A review of knowledge of the potential impacts of GMOs on organic agriculture

The organic movement believes that organic agriculture, by its nature, cannot involve the use of genetically modified organisms (GMOs). This has been incorporated into EU regulations which state that there is no place in organic agriculture for GMOs. The aim in this review is to consider the ways in which the use of GMOs in agriculture in the UK and internationally might impact on organic farming. It does not address the controversy about the rights or wrongs of GMO’s per se. The subjects covered are based on a set of questions raised at the beginning of the study. The review is based primarily on evidence from peer-reviewed literature. The report is based on a number of themes, as follows: • Fate of DNA in soil • Fate of DNA in livestock feed and possible impact of GM feed • Fate of DNA in slurry, manure, compost and mulch • Impact of herbicide tolerant crops • Impact of pest and disease resistant crops • Safety of promoters • DNA transfer in pollen and seeds • Horizontal gene transfer • Impact of scale The report’s Executive Summary includes summaries of the findings on each of these themes

SA-16 Blood Transfusion Importance in the Healing Process of Feline Panleukopenia Leading to DIC (Disseminated Intravascular Coagulation)

INTRODUCTIONFeline panleukopenia caused by feline parvovirus (FPV), which is a highly contagious virus affecting all members of Felidae. Severity of clinical signs depends on age, immune status, and concurrent infections. The severity of the disease varies from the subclinical to sudden death. Typical initial signs include fever, depression, and anorexia.  Cats can initially present vomit with lower frequency, develop watery to hemorrhagic diarrhea. Atypical presentations are common, especially in adult cats. Infected cats die from complications associated with secondary bacterial infection, sepsis, dehydration, and disseminated intravascular coagulopathy (DIC). Mortality rates of 25%-90% in acute panleukopenia and up to 100% in per acute infections have been reported

Idiopathic Brainstem Neuronal Chromatolysis (IBNC): a novel prion protein related disorder of cattle?

<p>Abstract</p> <p>Background</p> <p>The epidemic form of Bovine Spongiform Encephalopathy (BSE) is generally considered to have been caused by a single prion strain but at least two strain variants of cattle prion disorders have recently been recognized. An additional neurodegenerative condition, idiopathic brainstem neuronal chromatolysis and hippocampal sclerosis (IBNC), a rare neurological disease of adult cattle, was also recognised in a sub-set of cattle submitted under the BSE Orders in which lesions of BSE were absent. Between the years of 1988 and 1991 IBNC occurred in Scotland with an incidence of 7 cases per 100,000 beef suckler cows over the age of 6 years.</p> <p>Results</p> <p>When the brains of 15 IBNC cases were each tested by immunohistochemistry, all showed abnormal labelling for prion protein (PrP). Immunohistological labelling for PrP was also present in the retina of a single case available for examination. The pattern of PrP labelling in brain is distinct from that seen in other ruminant prion diseases and is absent from brains with other inflammatory conditions and from normal control brains. Brains of IBNC cattle do not reveal abnormal PrP isoforms when tested by the commercial BioRad or Idexx test kits and do not reveal PrP^reswhen tested by Western blotting using stringent proteinase digestion methods. However, some weakly protease resistant isoforms of PrP may be detected when tissues are examined using mild proteinase digestion techniques.</p> <p>Conclusion</p> <p>The study shows that a distinctive neurological disorder of cattle, which has some clinical similarities to BSE, is associated with abnormal PrP labelling in brain but the pathology and biochemistry of IBNC are distinct from BSE. The study is important either because it raises the possibility of a significant increase in the scope of prion disease or because it demonstrates that widespread and consistent PrP alterations may not be confined to prion diseases. Further studies, including transmission experiments, are needed to establish whether IBNC is a condition in which prion protein is abnormally regulated or it is yet a further example of an infectious cattle prion disease.</p

Global health governance : framework convention on tobacco control (FCTC), the Doha Declaration, and democratisation

Global public health agreements are heralded as a success for the affirmation of the right to health within a complex and contested political landscape. However, the practical implementation of such agreements at the national level is often overlooked. This article outlines two radically different global health agreements: The Doha Declaration on the Trade-Related Aspects of Intellectual Property Rights (TRIPS) agreement and Public Health; and the Framework Convention on Tobacco Control (FCTC). We identify significant challenges in their implementation, particularly for low and middle income countries. Shifts in the policy network constellations around these two agreements have allowed for some positive influence by civil society. Yet industry influence at the national level constrains effective implementation and those affected by these policies have largely been left on the periphery. The broader provisions of these two agreements have been watered down by vested interests and donor conditions. We advocate for both activist and academic actors to play a significant role in highlighting the consequences of these power asymmetries. Deliberative democracy may be the key to addressing these challenges in a way that empowers those presently excluded from effective participation in the policy process.<br /

Discovery of Associated Absorption Lines in an X-Ray Warm Absorber: Hubble Space Telescope Faint Object Spectrograph Observations of MR 2251–178

The presence of a "warm absorber" was first suggested to explain spectral variability in an X-ray spectrum of the radio-quiet quasi-stellar object (QSO) MR 2251-178. A unified picture, in which X-ray warm absorbers and "intrinsic" UV absorbers are the same, offers the opportunity to probe the nuclear environment of active galactic nuclei. To test this scenario and understand the physical properties of the absorber, we obtained a UV spectrum of MR 2251-178 with the Faint Object Spectrograph on board the Hubble Space Telescope (HST). The HST spectrum clearly shows absorption due to Lyα, N V, and C IV, blueshifted by 300 km s^-1 from the emission redshift of the QSO. The rarity of both X-ray and UV absorbers in radio-quiet QSOs suggests these absorbers are physically related, if not identical. Assuming the unified scenario, we place constraints on the physical parameters of the absorber and conclude the mass outflow rate is essentially the same as the accretion rate in MR 2251-178

Applying a midwifery-specific decision-making tool to midwives' clinical reasoning and midwifery practice when managing a woman's perineum in labor: An exploratory study

INTRODUCTION: Many of the risk factors for perineal trauma are modifiable, and midwives are in an ideal position to mitigate such risks. To date, no investigation using a midwifery-specific decision-making tool has sought to determine how midwives make decisions within a midwifery philosophy/context or identify the factors that may contribute to that decision making about perineal management. We sought to apply such a tool to midwives' narratives and explore their clinical reasoning and midwifery practice when managing a woman's perineum in labor. METHODS: A qualitative interview-based study with practicing midwives in one regional Australian maternity unit was conducted. The decision-making matrix specified by a psychometrically robust and validated measure of clinical decision making and midwifery practice-guided analysis. RESULTS: Effective clinical decision making in response to perineal trauma is contingent on a heuristic and individualized "working hypothesis" that combines distinct elements of an optimal clinical decision- making process. Midwives' narratives highlighted their ability to engage in some form of clinical reasoning. Some elements of midwifery practice was lacking within several midwives' narratives, thus resulting in them abdicating their professional role. CONCLUSION: The manner and processes by which midwives engage effectively with perineal management are complex. However, a significant influence on this process appears to be recollections from original training in perineal management, which appears to be largely rote and taught by example. We recommend balance between practical experience and synthesis with current evidence within a midwifery philosophy to optimize perineal care and risk modification