277 research outputs found
The Structure of Party-Organization Linkages and the Electoral Strength of Cleavages in Italy, 1963–2008
No consensus exists on the causal mechanisms underpinning declining voting based on social
cleavages – religion and class – in Europe. Previous research has emphasized two main factors: social
change within the electorate (bottom-up) and parties’ policy polarization (top-down). This article
presents a third level of analysis that links parties and cleavage-related social organizations, producing
a factor capable of reinforcing group identity and interest representation. This hypothesis was tested
for Italy in 1968–2008, where changes in the party system provided a natural experiment to assess the
impact of changing structural alternatives at the party–organizational level. The level of cleavage
voting in Italy then responded primarily to changes in the structure of party–organization linkages,
while the impact of policy mobilization and social change was negligible
Macaca sylvanus Linnaeus 1758 from the Middle Pleistocene of Quecchia Quarry (Brescia, Northern Italy)
During the Plio-Pleistocene the Barbary macaque, Macaca sylvanus Linnaeus, 1758 was widely distributed throughout Europe and North Africa (Szalay and Delson, 1979; Delson, 1980; Rook et al., 2001), and it became extinct in Europe during the Late Pleistocene (Elton and O’Regan, 2014). Nowadays this primate is still present in North Africa and a small population has been reintroduced at Gibraltar (Modolo et al., 2005). The taxonomy of the Plio-Pleistocene European macaques is still debated but many authors agree in considering all the fossils as belonging to the M. sylvanus lineage, while the Pleistocene endemic M. majori Azzaroli, 1946 from Sardinia (Italy) has been considered a distinct valid species (Rook and O’Higgins, 2005). The occurrence of this species is documented from Late Pliocene to Late Pleistocene sites located in Northern and Central Italy. Here we describe unpublished dentognathic remains of Macaca sylvanus from the Middle Pleistocene site of Quecchia Quarry (Botticino, Brescia, North Italy)
Present  and  future  climate  simulation  of  Mediterranean  cyclones  with  a  high  resolution  AOGCMs
Preliminary results are presented of a study aiming at producing a climatology of Mediterranean cyclones making use of a global AOGCM coupled with an interactive high-resolution model of the Mediterranean Sea. Cyclones are analyzed with both the lagrangian and the eulerian approaches, applied to three different simulations: a control one (present climate conditions) and two IPCC scenarios (A1B and A2). Both the North Atlantic stormtrack and cyclone track and genesis density statistics from the control dataset are analyzed compared to ERA40 reanalysis. Cyclones are grouped according to their genesis location and the corresponding lysis regions are identified. Partic- ular attention is devoted to the effects of sea-surface fields (temperature gradients and heat fluxes). The wet season (October–March) is examined in relation to the decrease in the intensity of cyclogenesis events in the region and trends are investigated
North Atlantic circulation regimes and heat transport by synoptic eddies
Meridional transport of heat by transient atmospheric eddies is a key component of the energy budget of the middle and high latitude regions. The heat flux at relevant frequencies is also part of a dynamical interaction between eddies and mean flow. In this study we investigate how the poleward heat flux by high frequency atmospheric transient eddies is modulated by North Atlantic weather regimes in reanalysis data. Circulation regimes are estimated via a clustering method, a jet latitude index and a blocking index. Heat transport is defined as advection of moist static energy. The focus of the analysis is on synoptic frequencies but results for slightly longer time scales are reported. Results show that the synoptic eddy heat flux is substantially modulated by mid-latitude weather regimes on a regional scale in midlatitude and polar regions. On a zonal mean sense, the phases of the North Atlantic Oscillation do not change significantly the high latitude synoptic heat flux, whereas Scandinavian blocking and Atlantic Ridge are associated with an intensification. A close relationship between high (mid) latitude heat flux and Atlantic jet speed (latitude) is found. The relationship between extreme events of synoptic heat flux and circulation regimes is also assessed and reveals contrasting behaviours in polar regions. The perspective that emerges complements the traditional view of the interaction between synoptic eddies and the extra-tropical flow and reveals relationships with the high latitude climate
Atypical presentation of juvenile multiple sclerosis in a patient with COVID-19
Purpose: To report our experience with a case of a very atypical clinical onset of multiple sclerosis in a young boy during
a COVID-19 infection.
Case report: A 16-year-old boy was referred to our ophthalmology clinic with a complete isolated bilateral horizontal
gaze palsy. The condition had onset suddenly 2 weeks prior and he had no associated symptoms, as well as no significant
medical history. His corrected visual acuity was 0.0 logMAR in both eyes. While hospitalized, he was found infected with
COVID-19. Subsequent brain MRI showed multiple lesions typical of a yet undiagnosed MS, as well as an active pontine
plaque which was highly probable the cause of the horizontal gaze palsy. High-dose steroid treatment was initiated 1 week
later, after the patient exhibited negative COVID-19 test results.
