Preface

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Preface

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On the foundations of cancer modelling: selected topics, speculations, & perspectives

This paper presents a critical review of selected topics related to the modelling of cancer onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical readership, some of the novel mathematical problems in the field. This review attempts to capture, from the appropriate literature, the main issues involved in the modelling of phenomena related to cancer dynamics at all scales which characterise this highly complex system: from the molecular scale up to that of tissue. The last part of the paper discusses the challenge of developing a mathematical biological theory of tumour onset and evolution

Derivation of new chemotaxis models by asymptotic analysis of kinetic models for large binary cell mixtures

This paper deals with the derivation of macroscopic tissue models from the underlying description delivered by a class of equations modeling, by methods of the kinetic theory, binary mixtures of multi-cellular systems. The analysis refers to a suitable parabolic approximation to show how the macroscopic tissue behavior can be described from the underlying cellular description. The approach is specifically focused on the modeling of classical chemotaxis phenomena, and the chemotaxis–flui

Developments of the Hilbert Methods in the Kinetic Theory for Active Particles: Derivation of Cross Diffusion Models

probèlme de copier coller machine windows

Derivation of the particle dynamics from kinetic equations

We consider the microscopic solutions of the Boltzmann-Enskog equation discovered by Bogolyubov. The fact that the time-irreversible kinetic equation has time-reversible microscopic solutions is rather surprising. We analyze this paradox and show that the reversibility or irreversibility property of the Boltzmann-Enskog equation depends on the considered class of solutions. If the considered solutions have the form of sums of delta-functions, then the equation is reversible. If the considered solutions belong to the class of continuously differentiable functions, then the equation is irreversible. Also, we construct the so called approximate microscopic solutions. These solutions are continuously differentiable and they are reversible on bounded time intervals. This analysis suggests a way to reconcile the time-irreversible kinetic equations with the time-reversible particle dynamics. Usually one tries to derive the kinetic equations from the particle dynamics. On the contrary, we postulate the Boltzmann-Enskog equation or another kinetic equation and treat their microscopic solutions as the particle dynamics. So, instead of the derivation of the kinetic equations from the microdynamics we suggest a kind of derivation of the microdynamics from the kinetic equations.Comment: 18 pages; some misprints have been corrected, some references have been adde

Classical Evolution of Quantum Elliptic States

The hydrogen atom in weak external fields is a very accurate model for the multiphoton excitation of ultrastable high angular momentum Rydberg states, a process which classical mechanics describes with astonishing precision. In this paper we show that the simplest treatment of the intramanifold dynamics of a hydrogenic electron in external fields is based on the elliptic states of the hydrogen atom, i.e., the coherent states of SO(4), which is the dynamical symmetry group of the Kepler problem. Moreover, we also show that classical perturbation theory yields the {\it exact} evolution in time of these quantum states, and so we explain the surprising match between purely classical perturbative calculations and experiments. Finally, as a first application, we propose a fast method for the excitation of circular states; these are ultrastable hydrogenic eigenstates which have maximum total angular momentum and also maximum projection of the angular momentum along a fixed direction. %Comment: 8 Pages, 2 Figures. Accepted for publication in Phys. Rev.

Modeling virus pandemics in a globally connected world a challenge towards a mathematics for living systems

This editorial paper presents the papers published in a special issue devoted to the modeling and simulation of mutating virus pandemics in a globally connected world. The presentation is proposed in three parts. First, motivations and objectives are presented according to the idea that mathematical models should go beyond deterministic population dynamics by considering the multiscale, heterogeneous features of the complex system under consideration. Subsequently, the contents of the papers in this issue are presented referring to the aforementioned complexity features. Finally, a critical analysis of the overall contents of the issue is proposed, with the aim of providing a forward look to research perspectives.PostprintPeer reviewe

From a systems theory of sociology to modeling the onset and evolution of criminality

This paper proposes a systems theory approach to the modeling of onset and evolution of criminality in a territory, which aims at capturing the complexity features of social systems. Complexity is related to the fact that individuals have the ability to develop specific heterogeneously distributed strategies, which depend also on those expressed by the other individuals. The modeling is developed by methods of generalized kinetic theory where interactions and decisional processes are modeled by theoretical tools of stochastic game theory.Comment: 20 page

Existence and approximation of probability measure solutions to models of collective behaviors

In this paper we consider first order differential models of collective behaviors of groups of agents based on the mass conservation equation. Models are formulated taking the spatial distribution of the agents as the main unknown, expressed in terms of a probability measure evolving in time. We develop an existence and approximation theory of the solutions to such models and we show that some recently proposed models of crowd and swarm dynamics fit our theoretic paradigm.Comment: 31 pages, 1 figur