Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions.

Akin to approaches encouraged by Verano (1997) in the Andes, and Ortner (2011, 2012) for general paleopathological studies, this article focuses on accurate descriptions and definitions of osteoarthritis, entheses, and long bone cross-sectional geometry. By evaluating these conditions as part of biological responses to abnormal skeletal changes and biomechanical stress, this research discusses each condition's pathogenesis. Further, this article emphasizes a "small data" approach to evaluating these conditions in ancient culturally and biologically related human populations, where the study samples must have good skeletal preservation, where estimates of age and sex need to be included as major factors, and where abnormalities need to be described and evaluated. This article also discusses global clinical and osteological research on ways scholars are currently trying to establish industry-wide methods to evaluate osteoarthritis, entheses, and long bone cross-sectional geometry. Recent studies have focused on rigorous evaluation of methodological techniques, recording protocols, and inter- and intra-observer error problems. Additionally, scholars have focused on physical intensity of movement using biomechanics, evaluated burials of known occupation, and used complex statistical methods to help interpret skeletal changes associated with these conditions. This article also narrows to focus on these conditions within thematic "small data" areas throughout the Andes. This research concludes with describing future directions to understand skeletal changes, such as more multidisciplinary studies between osteologists and pathologists, collaborations with living people to collect CT, x-rays, or computer-aided motion capture, and a stronger focus on how these conditions correlate with intense biomechanical changes in younger individuals

Labor and the Rise of the Tiwanaku State (AD 500-1100): A Bioarchaeological Study of Activity Patterns

This dissertation focused on understanding labor during the development of Tiwanaku (AD 500-1100), one of the earliest Andean states. Prior archaeological research (Kolata 1991, 1993a, b; Stanish 1994, 2003) argued that Tiwanaku labor was centralized under a corvée mit'a system. Labor was controlled and distributed by elites living within the city of Tiwanaku under a hierarchical political organization (Kolata 2003a). Other research (e.g. Albarracín-Jordán 2003; Erickson 2006) argued that local and decentralized control of labor, with workforce cooperation and collaboration under a heterarchical political system, was an important factor to the state's emergence, formation, and expansion. The author interpreted bioarchaeological research on Tiwanaku skeletal remains in order to answer questions about the Tiwanaku workforce, possible agriculture or craft-based activities performed, workload levels, gendered division of labor, as well as the political structure of the state. Skeletal sampDoctor of Philosoph

In politics, caricatures can become facts, and that is bad for everyone

The distortion of facts is nothing new to politics and election campaigns. But, with the rise of the internet and 24-hour news cycle, rumors and conspiracy theories can now spread easier than ever through social networks to reach potential voters. Michael Cacciatore and co-authors look at two examples from the 2008 presidential election campaign to better understand how unsubstantiated rumors can become facts in voters’ minds. They find that values, including political ideology and evangelical Christian status, were primarily responsible for propelling misperceptions about President Barack Obama’s faith, while media use played a more important role in driving the misperception that Sarah Palin, and not Saturday Night Live’s Tina Fey, was responsible for the “I can see Russia from my house” quote. The latter finding lends some credibility to the so-called “lamestream media” effect often espoused by prominent Republican figures

Evaluation of single and double-locus real-time PCR assays for methicillin-resistant Staphylococcus aureus (MRSA) surveillance

<p>Abstract</p> <p>Background</p> <p>Methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) is a human pathogen, representing an infection control challenge. Conventional MRSA screening takes up to three days, therefore development of rapid detection is essential. Real time-PCR (rt-PCR) is the fastest method fulfilling this task. All currently published or commercially available rt-PCR MRSA assays relay on single or double-locus detection. Double-locus assays are based on simultaneous detection of <it>mecA </it>gene and a <it>S. aureus</it>-specific gene. Such assays cannot be applied on clinical samples, which often contain both coagulase-negative staphylococci (CoNS) and <it>S. aureus</it>, either of which can carry <it>mecA</it>. Single-locus assays are based on detection of the staphylococcal cassette chromosome <it>mec </it>(SCC<it>mec</it>) element and the <it>S. aureus</it>-specific <it>orfX </it>gene, assuming that it is equivalent to <it>mecA </it>detection.</p> <p>Findings</p> <p>Parallel evaluation of several published single and double-locus rt-PCR MRSA assays of 150 pure culture strains, followed by analysis of 460 swab-derived clinical samples which included standard identification, susceptibility testing, followed by PCR detection of staphylococcal suspected isolates and in-PCR mixed bacterial populations analysis indicated the following findings.</p> <p>Pure cultures analysis indicated that one of the single-locus assay had very high prevalence of false positives (Positive predictive value = 77.8%) and was excluded from further analysis. Analysis of 460 swab-derived samples indicated that the second single-locus assay misidentified 16 out of 219 MRSA's and 13 out of 90 methicillin-sensitive <it>S</it>. <it>aureus</it>'s (MSSA) were misidentified as MRSA's. The double-locus detection assay misidentified 55 out of 90 MSSA's. 46 MSSA containing samples were misidentified as MRSA and 9 as other than <it>S. aureus </it>ending with low positive predicted value (<85%) and very low specificity (<62%).</p> <p>Conclusion</p> <p>The results indicate that high prevalence of false-positive and false-negative reactions occurs in such assays.</p