Conclusion: Clinical manifestations of MS are rarely seen in male teenagers and only a few cases of isolated bilateral
horizontal gaze palsy have been reported as the initial manifestation, but never during concomitant COVID-19 infection.
We presume that the presence of COVID-19 may have been a neuroinflammatory trigger of underlying MS
Atlantic Ocean influence on Middle East summer surface air temperature
Middle East surface air temperature (ME-SAT), during boreal summer (June to August: JJA), shows robust multidecadal variations for the period 1948−2016. Here, using observational and reanalysis datasets, as well as coupled atmosphere–ocean model simulations, we linked the observed summer ME-SAT variability to the multidecadal variability of sea surface temperature (SST) in the North Atlantic Ocean (AMV). This Atlantic−ME connection during summer involves ocean–atmosphere interactions through multiple ocean basins, with an influence from the Indian Ocean and the Arabian Sea. The downstream response to Atlantic SST is a weakening of the subtropical westerly jet stream that impacts summer ME-SAT variability through a wave-like pattern in the upper tropospheric levels. The Atlantic SST response is further characterized by positive geopotential height anomalies in the upper levels over the Eurasian region and a dipole-like pressure distribution over the ME in lower levels. For positive Atlantic SST anomalies this pressure gradient initiates anomalous low-level southerly flow, which transports moisture from the neighboring water bodies toward the extremely hot and dry ME landmass. The increase in atmospheric moisture reduces the longwave radiation damping of the SAT anomaly, increasing further ME-SAT. A suite of Atlantic Pacemaker experiments skillfully reproduces the North Atlantic–ME teleconnection. Our findings reveal that in observations and models the Atlantic Ocean acts as a critical pacemaker for summer ME-SAT multidecadal variability and that a positive AMV can lead to enhanced summer warming over the Middle East
Climate variability and change in the Euro-Mediterranean Region: results from a global AOGCM coupled with an interactive high-resolution model of the Mediterranean Sea
In this work we present and discuss the results obtained from a set of present and future climate simulations performed with a high-resolution model able to represent the dynamics of the Mediterranean Sea. The ability of the model to reproduce the basic features of the observed climate in the Mediterranean region and the beneficial effects of both atmospheric improved resolution and interactive Mediterranean Sea are assessed. In particular, the major characteristics of the variability in the Mediterranean basin and its connection with the large-scale circulation are investigated. Furthermore, the mechanisms through which global warming might affect the regional features of the climate are explored, focusing especially on the characteristics of the hydrological cycle
The Euro-Mediterranean Center on Climate Change (CMCC) decadal prediction system
Decadal climate predictions, obtained by constraining the initial condition of a dynamical model through a truthful estimate of the observed climate state, provide an accurate assessment of near-term climate change and are a useful tool to inform decision-makers on future climate-related risks. Here we present results from the CMIP6 (Coupled Model Intercomparison Project Phase 6) Decadal Climate Prediction Project (DCPP) decadal hindcasts produced with the operational CMCC (Euro-Mediterranean Center on Climate Change) decadal prediction system (DPS), based on the fully coupled CMCC-CM2-SR5 dynamical model. A 20-member suite of 10-year retrospective forecasts, initialized every year from 1960 to 2020, is performed using a full-field initialization strategy. The predictive skill for key variables is assessed and compared with theskill of an ensemble of non-initialized historical simulations so as toquantify the added value of the initialization. In particular, the CMCC DPS is able to skillfully reproduce past climate surface and subsurface temperature fluctuations over large parts of the globe. The North Atlantic Ocean is the region that benefits the most from initialization, with the largest skill enhancement occurring over the subpolar region compared to historical simulations. On the other hand, the predictive skill over the Pacific Ocean rapidly decays with forecast time, especially over the North Pacific. In terms of precipitation, the skill of the CMCC DPS is significantly higher than that of the historical simulations over a few specific regions, including the Sahel, northern Eurasia, and over western and central Europe. The Atlantic multidecadal variability is also skillfully predicted, and this likely contributes to the skill found over remote areas through downstream influence, circulation changes, and teleconnections. Considering the relatively small ensemble size, a remarkable prediction skill is also found for the North Atlantic Oscillation, with maximum correlations obtained in the 1-9 lead year range. Systematic errors also affect the forecast quality of the CMCC DPS,featuring a prominent cold bias over the Northern Hemisphere, which is notfound in the historical runs, suggesting that, in some areas, the adoptedfull-field initialization strategy likely perturbs the equilibrium state ofthe model climate quite significantly. The encouraging results obtained in this study indicate that climatevariability over land can be predictable over a multiyear range, andthey demonstrate that the CMCC DPS is a valuable addition to the currentgeneration of DPSs. This stresses the need to further explore the potentialof the near-term predictions, further improving future decadal systems andinitialization methods, with the aim to provide a reliable tool to inform decision-makers on how regional climate will evolve in the next decade
