Effect of Omega-3 Fatty Acids on Lipoprotein Profile and Particle Size in Hispanic Women

The effect of increased Ω3 fatty acids on lipoprotein sub-fractions has not been well studied in Hispanic women, a group with a high prevalence of dyslipidemia and metabolic syndrome. The purpose of this randomized, placebo-controlled trial was to examine the effect of a 90-day (90D) combined EPA+DHA supplementation on lipoprotein profiles of Hispanic women. Twenty-seven non-diabetic women were randomly assigned to the Ω3 group (n=17, 1.9 g/day EPA+DHA) or the placebo group (n=10, 2 g/day oleic acid). At baseline (0D) and 90D a fasting blood sample was drawn for determination of lipoprotein profile and lipoprotein particle sub-fractions. For the Ω3 group, total cholesterol increased 6.5%, triglycerides were reduced 14.8%, LDL concentration increased 5.6%, and total LDL particle size concentration increased 8.2% (P \u3c 0.05). Large LDL particle size concentration increased 16% from 0D to 90D, this change was not significant (P = 0.051). At 90D, total cholesterol, LDLs, and LDL particle concentration were higher in the Ω3 group compared to placebo (P \u3c 0.05). Omega-3 supplementation resulted in reduced plasma TGs and an increase in large LDL particle size concentration, yet had no effect on HDL particle size or concentration. Further research is necessary to examine the effects of increased Ω3 fatty acid intake in Hispanic women on dyslipidemia and related co-morbidities

The association of being in quarantine and related COVID-19 recommended and non-recommended behaviors with psychological distress in Chinese population

Novel coronavirus SARS-CoV-2, the virus causing COVID-19, emerged in Wuhan China but rapidly spread to other regions in China. This led to the quarantine of Wuhan city, and the recommendation of a number of precautious behaviors by both the World Health organisation (WHO) and the Chinese centre for Disease control (CDC). Mortality salience increases distress (Greenberg et al., 1986), and previous studies reported increased psychological distress during the previous SARS-CoV coronavirus (Lee et al., 2007; Hawryluck et al., 2004). Anxiety can motivate people to adopt preventive measures during a pandemic (Leung et al., 2005). Drawing on health belief models (Weinstein and Nicolich, 1993), research conducted during H1N1 (‘swine flu’) and SARS-CoV positively associated distress with internationally recommended health behaviours (Leung et al., 2005). However, anxiety may also encourage non-recommended, avoidant behaviours (Rubin et al., 2009). To date no empirical study to date has examined associations between psychological distress, quarantine and the use of recommend and non-recommended behaviors. Understanding this may be crucial for comprehending the psychological drivers of important behaviors at a time of national crisis, as well as the avoidance of behaviors with negligible or negative impact on health outcomes

Quarantine, distress and interpersonal relationships during COVID-19

Novel zoonosis COVID-19 first emerged in Wuhan, China, but rapidly spread to the other regions in China. The spread of this severe acute respiratory syndrome led to the quarantine of 60 million Chinese citizens. Such isolation measures have been associated with increased depression, stress and emotional disturbance.1–3 However, major traumatic events can amplify both positive and negative aspects of interpersonal relations, leading to competing narratives of both harm and enhancement.4 5 Quarantine can create family dependencies, threaten livelihoods and lead to the stigmatisation of those infected.3 6 School closures and disruption of family care seriously disrupt regular domestic practices.2 7 Domestic abuse may burgeon in a situation of forced confinement.1 2 Community relations may become strained as individuals fear infection from others. Anxiety may quickly spread through social networks via a process of ‘emotional contagion’ in which people ‘catch’ the worry of others.8 At the same time, however, large-scale containment may promote common solidarities.3 6 Romantic relationships can provide a sense of security during a time of existential concern.9 New liaisons may arise within and across communities, with community-level support associated with lower levels of distress.10 At present, it is unclear the extent to which relationship enhancement or decline will apply across different forms of relationships. In this forum, we report early work where we explore the associations between quarantine and reported changes across a range of relationships while controlling for psychological distress

Lymphoid aggregates in the bone marrow biopsies of patients with myelodysplastic syndromes – A potential prognostic marker?

