Study of Xenopus orthologs of novel genes expressed in the mouse AVE

info:eu-repo/semantics/publishedVersio

Government Spending, Political Cycles, and the Cross Section of Stock Returns

Using a novel measure of industry exposure to government spending, we show predictable variation in cash flows and stock returns over political cycles. During Democratic presidencies, firms with high government exposure experience higher cash flows and stock returns, while the opposite pattern holds true during Republican presidencies. Business cycles, firm characteristics, and standard risk factors do not account for the pattern in returns across presidencies. An investment strategy that exploits the presidential cycle predictability generates abnormal returns as large as 6.9% per annum. Our results suggest market underreaction to predictable variation in the effect of government spending policies

Conducting films based on single-component molecular metals

This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via the DOI in this record.We demonstrate that single component molecular metals can be used as conductive inks for printed electronics. The resistance is 0.3 kΩ sq−1, in a Ni complex, which is one order of magnitude better than that of commercial carbon based conductive inks.The authors would like to acknowledge Fundação para a Ciência e Tecnologia (FCT) for the funding under project PTDC/QEQ-SUP/1413/2012, and project Mais Centro-PORC under contract CENTRO-07-ST24-FEDER-002032. C2TN/IST authors gratefully acknowledge the FCT support through the UID/Multi/04349/2013 project. A. I. S. Neves is thankful to FCT for the PhD grant SFRH/BD/46613/2008. R. A. L. Silva is thankful for the PhD grant SFRH/BD/86131/2012. The authors also acknowledge the contribution of the researchers at C2TN/IST M.M. Andrade and S. Rabaça for the manuscript

Gas-liquid interfacial area in oxygen absorption into oil-in-water emulsions

Present work includes an exhaustive study about gas-liquid interfacial area between gas phase and liquid heterogeneous medium generated in an airlift bioreactor. The model system studied is composed by water, methyl ricinoleate and Tween 80, since it is the base of the medium used for the production of γ-decalactone through the biotransformation of ricinoleic acid, by the yeast Yarrowia lipolytica. Experimental results allow describing the hydrodynamic behavior of the gas phase into the biphasic medium. In the oil-in-water system used, a decrease of the gas-liquid interfacial area with the oil concentration increase was found, due to the redistribution of surfactant between interface and bulk phases

Prolactin-producing pituitary carcinoma, hypopituitarism, and graves' disease-Report of a challenging case and literature review

Introduction: The diagnosis of pituitary carcinoma is very rare, requires the evidence of metastatic disease, and has a poor overall survival. Malignant prolactinoma frequently requires dopamine agonist therapy, pituitary surgery, radiotherapy, and even chemotherapy. Case description: A 19-year-old female presented with galactorrhea, primary amenorrhea, and left hemianopsia. Complementary study detected hyperprolactinemia and a pituitary macroadenoma with cavernous sinus invasion and suprasellar growth. She was treated with cabergoline and bromocriptine without clinical or analytical improvement. Resection of the pituitary lesion was programmed and a non-contiguous lesion of the nasal mucosa was detected during the approach. This metastasis led to the diagnosis of prolactin-producing pituitary carcinoma. After partial resection, the patient was submitted to radiotherapy for residual disease with persistent symptoms. She developed growth hormone deficiency, central hypothyroidism, hypogonadism, and permanent diabetes insipidus. Six years later she was admitted for the suspicion of secondary adrenal insufficiency and thyrotoxicosis. Physical findings, laboratory data, thyroid ultrasound, and scintigraphy achieved the diagnosis of Graves' disease and hypocortisolism. She was treated with hydrocortisone and methimazole, but central hypothyroidism recurred after antithyroid drug withdrawal. Nine years after the diagnosis of a pituitary carcinoma, she maintains treatment with bromocriptine, has a locally stable disease, with no metastases. Conclusion: This report highlights an unusual presentation of a prolactin-producing pituitary carcinoma in a young female. The patient had multiple hormone deficiencies due to a pituitary lesion and treatments. The posterior development of hyperthyroidism and adrenal insufficiency brought an additional difficulty to the approach

Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer

The pivotal mechanisms that govern the correct patterning and regionalization of the distinct areas of the mammalian CNS are driven by key molecules that emanate from the so-called secondary organizers at neural plate and tube stages. FGF8 is the candidate morphogenetic molecule to pattern the mesencephalon and rhombencephalon in the isthmic organizer (IsO). Recognizable relevance has been given to the intracellular pathways by which Fgf8 is regulated and modulated. In chick limb bud development, a dual mitogen-activated protein kinase phosphatase-3 (Mkp3) plays a role as a negative feedback modulator of Fgf8 signaling. We have investigated the role of Mkp3 and its functional relationship with the Fgf8 signaling pathway in the mouse IsO using gene transfer microelectroporation assays and protein-soaked bead experiments. Here, we demonstrate that MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium. (C) 2004 Elsevier Inc. All rights reserved.info:eu-repo/semantics/publishedVersio

Identification of differentially expressed genes in the heart precursor cells of the chick embryo

Genetic evidence has implicated several genes as being critical for heart development. However, the inducers of these genes as well as their targets and pathways they are involved with, remain largely unknown. Previous studies in the avian embryo showed that at HH4 Cerberus (cCer) transcripts are detected in the anterior endomesoderm including the heart precursor cells and later in the left lateral plate mesoderm. We have identified a promoter element of chick cCer able to drive EGFP expression in a population of cells that consistently exit from the anterior primitive streak region, from as early as stage HH3+, and that later will populate the heart. Using this promoter element as a tool allowed us to identify novel genes previously not known to potentially play a role in heart development. In order to identify and study genes expressed and involved in the correct development and differentiation of the vertebrate heart precursor cell (HPC) lineages, a differential screening using Affymetrix GeneChip system technologies was performed. Remarkably, this screening led to the identification of more than 700 transcripts differentially expressed in the heart forming regions (HFR). Bioinformatic tools allowed us to filter the large amount of data generated from this approach and to select a few transcripts for in vivo validation. Whole-mount in situ hybridization and sectioning of selected genes showed heart and vascular expression patterns for these transcripts during early chick development. We have developed an effective strategy to specifically identify genes that are differentially expressed in the HPC lineages. Within this set we have identified several genes that are expressed in the heart, blood and vascular lineages, which are likely to play a role in their development. These genes are potential candidates for future functional studies on early embryonic patterning.Fundação para a Ciência e a Tecnologia Ph.D., PD and BI fellowships; FCT research grants; IGC/FCG; IBB/CBME