New insights into structural determinants of prion protein folding and stability

Prions are the etiological agent of fatal neurodegenerative diseases called prion diseases or transmissible spongiform encephalopathies. These maladies can be sporadic, genetic or infectious disorders. Prions are due to post-translational modifications of the cellular prion protein leading to the formation of a \u3b2-sheet enriched conformer with altered biochemical properties. The molecular events causing prion formation in sporadic prion diseases are still elusive. Recently, we published a research elucidating the contribution of major structural determinants and environmental factors in prion protein folding and stability. Our study highlighted the crucial role of octarepeats in stabilizing prion protein; the presence of a highly enthalpically stable intermediate state in prion-susceptible species; and the role of disulfide bridge in preserving native fold thus avoiding the misfolding to a \u3b2-sheet enriched isoform. Taking advantage from these findings, in this work we present new insights into structural determinants of prion protein folding and stability

Supernova search at intermediate z. I. Spectroscopic analysis

We study 8 supernovae discovered as part of the International Time Programme (ITP) project ``Omega and Lambda from Supernovae and the Physics of Supernova Explosions'' at the European Northern Observatory (ENO). The goal of the project is to increase the sample of intermediate redshift (0.1<z<0.4) SNe Ia for testing properties of SNe Ia along z and for enlarging the sample in the Hubble diagram up to large z.Comment: 2 pages, 2 figures, 1 table, to appear in ``1604-2004: Supernovae as Cosmological Lighthouses'', (extended text upon request

SN 2013df, a double-peaked IIb supernova from a compact progenitor and an extended H envelope

Optical observations of the type IIb SN 2013df from a few days to about 250 days after explosion are presented. These observations are complemented with UV photometry taken by \textit{SWIFT} up to 60 days post-explosion. The double-peak optical light curve is similar to those of SNe 1993J and 2011fu although with different decline and rise rates. From the modelling of the bolometric light curve, we have estimated that the total mass of synthesised $^{56}$Ni in the explosion is $\sim0.1$ M$_{\odot}$, while the ejecta mass is $0.8-1.4$ M$_{\odot}$ and the explosion energy $0.4-1.2 \times 10^{51}$erg. In addition, we have estimated a lower limit to the progenitor radius ranging from $64-169$ $R_{\odot}$. The spectral evolution indicates that SN 2013df had a hydrogen envelope similar to SN 1993J ($\sim 0.2$ M$_{\odot}$). The line profiles in nebular spectra suggest that the explosion was asymmetric with the presence of clumps in the ejecta, while the [O\,{\sc i}] $\lambda$$\lambda$$6300$, $6364$ luminosities, may indicate that the progenitor of SN 2013df was a relatively low mass star ( $\sim 12-13$ M$_{\odot}$).Comment: 18 pages, 11 figures, 9 tables, accepted for publication in MNRA

Meeting report: Sixth International Symposium on Resonance Ionization Spectroscopy and its Applications

In this paper, an attempt will be made to give an overview of the scientific contents of the meeting. Since it would be impossible to cover exhaustively all the topics presented, we have tried to emphasize some applications, with special emphasis to the analytical aspects of the presentation. The Sixth International Symposium on Resonance Ionization Spectroscopy and its Applications (RIS-92) was held in Santa Fe, New Mexico, USA, from May 24 to 29, 1992

The spectacular evolution of Supernova 1996al over 15 years: a low energy explosion of a stripped massive star in a highly structured environment

Spectrophotometry of SN 1996al carried out throughout 15 years is presented. The early photometry suggests that SN 1996al is a Linear type-II supernova, with an absolute peak of Mv ~ -18.2 mag. Early spectra present broad, asymmetric Balmer emissions, with super-imposed narrow lines with P-Cygni profile, and He I features with asymmetric, broad emission components. The analysis of the line profiles shows that the H and He broad components form in the same region of the ejecta. By day +142, the Halpha profile dramatically changes: the narrow P-Cygni profile disappears, and the Halpha is fitted by three emission components, that will be detected over the remaining 15 yrs of the SN monitoring campaign. Instead, the He I emissions become progressively narrower and symmetric. A sudden increase in flux of all He I lines is observed between 300 and 600 days. Models show that the supernova luminosity is sustained by the interaction of low mass (~1.15 Msun) ejecta, expelled in a low kinetic energy (~ 1.6 x 10^50 erg) explosion, with highly asymmetric circumstellar medium. The detection of Halpha emission in pre-explosion archive images suggests that the progenitor was most likely a massive star (~25 Msun ZAMS) that had lost a large fraction of its hydrogen envelope before explosion, and was hence embedded in a H-rich cocoon. The low-mass ejecta and modest kinetic energy of the explosion are explained with massive fallback of material into the compact remnant, a 7-8 Msun black hole.Comment: 27 pages, 23 figures, Accepted for publication in MNRA

The Type IIn Supernova SN 2010bt: The Explosion of a Star in Outburst

Indexación: Scopus.It is well known that massive stars (M > 8 M ) evolve up to the collapse of the stellar core, resulting in most cases in a supernova (SN) explosion. Their heterogeneity is related mainly to different configurations of the progenitor star at the moment of the explosion and to their immediate environments. We present photometry and spectroscopy of SN 2010bt, which was classified as a Type IIn SN from a spectrum obtained soon after discovery and was observed extensively for about 2 months. After the seasonal interruption owing to its proximity to the Sun, the SN was below the detection threshold, indicative of a rapid luminosity decline. We can identify the likely progenitor with a very luminous star (log L/L ≈ 7) through comparison of Hubble Space Telescope images of the host galaxy prior to explosion with those of the SN obtained after maximum light. Such a luminosity is not expected for a quiescent star, but rather for a massive star in an active phase. This progenitor candidate was later confirmed via images taken in 2015 (∼5 yr post-discovery), in which no bright point source was detected at the SN position. Given these results and the SN behavior, we conclude that SN 2010bt was likely a Type IIn SN and that its progenitor was a massive star that experienced an outburst shortly before the final explosion, leading to a dense H-rich circumstellar environment around the SN progenitor. © 2018. The American Astronomical Society. All rights reserved.https://iopscience.iop.org/article/10.3847/1538-4357/aac51