Kant on Perception, Experience and Judgements Thereof

It is commonly thought that the distinction between subjectively valid judgements of perception and objectively valid judgements of experience in the Prolegomena is not consistent with the account of judgement Kant offers in the B Deduction, according to which a judgement is ‘nothing other than the way to bring given cognitions to the objective unity of apperception’. Contrary to this view, I argue that the Prolegomena distinction maps closely onto that drawn between the mathematical and dynamical principles in the System of Principles: Kant’s account of the Prolegomena distinction strongly suggests that it is the Analogies of Experience that make it possible for judgements of perception to give rise to judgements of experience. This means that judgements of perception are objectively valid with regard to the quantity and quality of objects, and subjectively valid with regard to the relation they posit between objects. If that is the case, then the notion of a judgement of perception is consistent with the B Deduction account of judgement

Establishing the Existence of Things in Themselves

In the Critique of Pure Reason, Kant draws a distinction between appearances and things in themselves, characterizing the latter as uncognizable. While arguing that all we can cognize are appearances, Kant nevertheless maintains that there are thing in themselves. This has struck many as questionable: how can we be in a position to affirm, of things stipulated to be uncognizable, that they exist? In this paper, I take up the challenge of establishing the existence of things in themselves. I begin by making the case that, given Kant’s epistemological strictures, the existence of things in themselves must follow analytically from the existence of appearances. After examining the pitfalls of a recent attempt at establishing the existence of things in themselves, I go on to argue that the feature of appearances in virtue of which their existence analytically entails the existence of themselves is the subjectivity of their form. It is implicit in the notion of something with a subjective form that its matter is provided via affection from without. Moreover, the things providing the matter of appearances can’t be located in space and time, because appearances themselves depend on our sensibility for their formal features

Effect of Different Physical Activity Training Methods on Overweight Adolescents

<p class="abstract"><strong>BACKGROUND:</strong> In view of the growing trend of obesity around the world, including in our country, and the effect of reduced physical activity in increasing the incidence of obesity and overweight in children and adolescents and limitations of families in providing transport for their children to attend exercise classes, as well as time limitations of students in taking part in these classes, accessing appropriate methods for presenting physical activity training seems essential.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS:</strong><strong> </strong>This non-pharmacological clinical trial was performed during six months from May to November 2007 on 105 children and adolescents aged 6-18 years with obesity, randomly assigned to 3 groups of thirty-five. Nutrition and treatment behavior were the same in all groups, but physical activity training in the first group was taking part in physical activity training classes twice a week, in the second group by providing a training CD, and in the third group via face-to-face training. Before and after the intervention, anthropometric indicators were measured and recorded.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong> Mean body mass index (BMI) of participants in group attended physical activity training classes, and in the group undergone training with CD, after the interventions was significantly lower than that before the intervention.<strong>&nbsp;</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> Our findings demonstrated that training using CDs can also be effective in reducing BMI in overweight and obese children and adolescents as much as face-to-face education and participation in physical training classes. Extending such interventions can be effective at the community level.</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12"><br /></td></tr> <tr><td><br /></td> <td>&nbsp;</td></tr></tbody></table><p class="abstract">&nbsp;</p> <strong>Keywords:</strong> Children, adolescents, physical activity, education, obesity, treatment

An Approach for Verification of Traffic Speed Deflectometer Measurements

Recent research studies have shown the usefulness and applicability of Traffic Speed Deflectometers (TSD) in support of the network-level pavement management process. There are, however, no accepted procedures for verification and validation of the TSD measurements to be utilized by practitioners. To address this need, TSD measurements may be verified with the data obtained by widely accepted road-testing equipment, Falling Weight Deflectometer (FWD). In this study, TSD and FWD operations on pavement sections were simulated employing the finite layer approach which resulted in the development of a comprehensive database of pavement responses. Using the established numerical simulation database, theoretical relationships between FWD and TSD data were developed by applying machine learning techniques which served as the basis for a robust verification procedure for the TSD measurements. To assure the reliability of the numerical simulations and presented relationships, the results were validated using the data obtained from extensive field testing conducted in various operational and structural conditions

An Approach For Verification Of Traffic Speed Deflectometer Measurements

Recent research studies have shown the usefulness and applicability of Traffic Speed Deflectometers (TSD) in support of the network-level pavement management process. There are, however, no accepted procedures for verification and validation of the TSD measurements to be utilized by practitioners. To address this need, TSD measurements may be verified with the data obtained by widely accepted road-testing equipment, Falling Weight Deflectometer (FWD). In this study, TSD and FWD operations on pavement sections were simulated employing the finite layer approach which resulted in the development of a comprehensive database of pavement responses. Using the established numerical simulation database, theoretical relationships between FWD and TSD data were developed by applying machine learning techniques which served as the basis for a robust verification procedure for the TSD measurements. To assure the reliability of the numerical simulations and presented relationships, the results were validated using the data obtained from extensive field testing conducted in various operational and structural conditions

Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer

Abstract Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One such possible new target is YWHAZ of the 14-3-3 protein family as this gene has prognostic significance for metastatic CRPC patients. However, there are no small molecules targeting YWHAZ commercially available. Hence, we explored whether the small molecule BV02 targeting another 14-3-3 protein family member SFN also binds to YWHAZ. Using advanced docking algorithms we find that BV02 docks many other 14-3-3 family members. In addition, the amphipathic groove where drug binding occurs also has a high binding affinity for other drugs used to treat PCa such as docetaxel. The proteome of metastatic PCa models (LNCaP clone FGC and PC-3) was perturbed as a result of BV02 treatment. Through data integration of three proteomics data sets we found that BV02 modulates numerous protein-protein interactions involving 14-3-3 proteins in our PCa models