Cyclops states in repulsive Kuramoto networks: the role of higher-order coupling

Repulsive oscillator networks can exhibit multiple cooperative rhythms, including chimera and cluster splay states. Yet, understanding which rhythm prevails remains challenging. Here, we address this fundamental question in the context of Kuramoto-Sakaguchi networks of identical rotators with higher-order coupling. Through analysis and numerics, we show that three-cluster splay states with two distinct coherent clusters and a solitary oscillator are the prevalent rhythms in networks with an odd number of units. We denote such tripod patterns cyclops states with the solitary oscillator reminiscent of the Cyclops's eye. As their mythological counterparts, the cyclops states are giants that dominate the system's phase space in weakly repulsive networks with first-order coupling. Astonishingly, the addition of the second or third harmonics to the Kuramoto coupling function makes the cyclops states global attractors practically across the full range of coupling's repulsion. At a more general level, our results suggest clues for finding dominant rhythms in repulsive physical and biological networks

Polymorphism of SERF2, the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke

Ischemic stroke (IS) is one of the most serious cardiovascular events associated with high risk of death or disability. The growing body of evidence highlights molecular chaperones as especially important players in the pathogenesis of the disease. Since six small proteins called “Hero” have been recently identified as a novel class of chaperones we aimed to evaluate whether SNP rs4644832 in SERF2 gene encoding the member of Hero-proteins, is associated with the risk of I

Определение сакситоксина в воде озера Байкал

Выполнено определение сакситоксина в пробах поверхностной воды, отобранной летом 2018 года в период массового цветения цианобактерий в прибрежной зоне заливов Ая, Тутай (западное побережье Байкала), Мухор (пролив Малое Море), Посольский сор и около села Турка (восточное побережье Байкала). Для определения сакситоксина использована методика определения, основанная на химической модификации сакситоксина 2,4-динитрофенилгидразином с последующей идентификацией гидразона сакситоксина методом жидкостной хроматографии с масс-спектрометрическим детектированием. Для проб с ожидаемой низкой концентрацией сакситоксина предложен усовершенствованный вариант методики. Показано, что содержание сакситоксина в воде во всех исследованных пробах ниже рекомендованной для питьевой воды (< 3 мкг/л)

Assessment of gastrointestinal dysfunction in selection of an effective method of nutritional support in patients with acute pancreatitis.

Potential mortality in acute pancreatitis (AP) is 5%. Patients with AP represent II type of intestinal insufficiency, which occurs on the background of dyspeptic syndrome and increased intra-abdominal pressure (IAP). IAP is a differentiated indicator. With the increase of IAP more than 10 mmHg, intra-abdominal hypertension (IAH) arises. Increasing IAP to this level is considered as safe. Monitoring of IAP level allows to achieve better clinical results. Totally 47 patients with acute pancreatitis were examined. Depending on the function of the gastrointestinal tract and the selected type of starting nutritional support (NS), they were divided into 2 groups. The first group consisted of IAH patients of I degree and dyspeptic syndrome who underwent parenteral nutrition (PN) with 3-component compounds begun on the 2nd day of disease and after restoration of gastrointestinal tract function a late enteral feeding (LEF) was performed. In the second group, patients with AP were initially diagnosed with elevated IAP at a safe level and dyspeptic syndrome. They were prescribed early enteral nutrition (EEN) with specialized blends from the 2nd day of disease. In 2 days a significant reduction in pain syndrome with the persistence of dyspeptic syndrome and intestinal insufficiency (II) was recorded. In patients with intra-abdominal hypertension, total parenteral nutrition is the effective method of nutritional support, against which, after 5 days manifestations of dyspeptic syndrome and IAP indices decrease to a safe level. Therefore in-time detection of high level of intra-abdominal pressure in patients with acute pancreatitis can help to choose a more rational method of nutritional support

Rapid ecological change in the coastal zone of Lake Baikal (East Siberia): Is the site of the world\u27s greatest freshwater biodiversity in danger?

Ecological degradation of the benthic littoral zone is an emerging, urgent problem at Lake Baikal (East Siberia), the most species-rich lake on Earth. Within the last five years, multiple changes have occurred in the nearshore benthos where most of the lake\u27s endemic species reside. These changes include proliferation of benthic algae, deaths of snails and endemic sponges, large coastal wash-ups of dead benthic algae and macrophytes, blooms of toxin-producing benthic cyanobacteria, and inputs of industrial contaminants into parts of the lake. Some changes, such as massive coastal accumulations of benthic algae, are currently shared with the Laurentian Great Lakes (LGLs); however, the drivers of these changes differ between Lake Baikal and the LGLs. Coastal eutrophication from inputs of untreated sewage is causing problems at multiple sites in Lake Baikal, whereas in the LGLs, invasive dreissenid mussels redirect pelagic nutrients to the littoral substrate. At other locations in Lake Baikal, ecological degradation may have different causes including water level fluctuations and the input of toxic industrial contaminants. Importantly, the recent deterioration of the benthic littoral zone in both Lake Baikal and the LGLs has occurred while little change has occurred offshore. This highlights the necessity of monitoring both the littoral and pelagic zones of large lakes for assessing ecosystem health, change and conservation

Influence of the topology on the dynamics of a complex network of HIV/AIDS epidemic models

In this paper, we propose an original complex network model for an epidemic problem in an heterogeneous geographical area. The complex network is constructed by coupling nonidentical instances of a HIV/AIDS epidemiological model for which a disease-free equilibrium and an endemic equilibrium can coexist. After proving the existence of a positively invariant region for the solutions of the complex network problem, we investigate the effect of the coupling on the dynamics of the network, and establish the existence of a unique disease-free equilibrium for the whole network, which is globally asymptotically stable. We prove the existence of an optimal topology that minimizes the level of infected individuals, and apply the theoretical results to the case of the Cape Verde archipelago.This research was partially supported by the Portuguese Foundation for Science and Technology (FCT) within projects UID/MAT/04106/2019 (CIDMA) and PTDC/EEI-AUT/2933/2014 (TOCCATTA), co-funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalizac¸ao (POCI) and by national funds (FCT). Silva is also supported by national funds (OE), through FCT, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19.publishe

SOSTOYaNIE KAL'TsIY-FOSFORNOGO OBMENA U BOL'NYKh SAKhARNYM DIABETOM 1 TIPA

Condition of bone tissue and calcium - phosphorus exchange in patients wish type 1 diabetes mellitus. Aim: the estimation the calcium - phosphorus exchange and calcium - regulation hormones of absolute insulin insufficient on base measuring. Materials and methods: were inspected 61 patients wish type 1 diabetes mellitus (age 20 - 50 years) and prolong of disease from 1 to 24 years. All patients got insulin in dose-depending regime. 38 patients were diagnostic decompensate type 1 diabetes mellitus, 18 - subcompensate diabetes mellitus and 5 patients had stage of compensation disease. Control group was consisted by 50 people. All patients were estimated calcium - phosphorus exchange and condition of calcium - regulation hormones. Results. It is marked the level of calcium (Ca) increase and increase secretion of parathyroid hormone (PTH) and calcitonine (CT) in depending of prolong and during type 1 diabetes mellitus. Increasing of urinasy exretion calcium and phosphor has positive correlation with the glycemia level in the blood in patients with type 1 diabetes mellitus. Conclusion. It was marked the calcium - phosphorus exchange and increase calcium - regulation hormones levels