Spezifikation Niederdruckverdichter

Spezifikation eines Niederdruckverdichters: Vorgehen, Design, Anforderungen für Aerodynamik, Aeroelastik und Strukturbewertung, Fertigun

Abschlussbericht: Multidisziplinäres Kompressor Konzept (MuKoKo)

Abschlussbericht des Projektes Multidisziplinäres Kompressor Konzept (MuKoKo) Inhalt: Design und Auslegung eines zweieinhalbstufigen militärischen Niederdruckverdichters im Hinblick auf eine potentielle fliegende Anwendung Laufzeit: 07/2014 bis 04/2020 Version 1.2 vom 28.10.202

Lessons Learned aus dem Projekt Multidisziplinäres Kompressor Konzept (MuKoKo)

Zusammenfassung der Projekterkenntnisse bezüglich Kooperation, Leitung und fachlicher Themen aus den einzelnen beteiligten Disziplinen

Eye for I : Video Self-Portraits

Bellour ascribes three values (of truth, of the act and of identity) to video's potential for self-portraiture; the author delineates modes of time, place and imagery, as well as relationships to the body, to television and to the margins in his discussion of the work of the 14 artists in the exhibition. Each tape is briefly documented alongside a statement by the artist

Blood Pressure Loci Identified with a Gene-Centric Array

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 × 10−7 study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r2 = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10−7 at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies