Nonmonotonic Decay of Nonequilibrium Polariton Condensate in Direct-Gap Semiconductors

Time evolution of a nonequilibrium polariton condensate has been studied in the framework of a microscopic approach. It has been shown that due to polariton-polariton scattering a significant condensate depletion takes place in a comparatively short time interval. The condensate decay occurs in the form of multiple echo signals. Distribution-function dynamics of noncondensate polaritons have been investigated. It has been shown that at the initial stage of evolution the distribution function has the form of a bell. Then oscillations arise in the contour of the distribution function, which further transform into small chaotic ripples. The appearance of a short-wavelength wing of the distribution function has been demonstrated. We have pointed out the enhancement and then partial extinction of the sharp extra peak arising within the time interval characterized by small values of polariton condensate density and its relatively slow changes.Comment: 20 pages, LaTeX 2.09; in press in PR

Self-organization of developing embryo using scale-invariant approach

<p>Abstract</p> <p>Background</p> <p>Self-organization is a fundamental feature of living organisms at all hierarchical levels from molecule to organ. It has also been documented in developing embryos.</p> <p>Methods</p> <p>In this study, a scale-invariant power law (SIPL) method has been used to study self-organization in developing embryos. The SIPL coefficient was calculated using a centro-axial skew symmetrical matrix (CSSM) generated by entering the components of the Cartesian coordinates; for each component, one CSSM was generated. A basic square matrix (BSM) was constructed and the determinant was calculated in order to estimate the SIPL coefficient. This was applied to developing <it>C. elegans </it>during early stages of embryogenesis. The power law property of the method was evaluated using the straight line and Koch curve and the results were consistent with fractal dimensions (fd). Diffusion-limited aggregation (DLA) was used to validate the SIPL method.</p> <p>Results and conclusion</p> <p>The fractal dimensions of both the straight line and Koch curve showed consistency with the SIPL coefficients, which indicated the power law behavior of the SIPL method. The results showed that the ABp sublineage had a higher SIPL coefficient than EMS, indicating that ABp is more organized than EMS. The fd determined using DLA was higher in ABp than in EMS and its value was consistent with type 1 cluster formation, while that in EMS was consistent with type 2.</p

Reduced costs with bisoprolol treatment for heart failure - An economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II)

Background Beta-blockers, used as an adjunctive to diuretics, digoxin and angiotensin converting enzyme inhibitors, improve survival in chronic heart failure. We report a prospectively planned economic analysis of the cost of adjunctive beta-blocker therapy in the second Cardiac Insufficiency BIsoprolol Study (CIBIS II). Methods Resource utilization data (drug therapy, number of hospital admissions, length of hospital stay, ward type) were collected prospectively in all patients in CIBIS . These data were used to determine the additional direct costs incurred, and savings made, with bisoprolol therapy. As well as the cost of the drug, additional costs related to bisoprolol therapy were added to cover the supervision of treatment initiation and titration (four outpatient clinic/office visits). Per them (hospital bed day) costings were carried out for France, Germany and the U.K. Diagnosis related group costings were performed for France and the U.K. Our analyses took the perspective of a third party payer in France and Germany and the National Health Service in the U.K. Results Overall, fewer patients were hospitalized in the bisoprolol group, there were fewer hospital admissions perpatient hospitalized, fewer hospital admissions overall, fewer days spent in hospital and fewer days spent in the most expensive type of ward. As a consequence the cost of care in the bisoprolol group was 5-10% less in all three countries, in the per them analysis, even taking into account the cost of bisoprolol and the extra initiation/up-titration visits. The cost per patient treated in the placebo and bisoprolol groups was FF35 009 vs FF31 762 in France, DM11 563 vs DM10 784 in Germany and pound 4987 vs pound 4722 in the U.K. The diagnosis related group analysis gave similar results. Interpretation Not only did bisoprolol increase survival and reduce hospital admissions in CIBIS II, it also cut the cost of care in so doing. This `win-win' situation of positive health benefits associated with cost savings is Favourable from the point of view of both the patient and health care systems. These findings add further support for the use of beta-blockers in chronic heart failure

GROWTH AND MORPHOGENESIS OF SOME MARINE HYDROZOA ACCORDING TO HISTOLOGICAL DATA AND TIME-LAPSE STUDIES

Factors of embryonic polarization in Clava multicornis and Obelia loveni and cellular mechanisms of growth and morphogenesis of vegetal generation mainly in Obelia loveni and Dynamena pumila were studied. Morphological axis of embryo was found to be not determined irreversibly up to morula stage. Unequal distribution of mitotic divisions was demonstrated to be a main cause of embryo elongation. No definite relations were registered between shape and/or growth rate of vegetal rudiments and the characteristics of proliferative processes. Using time-lapse methods, a pulsatory character of growth and shapening was revealed. Growth pulsations are underlined by periodical contractions-extensions of densely packed cells of ecto- and entoderm. Some modes of behaviour of a system, composed by contractile, densely packed cells, are formulated. A number of normal and experimentally modified morphogenetic processes in Hydrozoa may be regarded as direct consequences of the properties of such systems

Morphogenesis can be driven by properly parametrised mechanical feedback

A fundamental problem of morphogenesis is whether it presents itself as a succession of links that are each driven by its own specific cause-effect relationship, or whether all of the links can be embraced by a common law that is possible to formulate in physical terms. We suggest that a common biophysical background for most, if not all, morphogenetic processes is based upon feedback between mechanical stresses (MS) that are imposed to a given part of a developing embryo by its other parts and MS that are actively generated within that part. The latter are directed toward hyper-restoration (restoration with an overshoot) of the initial MS values. We show that under mechanical constraints imposed by other parts, these tendencies drive forth development. To provide specificity for morphogenetic reactions, this feedback should be modulated by long-term parameters and/or initial conditions that are set up by genetic factors. The experimental and model data related to this concept are reviewed