Modeling of Distributed Ledger Deployment View

The Distributed Ledger Technology (DLT) is a peer-to-peer model of sharing data among collaborating parties in a decentralized manner. An example of DLT is a blockchain where data form blocks in an append-only chain. Software architecture description usually comprises multiple views. The paper concentrates on the Deployment view of the DLT solution within the 1+5 architectural views model. The authors have proposed Unified Modeling Language (UML) extensibility mechanisms to describe the needed additional semantic notation to model deployment details. The paper covers both the network and node levels. The proposed stereotypes and tagged values have enriched the UML Deployment diagram. We have gathered those modeling elements in dedicated UML Profile for Distributed Ledger Deployment. We have applied the profile to model the Deployment view of a renewable energy management system that uses the R3Cordaframework. The system records information about inbound and outbound energy to/from a renewable energy grid

Modeling of Distributed Ledger Deployment View

The Distributed Ledger Technology (DLT) is a peer-to-peer model of sharing data among collaborating parties in a decentralized manner. An example of DLT is a blockchain where data form blocks in an append-only chain. Software architecture description usually comprises multiple views. The paper concentrates on the Deployment view of the DLT solution within the 1+5 architectural views model. The authors have proposed Unified Modeling Language (UML) extensibility mechanisms to describe the needed additional semantic notation to model deployment details. The paper covers both the network and node levels. The proposed stereotypes and tagged values have enriched the UML Deployment diagram. We have gathered those modeling elements in dedicated UML Profile for Distributed Ledger Deployment. We have applied the profile to model the Deployment view of a renewable energy management system that uses the R3Cordaframework. The system records information about inbound and outbound energy to/from a renewable energy grid

učinak propilen-glikola i glicerola na metabolizam ugljikohidrata i masti u kunića - kratko priopćenje

This study examined the effects of glycogenic precursors (propylene glycol and glycerol) on lipid and carbohydrate metabolism of rabbit does fed a restricted diet. The study included 48 females of the Hyplus genetic line, divided into primiparous and multiparous groups. On the 4th day of the restricted diet, the rabbits were orally administered propylene glycol (PG) or glycerol (G), 2 mL/kg body weight0.75. Blood samples were collected immediately prior to administration of the glycogenic precursors and 30, 60, 90, 180, and 360 minutes thereafter. Serum concentrations of glucose, non-esterified fatty acids (NEFA), and β-hydroxybutyric acid were determined. Following the use of both glycogenic precursors, glucose concentration increased after 30 min., which was maintained until the end of the experiment. A significant (P<0.01) decrease in NEFA occurred 120 min after PG was given to primiparous and multiparous does, and remained low up to 360 min after administration. For glycerol, the decrease in NEFA occurred later after 360 min. The mean glucose concentration for the whole period was lower in multiparous females, and higher in primiparous ones. We revealed that both propylene glycol and glycerol showed the evident effect of lipolysis inhibition and gluconeogenesis stimulation, which can be used in practice (e.g. lactation, reproduction).U ovom je radu istraživan učinak glikogenskih pretskazatelja (propilen-glikola i glicerola) na metabolizam masti i ugljikohidrata u kunića hranjenih restriktivnim obrocima. U istraživanje je uključeno 48 ženki genetičke linije Hyplus, podijeljenih u skupine s obzirom na to jesu li primipare ili multipare. Četvrti dan restriktivne hranidbe kunićima je oralno primijenjen propilen-glikol (PG) ili glicerol (G) u dozi od 2 mL/kg tjelesne mase0,75. Uzorci krvi prikupljeni su neposredno prije primjene glikogenskih pretskazatelja te 30, 60, 90, 180 i 360 minuta poslije njihove primjene. Određene su serumske koncentracije glukoze, neesterificiranih masnih kiselina (NEFA) i beta-hidroksimaslačne kiseline. Primjenom obaju glikogenskih pretskazatelja, koncentracija glukoze porasla je nakon 30 minuta i ta se vrijednost zadržala do kraja istraživanja. znakovito smanjenje (P < 0,01) NEFA-e bilo je 120 minuta nakon što je PG primjenjen kod primipara i multipara, te je ostao nizak do 360 minuta nakon primjene. Davanjem glicerola vrijednost NEFA-e smanjila se poslije 360 minuta. Srednja vrijednost glukoze u cijelom tom razdoblju bila je niža u multipara, a viša u primipara. Pokazalo se da i propilen-glikol i glicerol imaju učinak lipolitičke inhibicije i stimulacije glukoneogeneze, što se može primijeniti u praksi, primjerice tijekom laktacije i reprodukcije kunića

Structural studies and selected physical investigations of LiCoO2 obtained by combustion synthesis

