SOLUTION OF THE COUPLED THERMOMECHANICAL PROBLEM OF HYDRODYNAMICS FOR DESIGNING THE PROPULSION SYSTEM OF MICROSATELLITES

This paper considers the problem of predicting the technical and operating characteristics of the propulsion system of a microsatellite created by microelectronic technology. The coupled thermomechanical problem of hydrodynamics has been solved by the ANSYS CFX package. The microengine design has been optimized, the heating of its case in the operating time of the fuel chamber has been analyzed, and the velocity field distribution in the microengine nozzle has been determined. The values of the mechanical and temperature deformation fields for pure silicon and a silicon–SiO2 composite have been found, and the possibility in principle of operation of the considered device has been shown. The calculation was made on a triangular net

Detection of Noble Gas Scintillation Light with Large Area Avalanche Photodiodes (LAAPDs)

Large Area Avalanche Photodiodes (LAAPDs) were used for a series of systematic measurements of the scintillation light in Ar, Kr, and Xe gas. Absolute quantum efficiencies are derived. Values for Xe and Kr are consistent with those given by the manufacturer. For the first time we show that argon scintillation (128 nm) can be detected at a quantum efficiency above 40%. Low-pressure argon gas is shown to emit significant amounts of non-UV radiation. The average energy expenditure for the creation of non-UV photons in argon gas at this pressure is measured to be below 378 eV.Comment: 16 pages, 7 figure

The Pied Piper of Hamelin and Other Melodramas

Research in and through artistic practic

On the Underground Production of High Purity Germanium Detectors

Detectors based on high purity germanium (HPGe) are used in numerous deep underground experiments world-wide aiming at detecting rare events like double beta decay and interactions of dark matter. These detectors require the lowest possible background. A significant part of the background is due to radionuclides produced by cosmic-ray interactions with the germanium crystal. This report gives quantitative data on this activation and discusses the possible solutions. The first solution is to optimise the logistics during the crystal and detector fabrication so that the germanium spends a minimum time above ground. The second solution is to implement one or several (up to 12) production steps underground. The report also makes estimates on the future needs for germanium produced underground and the costs involved.JRC.D.4-Isotope measurement

Peptides against autoimmune neurodegeneration

© 2017 Bentham Science Publishers. The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have created a virtually impenetrable barrier to numerous exogenous pathogens that are assaulting us every moment. Unfortunately, triggers that remain mostly enigmatic will sometimes persuade the immune system to retarget against self-antigens. This civil war remains underway, showing no mercy and taking no captives, eventually leading to irreversible pathological changes in the human body. Research that has emerged during the last two decades has given us hope that we may have a chance to overcome autoimmune diseases using a variety of techniques to "reset" the immune system. In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration

NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble

Universally conserved factors from NusG family bind at the upstream fork junction of transcription elongation complexes and modulate RNA synthesis in response to translation, processing, and folding of the nascent RNA. Escherichia coli NusG enhances transcription elongation in vitro by a poorly understood mechanism. Here we report that E. coli NusG slows Gre factor-stimulated cleavage of the nascent RNA, but does not measurably change the rates of single nucleotide addition and translocation by a non-paused RNA polymerase. We demonstrate that NusG slows RNA cleavage by inhibiting backtracking. This activity is abolished by mismatches in the upstream DNA and is independent of the gate and rudder loops, but is partially dependent on the lid loop. Our comprehensive mapping of the upstream fork junction by base analogue fluorescence and nucleic acids crosslinking suggests that NusG inhibits backtracking by stabilizing the minimal transcription bubble.</p

At the cutting edge against cancer: A perspective on immunoproteasome and immune checkpoints modulation as a potential therapeutic intervention

Simple Summary:&amp; nbsp;Immunoproteasome plays a key role in the generation of antigenic peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic tumors, and to improve its efficacy, a broader knowledge of the dynamics of antigen repertoire processing by cancer cells is mandatory. The scope of this review is to offer a picture of the role of immunoproteasome in antigen presentation to fuel the hypothesis of novel therapeutic interventions based on the modulation of this proteolytic complex and immune checkpoints.Immunoproteasome is a noncanonical form of proteasome with enzymological properties optimized for the generation of antigenic peptides presented in complex with class I MHC molecules. This enzymatic property makes the modulation of its activity a promising area of research. Nevertheless, immunotherapy has emerged as a front-line treatment of advanced/metastatic tumors providing outstanding improvement of life expectancy, even though not all patients achieve a long-lasting clinical benefit. To enhance the efficacy of the currently available immunotherapies and enable the development of new strategies, a broader knowledge of the dynamics of antigen repertoire processing by cancer cells is needed. Therefore, a better understanding of the role of immunoproteasome in antigen processing and of the therapeutic implication of its modulation is mandatory. Studies on the potential crosstalk between proteasome modulators and immune checkpoint inhibitors could provide novel perspectives and an unexplored treatment option for a variety of cancers