EFFECTS OF TROPICAL CYCLONES ON OCEAN HEAT TRANSPORT AS SIMULATED BY A HIGH RESOLUTION COUPLED GENERAL CIRCULATION MODEL
In this study the interplay between Tropical Cyclones (TCs) and the Northern hemispheric Ocean Heat Transport (OHT) is investigated. In particular, results from a numerical simulation of the 20th and 21st Century climate, following the Intergovernmental Panel for Climate Change (IPCC) 20C3M and A1B scenario protocols respectively have been analyzed. The numerical simulations have been performed using a state-of-the-art global atmosphere-ocean-sea-ice coupled general circulation model - CGCM (CMCC-MED, Gualdi et al. 2010, Scoccimarro et al. 2010) with relatively high-resolution (T159) in the atmosphere. The model is an evolution of the INGV-SXG (Gualdi et al. 2008, Bellucci et al. 2008) and the ECHAM-OPA-LIM (Fogli et al. 2009, Vichi et al. 2010) The simulated TCs exhibit realistic structure, geographical distribution (Fig.2) and interannual variability, indicating that the model is able to capture the basic mechanisms linking the TC activity with the large scale circulation. The cooling of the surface ocean observed in correspondence of the TCs is well simulated by the model (Fig.3). TC activity is shown to significantly affect the poleward OHT out of the tropics, and the heat transport into the deep tropics (Fig.4). This effect, investigated by looking at the 100 most intense Northern Hemisphere TCs, is strongly correlated with the TC-induced momentum flux at the ocean surface (Fig.7). TCs frequency and
intensity appear to be substantially stationary through the whole 1950-2069 simulated period as well as the effect of the TCs on the meridional OHT
Mild inflammatory profile without gliosis in the c-rel deficient mouse modeling a late-onset parkinsonism
The impact of neuroinflammation and microglial activation to Parkinson’s disease (PD) progression is still debated. Post-mortem analysis of PD brains has shown that neuroinflammation and microgliosis are key features of end-stage disease. However, microglia neuroimaging studies and evaluation of cerebrospinal fluid (CSF) cytokines in PD patients at earlier stages do not support the occurrence of a pronounced neuroinflammatory process. PD animal models recapitulating the motor and non-motor features of the disease, and the slow and progressive neuropathology, can be of great advantage in understanding whether and how neuroinflammation associates with the onset of symptoms and neuronal loss. We recently described that 18-month-old NF-κB/c-Rel deficient mice (c-rel−/−) develop a spontaneous late-onset PD-like phenotype encompassing L-DOPA-responsive motor impairment, nigrostriatal neuron degeneration, α-synuclein and iron accumulation. To assess whether inflammation and microglial activation accompany the onset and the progression of PD-like pathology, we investigated the expression of cytokines (interleukin 1 beta (Il1b), interleukin 6 (Il6)) and microglial/macrophage activation markers (Fc gamma receptor III (Fcgr3), mannose receptor 1 (Mrc1), chitinase-like 3 (Ym1), arginase 1 (Arg 1), triggering receptor expressed on myeloid cells 2 (Trem2)), together with microglial ionized calcium binding adapter molecule 1 (Iba1) and astrocyte glial fibrillary acidic protein (GFAP) immunolabeling, in the substantia nigra (SN) of c-rel−/− mice, at premotor (4- and 13-month-old) and motor phases (18-month-old). By quantitative real-time RT-PCR we found increased M2c microglial/macrophage markers expression (Mrc1 and Arg1) in 4-month-old c-rel−/− mice. M2-type transcription dropped down in 13-month-old c-rel−/− mice. At this age, the pro-inflammatory Il1b, but not Il6 or the microglia-macrophage M1-polarization marker Fcgr3/CD16, increased when compared to wild-type (wt). Furthermore, no significant variation in the transcription of inflammatory and microglial/macrophage activation genes was present in 18-month-old c-rel−/− mice, that display motor dysfunctions and dopaminergic neuronal loss. Immunofluorescence analysis of Iba1-positive cells in the SN revealed no sign of overt microglial activation in c-rel−/− mice at all the time-points. MRC1-Iba1-positive cells were identified as non-parenchymal macrophages in 4-month-old c-rel−/− mice. Finally, no sign of astrogliosis was detected in the SN of the diverse animal groups. In conclusion, this study supports the presence of a mild inflammatory profile without evident signs of gliosis in c-rel−/− mice up to 18 months of age. It suggests that symptomatic PD-like phenotype can develop in the absence of concomitant severe inflammatory process
- …