Monitoring the electrochemical behavior of hybrid coatings on magneto-elastic sensors using resonant frequency variations

In this work we present results for the protective performance of coatings used on magneto-elastic ribbons. It is found that monitoring the resonance frequency variation (Δf) of a magneto-elastic sensor can give useful electrochemical information. This method has the advantage of allowing one to monitor the electrochemical behavior of coatings without the need for direct access to the sample. A sensor developed from the FeNiMoB alloy (Metglas 2826MB3) was covered with hybrid coatings based on silicon alkoxide precursors. The results obtained from the magneto-elastic sensor test were correlated with the results obtained from electrochemical impedance spectroscopy (EIS). In general, it was observed that the Δf monitoring technique provided results consistent with those obtained by EIS, with the advantage that it does not need to have direct contact with the sample. Besides that monitoring the resonance frequency also allows one to evaluate the electrochemical behavior of the coating in the medium of interest

Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors

Made available in DSpace on 2018-12-11T17:23:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01Context: Even though the majority of well-differentiated thyroid carcinoma (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 nonneoplastic thyroid tissues (NTs), 17 benign thyroid lesions (BTLs), and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated, and 3 anaplastic). A prognostic classifier for WDTC was developed via diagonal linear discriminant analysis. The results were compared with The Cancer Genome Atlas (TCGA) database. Results: A specific epigenetic profile was detected according to each histological subtype. BTLs and follicular carcinomas showed a greater number of methylated CpG in comparison with NTs, whereas hypomethylation was predominant in papillary and undifferentiated carcinomas. A prognostic classifier based on 21 DNA methylation probes was able to predict poor outcome in patients with WDTC (sensitivity 63%, specificity 92% for internal data; sensitivity 64%, specificity 88% for TCGA data). High-risk score based on the classifier was considered an independent factor of poor outcome (Cox regression, P < 0.001). Conclusions: The methylation profile of thyroid lesions exhibited a specific signature according to the histological subtype. A meaningful algorithm composed of 21 probes was capable of predicting the recurrence in WDTC.International Research Center, CIPE, A.C. Camargo Cancer Center and National Institute of Science and Technology in Oncogenomics, São Paulo 01509-010, SP, BrazilDepartment of Urology, Faculty of Medicine, UNESP, São Paulo State University, Botucatu 18618-970, SP, BrazilDepartment of Pathology, A.C. Camargo Cancer Center, São Paulo 01509-010, SP, BrazilEpigenetics Group; International Agency for Research on Cancer (IARC), Lyon 69372, FranceMRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 1TH, United KingdomDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo 01509-010, SP, BrazilDepartment of Clinical Genetics, Vejle Hospital and Institute of Regional Health Research, University of Southern Denmark, Vejle, 7100, Denmar

Evaluating Employee Satisfaction in a Production Firm

Import 04/11/2015Tématem mé bakalářské práce je hodnocení spokojenosti zaměstnanců ve výrobní firmě. Teoretická část je věnována pracovní spokojenost, dále pak pracovním podmínkám, komunikaci a systému odměňování. V praktické části bakalářské práce je vyhodnocení dotazníku z let 2011-2013.Topic of my thesis is to evaluate employee satisfaction in the company of production. The theoretical part is devoted to the job satisfaction, as well as working conditions, communications and remunerations system. In the practical part of the thesis is the evaluation of a questionnaire from the years 2011-2013.115 - Katedra managementudobř

Optimization Of the Weighted Multiple Points Source Model Utilizing the General Extremal Optimization (GEO) for Flames in an air Cross Flow

O presente trabalho estuda a aplicação e otimização de modelos simplificados de engenharia para prever o fluxo radiativo proveniente de chamas difusivas turbulentas sob o efeito de um escoamento de ar lateral. Para o estudo, é empregado uma base de dados experimentais, que considera chamas de gás natural com diversas potências e diluições de CO2. Foi implementado o modelo de única fonte pontual e múltiplas fontes ponderadas. Foi estabelecido um processo de otimização sobre o modelo de múltiplas fontes pontuais como um problema inverso. O método estocástico, Generalized Extremal Optimization, foi empregado para encontrar a melhor combinação das variáveis do problema. O resultado final gerou um polinômio de segundo grau para a definição dos fatores de ponderação para o conjunto das chamas estudadas.The present study implements engineering simplified methods to predict the radiant heat flux emitted by diffusive turbulent flames under the influence of an air crossflow. In this study, an experimental database is used which considers natural gas flames with various flame powers and CO2 dilution. The single point source model and weighted multiple point source model were implemented. An optimization process was established using the multiple point source as an inverse problem. The stochastic model, Generalized Extremal Optimization, was used to search the best combination of the problem variables. The final results created a second degree polynomial to distribute the weighted factors to the group of flames studied