Nanocrystalline powders of LiCoO2 were synthesized using a modified solution combustion method, and the effects of the annealing temperature (450-900 degrees C) on structure and composition were investigated using various methods, including XRD, SEM, EPR, and electrical studies. It was found that, as the process temperature increases, the value of the specific surface area decreases, and, hence, the size of the crystallites increases. XRD analysis showed that phase-pure LiCoO2 material was maintained without ad-ditional phases. EPR studies revealed the presence of two Ni3+ complexes resulting from Ni impurities. The electrical properties of the studied LiCoO2 samples were investigated by using impedance spectroscopy. Comparison of the effect of annealing tempera-ture on electrical conductivity shows a very interesting behavior. As the annealing temperature increases, the DC conductivity value increases, reaching a maximum at a temperature of 500 degrees C. However, further increase in the annealing temperature causes a steady decrease in the DC conductivity.Web of Science131482147

Synergistic Enhancement of Diagnostic Imaging: Synthesis and Preliminary Safety Evaluation of Gadolinium-Doped Carbon Quantum Dots as Dual-Contrast Agent

The present study explores the synthesis and bio-safety evaluation of gadolinium-doped carbon quantum dots (GCQDs) as a potential dual-contrast agent for diagnostic imaging. GCQDs exhibit both fluorescent and magnetic properties, making them suitable for UV–Vis and magnetic resonance imaging (MRI). The synthesis of GCQDs was achieved via hydrothermal treatment, incorporating gadolinium into the carbon quantum dot matrix. The magnetic properties of GCQDs were analyzed, showing significantly enhanced values compared to gadobutrol, a common MRI contrast agent. However, synthesis constraints limit the gadolinium content achievable in nanodots. To assess the safety of GCQDs, their effects on the embryonic development of zebrafish (Danio rerio) were examined. Various concentrations of GCQDs were tested, observing mortality rates, hatchability, malformations, heartbeats, spontaneous movement, and GCQDs uptake. Dialysis studies indicated that gadolinium ions are incorporated into the internal structure of the carbon nanodots. Zebrafish toxicity tests revealed that while survival rates were comparable to control groups, hatchability decreased significantly with higher gadolinium concentrations in GCQDs. Fluorescence microscopy showed no statistical differences in the fluorescence intensity between groups. These findings suggest that GCQDs could serve as an effective dual-contrast agent, combining the optical imaging capabilities of CQDs with the enhanced MRI contrast provided by gadolinium. This study underscores the need for further research on the synthesis methods and biological interactions of GCQDs to ensure their safety and efficacy in medical applications

3D PET image reconstruction based on Maximum Likelihood Estimation Method (MLEM) algorithm

Positron emission tomographs (PET) do not measure an image directly. Instead, they measure at the boundary of the field-of-view (FOV) of PET tomograph a sinogram that consists of measurements of the sums of all the counts along the lines connecting two detectors. As there is a multitude of detectors build-in typical PET tomograph structure, there are many possible detector pairs that pertain to the measurement. The problem is how to turn this measurement into an image (this is called imaging). Decisive improvement in PET image quality was reached with the introduction of iterative reconstruction techniques. This stage was reached already twenty years ago (with the advent of new powerful computing processors). However, three dimensional (3D) imaging remains still a challenge. The purpose of the image reconstruction algorithm is to process this imperfect count data for a large number (many millions) of lines-of-responce (LOR) and millions of detected photons to produce an image showing the distribution of the labeled molecules in space.Comment: 10 pages, 7 figure

Pleomorphic adenoma of the nasal cavity in a 21 – year – old patient – case report

Introduction and aim: Adenoma pleomorphum (multiform adenoma) is the most popular bening tumor, that originates from the salivary glands. Neoplasm develops mainly from large salivary glands and its occurrence in the nasal cavity is rare and falls mainly in the 3-6 decade of life. Only 1% of all pleomorphic adenomas develop in the nasal and sinus cavities. Despite being a benign tumor, malignant transformation can occur in 2-10% of cases. Description of the case: We report a case of a 21-year-old female ethnically Polish patient with nasal multiform adenoma with initial diagnosis, which indicated a polyp. The final diagnosis was based on the histopathological examination of the resected lesion. The tumor was removed by an endoscopic method with no tissue margins, which may increase the risk of recurrence. Conclusions: Our case demonstrates that despite pleomorphic adenomas typically occurs in the 3rd to 6th decade of life,  clinical symptoms are nondistinctive with a polyp and nasal cavity is a very rare location there should be always be increased vigilance leading to choosing best diagnostic measures to form right diagnosis

Plastic scintillators for positron emission tomography obtained by the bulk polymerization method

This paper describes three methods regarding the production of plastic scintillators. One method appears to be suitable for the manufacturing of plastic scintillator, revealing properties which fulfill the requirements of novel positron emission tomography scanners based on plastic scintillators. The key parameters of the manufacturing process are determined and discussed.Comment: 7 pages, 4 figure