BackgroundLymphoid aggregates (LA) are occasionally seen in bone marrow biopsies (BMB) of myelodysplastic syndromes (MDS) patients. Our aim was to evaluate their incidence and association with prognosis.MethodsWe compared BMB reports of MDS patients treated at the Tel Aviv Sourasky Medical Center (2011-2018), and controls (2015-2017, normal BMB), and examined the charts of the MDS patients (LA+ and LA-). Categorical, normally and non-normally distributed continuous variables were compared using Fisher’s exact, independent t and Mann-Whitney tests respectively. Adjusted [age, gender, lymphocytes, white blood cells (WBC) and diabetes mellitus (DM)] Cox proportional hazard model examined survival at 12 and 24 months.ResultsMDS patients (N=140) were older than controls (N=38; 74.1 vs 69.2 years, p=0.005); 34 MDS (24.3%) and 5 controls (13.2%) had LA+ (P=0.141). CD20/CD3 staining suggested LA polyclonality. MDS/LA+ (vs MDS/LA-) patients were younger, with a trend (not statistically significant) towards poor prognostic parameters: lower Hb, WBC, and platelets, higher LDH, BM cellularity, and IPSS-R score. The incidence of cardiovascular disease was similar, but MDS/LA+ had twice the incidence of DM (38.2% vs 19.0%, p=0.022). Similar trend for cancer (26.5% vs 14.3%, p=0.102). Twelve-month survival: 24/34 (70.6%) MDS/LA+; 88/106 (83.0%) MDS/LA- (p=0.140). This trend, seen in Kaplan-Meier curves, disappeared at 24 months. The hazard ratio for LA was 2.283 (p=0.055) for 12 months.ConclusionThese preliminary data suggest LA are relatively common (24%) in MDS BMB, and might indicate poor prognosis. This may reflect involvement of the immune system in MDS. Future studies will examine larger groups, to clarify the incidence, significance and the pathophysiology

Jewish Studies in the Digital Age: Introduction

Introduction to the (open access) book Jewish Studies in the Digital Age (De Gruyter Oldenbourg, 2022). Abstract: As in all fields and disciplines of the humanities, Jewish Studies scholars find themselves confronted with the rapidly increasing availability of digital resources (data), new technologies to interrogate and analyze them (tools), and the question of how to critically engage with these developments. This volume discusses how the digital turn has affected the field of Jewish Studies. It explores the current state of the art and probes how digital developments can be harnessed to address the specific questions, challenges and problems that Jewish Studies scholars confront. In a field characterised by dispersed sources, and heterogeneous scripts and languages that speak to a multitude of cultures and histories, of abundance as well as loss, what is the promise of Digital Humanities methods--and what are the challenges and pitfalls? The articles in this volume were originally presented at the international conference #DHJewish - Jewish Studies in the Digital Age, which was organised at the Centre for Contemporary and Digital History (C²DH) at University of Luxembourg in January 2021. The first big international conference of its kind, it brought together more than sixty scholars and heritage practitioners to discuss how the digital turn affects the field of Jewish Studies

Vaccine hesitancy prospectively predicts nocebo side-effects following COVID-19 vaccination

The directionality between vaccine hesitancy and COVID-19 vaccine side-effects has not been hitherto examined. We hypothesized a nocebo effect, whereby vaccine hesitancy towards the second Pfizer vaccination dose predicts subsequent side-effects for a booster dose, beyond other effects. We expected these nocebo effects to be driven by (mis)information in males and prior experience in females. A representative sample of older adults (n = 756, mean age = 68.9 ± 3.43) were questioned in a typical cross-lagged design (wave 1 following a second Pfizer dose, wave 2 after their booster). As hypothesized, earlier vaccine hesitancy predicted subsequent booster side-effects for females (β = 0.10 p = 0.025, f 2 = 0.02) and males (β = 0.34, p < 0.001, f 2 = 0.16); effects were stronger in males (χ2Δ (1) = 4.34, p = 0.03). The (W1-to-W2) side-effect autoregression was stronger in females (β = .34, p < 0.001; males β = 0.18, p < 0.001), χ2Δ (1) = 26.86, p < 0.001. Results show that a quantifiable and meaningful portion of COVID-19 vaccine side-effects is predicted by vaccine hesitancy, demonstrating that side-effects comprise a psychosomatic nocebo component in vaccinated individuals. The data reveal distinct risk levels for future side-effects, suggesting the need to tailor public health messaging

Spatial-spectral flexible optical networking:enabling switching solutions for a simplified and efficient SDM network platform

The traffic carried by core optical networks grows at a steady but remarkable pace of 30-40% year-over-year. Optical transmissions and networking advancements continue to satisfy the traffic requirements by delivering the content over the network infrastructure in a cost and energy efficient manner. Such core optical networks serve the information traffic demands in a dynamic way, in response to requirements for shifting of traffics demands, both temporally (day/night) and spatially (business district/residential). However as we are approaching fundamental spectral efficiency limits of singlemode fibers, the scientific community is pursuing recently the development of an innovative, all-optical network architecture introducing the spatial degree of freedom when designing/operating future transport networks. Spacedivision- multiplexing through the use of bundled single mode fibers, and/or multi-core fibers and/or few-mode fibers can offer up to 100-fold capacity increase in future optical networks. The EU INSPACE project is working on the development of a complete spatial-spectral flexible optical networking solution, offering the network ultra-high capacity, flexibility and energy efficiency required to meet the challenges of delivering exponentially growing traffic demands in the internet over the next twenty years. In this paper we will present the motivation and main research activities of the INSPACE consortium towards the realization of the overall project solution