finally, all patients should have cognitive, behavioral, and ASD evaluations. The objective of this paper is to address this gap in the literature and establish recommendations to assess the medical, genetic, and neurological features of PMS