The Iowa Homemaker vol.30, no.5

Gift Wrapping Specials, Patricia Keast, page 3 What’s Afoot, Margaret Schaeffer, page 4 Finish That Seam, Barbara Short, page 5 Dance Club in Action, Patricia Binder, page 6 Plastic, Plastic, Everywhere, Marjorie Miller, page 8 Vidhyalaya, Universidad, Universitat, Peg Piaggi, page 9 What’s New, Nancy Voss, page 10 Cooks’ Christmas Favorites, Ruth Behnke, page 12 Alums in the News, Jane Novak, page 14 Here’s An Idea, Carol Dee Legg, page 16 Make It a Record Christmas, Barbara Short, page 2

Virushepatitis C im Jahr 2021

Für das Jahr 2021 wurden insgesamt 4.747 Fälle von Hepatitis C übermittelt, was einer bundesweiten Inzidenz von 5,7 übermittelten Infektionen/100.000 Einwohner entspricht und die Inzidenz des Vorjahres (5,5) nur minimal übersteigt. Der beobachtete Rückgang der Anzahl übermittelter HCV-Infektionen seit 2020 ist möglicherweise bedingt durch Unterdiagnose und -erfassung während der COVID-19-Pandemie. Ein Teil des Rückgangs kann aber auch einem tatsächlichen Rückgang der Inzidenz durch effektive Hepatitis-C-Behandlungen und dadurch seltenerem Auftreten von Transmissionsereignissen entsprechen. Gleichzeitig sinkt jedoch die Zahl der Behandelten kontinuierlich ab, wodurch das Erreichen der Hepatitis-C-Eliminationsziele bis 2030 gefährdet ist. Der Jahresbericht zur Virushepatitis C gibt einen Überblick u. a. über die epidemiologische Situation weltweit, in Europa und in Deutschland sowie den Stand der Hepatitis-C-Eliminierung.Peer Reviewe

The Iowa Homemaker vol.30, no.5

Gift Wrapping Specials, Patricia Keast, page 3 What’s Afoot, Margaret Schaeffer, page 4 Finish That Seam, Barbara Short, page 5 Dance Club in Action, Patricia Binder, page 6 Plastic, Plastic, Everywhere, Marjorie Miller, page 8 Vidhyalaya, Universidad, Universitat, Peg Piaggi, page 9 What’s New, Nancy Voss, page 10 Cooks’ Christmas Favorites, Ruth Behnke, page 12 Alums in the News, Jane Novak, page 14 Here’s An Idea, Carol Dee Legg, page 16 Make It a Record Christmas, Barbara Short, page 20</p

Assessment for learning of paediatric cardiology trainees in 41 centres from 19 European countries

BACKGROUND: Limited data exist on how trainees in paediatric cardiology are assessed among countries affiliated with the Association of European Paediatric and Congenital Cardiology. METHODS: A structured and approved questionnaire was circulated to educationalists/trainers in 95 Association for European Paediatric and Congenital Cardiology training centres. RESULTS: Trainers from 46 centres responded with complete data in 41 centres. Instructional design included bedside teaching (41/41), didactic teaching (38/41), problem-based learning (28/41), cardiac catheterisation calculations (34/41), journal club (31/41), fellows presenting in the multidisciplinary meeting (41/41), fellows reporting on echocardiograms (34/41), clinical simulation (17/41), echocardiography simulation (10/41), and catheterisation simulation (3/41). Assessment included case-based discussion (n = 27), mini-clinical evaluation exercise (mini-CEX) (n = 12), directly observed procedures (n = 12), oral examination (n = 16), long cases (n = 11), written essay questions (n = 6), multiple choice questions (n = 5), and objective structured clinical examination (n = 2). Entrustable professional activities were utilised in 10 (24%) centres. Feedback was summative only in 17/41 (41%) centres, formative only in 12/41 (29%) centres and a combination of formative and summative feedback in 10/41 (24%) centres. Written feedback was provided in 10/41 (24%) centres. Verbal feedback was most common in 37/41 (90 %) centres. CONCLUSION: There is a marked variation in instructional design and assessment across European paediatric cardiac centres. A wide mix of assessment tools are used. Feedback is provided by the majority of centres, mostly verbal summative feedback. Adopting a programmatic assessment focusing on competency/capability using multiple assessment tools with regular formative multisource feedback may promote assessment for learning of paediatric cardiology trainees

Evaluation of Histone Demethylase Inhibitor ML324 and Acyclovir against <i>Cyprinid herpesvirus 3</i> Infection

Cyprinid herpesvirus 3 (CyHV-3) can cause severe disease in koi and common carp (Cyprinus carpio). Currently, no effective treatment is available against CyHV-3 infection in koi. Both LSD1 and JMJD2 are histone demethylases (HD) and are critical for immediate-early (IE) gene activation essential for lytic herpesvirus replication. OG-L002 and ML324 are newly discovered specific inhibitors of LSD1 and JMJD2, respectively. Here, HD inhibitors were compared with acyclovir (ACV) against CyHV-3 infection in vitro and in vivo. ML324, at 20–50 µM, can completely block ~1 × 103 PFU CyHV-3 replication in vitro, while OG-L002 at 20 µM and 50 µM can produce 96% and 98% inhibition, respectively. Only about 94% inhibition of ~1 × 103 PFU CyHV-3 replication was observed in cells treated with ACV at 50 µM. As expected, CyHV-3 IE gene transcription of ORF139 and ORF155 was blocked within 72 h post-infection (hpi) in the presence of 20 µM ML324. No detectable cytotoxicity was observed in KF-1 or CCB cells treated for 24 h with 1 to 50 µM ML324. A significant reduction of CyHV-3 replication was observed in ~6-month-old infected koi treated with 20 µM ML324 in an immersion bath for 3–4 h at 1-, 3-, and 5-days post-infection compared to the control and ACV treatments. Under heat stress, 50–70% of 3–4-month-old koi survived CyHV-3 infection when they were treated daily with 20 µM ML324 in an immersion bath for 3–4 h within the first 5 d post-infection (dpi), compared to 11–19% and 22–27% of koi in the control and ACV treatments, respectively. Our study demonstrates that ML324 has the potential to be used against CyHV-3 infection in koi