27 research outputs found
Environmental enrichment results in both brain connectivity efficiency and selective improvement in different behavioral tasks
Exposure to environmental enrichment (EE) has been a useful model for studying the effects of experience on brain plasticity, but to date, few is known about the impact of this condition on the brain functional networks that probably underlies the multiple behavioral improvements. Hence, we assessed the effect of an EE protocol in adult Wistar rats on the performance in several behavioral tasks testing different domains (Open field (OP): locomotor activity; Elevated-zero maze (EZM): anxiety-related behaviors; 5-choice serial reaction time task (5-CSRTT): attentional processes; 4-arm radial water maze (4-RAWM): spatial memory) in order to check its effectiveness in a wide range of functions. After this, we analyzed the functional brain connectivity underlying each experimental condition through cytochrome C oxidase (COx) histochemistry. Our EE protocol reduced both locomotor activity in the OP and anxiety-related behaviors in the EZM. On the other hand, enriched rats showed more accuracy in the 4-RAWM, whereas 5-CSRTT performance was not significantly ameliorated by EE condition. In relation to COx functional connectivity, we found that EE reduced the number of strong positive correlations both in basal and training conditions, suggesting a modulating effect on specific brain connections. Our results suggest that EE seems to have a selective effect on specific brain regions, such as prefrontal cortex and hippocampus, leading to a more efficient brain connectivity.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
PPIT.UMA.B1.2017/3
Flexible industrial work in the European periphery: factory regimes and changing working class cultures in the Spanish steel industry
This article explores how two steel industry firms operating in northern Spain have adapted to neoliberalism and globalization. Despite their geographical proximity, the comparison between their different trajectories, production, and ownership profiles highlights how their distinct factory regimes, while becoming entangled in global market dynamics, have allowed the emergence of contrasting definitions of workers’ identities, labor politics, and livelihood strategies, raising questions concerning (1) processes of distribution of privileges, skills, and knowledge among the workforce, and (2) the shaping of social relations, values, and meanings that result in the formation of particular factory regimes. The unequal position of steelmaking in regional economies, and the effects of economic policies that framed social relations in each firm, evince important differences between them, including contrasting expressions of resistance, discipline, and sociality on the shop floor. Our comparison considers how particular factory regimes bring forward different prospects as these firms face further industrial transformation, restructuring, and an increasingly uncertain future
Concentration Endurance Test (d2): Normative data for Spanish-speaking pediatric population
Coping with Stress During Aging: The Importance of a Resilient Brain.
Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response. Furthermore, using the EE paradigm, we analyse the resilient potential of this intervention and its neurobiological basis. In this case, we will focus on identifying the characteristics of a resilient brain (modifications in HPA structure and function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others). The evidence suggests that a healthy lifestyle has a crucial role to promote a resilient brain during aging. Along with the behavioral changes described, a better regulation of HPA axis, enhanced levels of postmitotic type-3 cells or changes in GABAergic neurotransmission are some of the brain mechanisms involved in resilience. Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets
c-Fos expression in supramammillary and medial mammillary nuclei following spatial reference and working memory tasks
Abstract To investigate brain substrates of spatial memory, neuronal expression of c-Fos protein was studied. Two groups of rats were trained in two spatial memory tasks in the Morris water maze, where the rats have to apply a reference memory rule or a working memory rule. In addition to the experimental groups, two control groups were used to study c-fos activation not specific to the memory processes studied. After immunohistochemical procedures, the number of c-Fos positive neuronal nuclei was quantified in the mammillary body (MB) region (medial mammillary nucleus [MMn] and supramammillary nucleus [SuM]). The results have shown that some MMn neurons expressed c-Fos nuclear immunoreactivity related to spatial working memory but not to spatial reference memory. The increased number of c-Fos immunoreactive neuronal nuclei in the SuM was related to spatial training but not to either working or reference memory demands of the tasks.
Political exchange, crisis of representation and trade union strategies in a time of austerity
Memoria espacial y cuerpos mamilares
This review critically analyses the implication of the mamillary bodies (MB) in the spatial learning and memory processes. It shows the current controversies in this field and its clinical implications. The experimental works about this subject shown that MB is one of the diencephalic structures that form part of the cerebral circuitry or circuitries underlying memory processes. This review is focused on results from clinical and experimental investigations, that shown the involvement of MB on learning and memory tasks. lt is mainly analysed the behavioral tasks that involve spatial information.En esta revisión se analiza críticamente la implicación de los cuerpos mamilares (CCMM) en procesos de aprendizaje y memoria espacial, poniendo de manifiesto las controversias actuales existentes y sus implicaciones clínicas. La literatura existente sobre el tema parece indicar que los CCMM forman parte de las estructuras diencefálicas relacionadas con el circuito o circuitos cerebrales que subyacen a los procesos de memoria. Esta revisión se centra fundamentalmente en los resultados ofrecidos por la investigación clínica y experimental, que revelan las implicaciones que los CCMM tienen en numerosas tareas de memoria y aprendizaje. Se ha prestado especial atención a aquellas pruebas comportarnentales que requieren el empleo de información espacial
Age differences in path learning: The role of interference in updating spatial information
Spatial orientation is an essential ability, which has shown to decline with aging. Although several researches have focused on the different orientation behaviors and perspectives, fewof them have examined the acquisition
of multiple paths at the same time. The current study was designed with the intention of investigating age differences in multiple view learning, as well as understanding the difficulty in updating spatial information.
Twenty young people, 20 adults and 20 older adults learnt three paths which started and ended from different points of view in the same virtual environment. Results had shown worse performance of the older adults,
although all age groups worsened in the last path. These results showed a severe impact on navigation in aging, and were discussed within aging and spatial cognition domain
Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats
Currently, little is known about the effect of environmental enrichment (EE) on astrocytic plasticity, especially during aging. Given the newly discovered role of the astrocytes in regulating the synaptic transmission and thereby, the cognitive functions, we aimed to study the impact of EE on the performance in a spatial memory task and on the number and morphology of GFAP immunopositive cells in the dorsal hippocampus. After two months of EE (3. h/per day), the animals were tested in the Radial-Arm Water Maze (RAWM) for four days, with six daily trials. Next, we analyzed the changes in the GFAP immunopositive cells in CA1, CA3 and Dentate Gyrus (DG). Behavioral results showed that, even in advanced ages, EE improved the performance in a spatial memory task. Also, we found that aged rats submitted to EE had more GFAP immunopositive cells in the DG and more complex astrocytes, revealed by Sholl analysis, in all hippocampal subfields with respect to the other experimental conditions. Interestingly, the learning of a spatial memory task produced more morphological complexity and higher levels of GFAP immunopositive cells with regard to a standard control group, but not at the same level of the enriched groups. Thus, it is possible that the plastic changes found in the hippocampal astrocytes after EE are involved in a brain reserve to cope with age-related cognitive impairments. © 2014 Elsevier Inc