Britain’s slow movement to a gender egalitarian equilibrium: parents and employment in the UK 2001–13

This article examines the working lives of British couple families across the first decade of the millennium using EU Labour Force Survey data (2001–13) taking a multiple equilibria approach. Some growth in dual full-time earners, increased working hours of mothers in part-time employment and a growing proportion of households with ‘non-standard’ working patterns are all identified, suggesting both a convergence and greater diversity in economic provisioning within parent couple households. Household employment patterns remain strongly associated with maternal education and family size but are becoming less sensitive to the age of the youngest child. The dual full-time earner model is growing in significance for British parents of young children but a new gender egalitarian equilibrium has not yet been reached

The Effects of Earthquake Experience on Intentions to Respond to Earthquake Early Warnings

Warning systems are essential for providing people with information so they can take protective action in response to perils. Systems need to be human-centered, which requires an understanding of the context within which humans operate. Therefore, our research sought to understand the human context for Earthquake Early Warning (EEW) in Aotearoa New Zealand, a location where no comprehensive EEW system existed in 2019 when we did this study. We undertook a survey of people's previous experiences of earthquakes, their perceptions of the usefulness of a hypothetical EEW system, and their intended responses to a potential warning (for example, Drop, Cover, Hold (DCH), staying still, performing safety actions). Results showed little difference in perceived usefulness of an EEW system between those with and without earthquake experience, except for a weak relationship between perceived usefulness and if a respondent's family or friends had previously experienced injury, damage or loss from an earthquake. Previous earthquake experience was, however, associated with various intended responses to a warning. The more direct, or personally relevant a person's experiences were, the more likely they were to intend to take a useful action on receipt of an EEW. Again, the type of experience which showed the largest difference was having had a family member or friend experience injury, damage or loss. Experience of participation in training, exercises or drills did not seem to prompt the correct intended actions for earthquake warnings; however, given the hypothetical nature of the study, it is possible people did not associate their participation in drills, for example, with a potential action that could be taken on receipt of an EEW. Our analysis of regional differences highlighted that intentions to mentally prepare on receipt of a warning were significantly higher for Canterbury region participants, most likely related to strong shaking and subsequent impacts experienced during the 2010–11 Canterbury Earthquake Sequence. Our research reinforces that previous experience can influence earthquake-related perceptions and behaviors, but in different ways depending on the context. Public communication and interventions for EEW could take into consideration different levels and types of experiences of the audience for greater success in response

Stakeholder engagement to ensure the sustainability of biobanks: a survey of potential users of biobank services

Biobanks are important infrastructures facilitating biomedical research. After a decade of rolling out such infrastructures, a shift in attention to the sustainability of biobanks could be observed in recent years. In this regard, an increase in the as yet relatively low utilisation rates of biobanks has been formulated as a goal. Higher utilisation rates can only be achieved if the perspectives of potential users of biobanks-particularly researchers not yet collaborating with biobanks-are adequately considered. To better understand their perspectives, a survey was conducted at ten different research institutions in Germany hosting a centralised biobank. The survey targeted potential users of biobank services, i.e. researchers working with biosamples. It addressed the general demand for biosamples, strategies for biosample acquisition/storage and reasons for/against collaborating with biobanks. In total, 354 researchers filled out the survey. Most interestingly, only a minority of researchers (12%) acquired their biosamples via biobanks. Of the respondents not collaborating with biobanks on sample acquisition, around half were not aware of the (services of the) respective local biobank. Those who actively decided against acquiring biosamples via a biobank provided different reasons. Most commonly, respondents stated that the biosamples required were not available, the costs were too high and information about the available biosamples was not readily accessible. Biobanks can draw many lessons from the results of the survey. Particularly, external communication and outreach should be improved. Additionally, biobanks might have to reassess whether their particular collection strategies are adequately aligned with local researchers' needs

Attracting volunteers in highly multicultural societies: a marketing challenge

Volunteer managers face a typical marketing problem: how to identify the right consumers (in this case, volunteers), attract them, and keep them loyal. In multicultural societies this challenge is amplified because of the different groups originating from countries that can vary significantly in terms of the extent of volunteering and reasons for being involved. The consequence of this heterogeneity is limited success of generic marketing campaigns. Using the theory of planned behavior, we investigate differences between Australian residents from different cultural backgrounds in their volunteering behavior. Groups differed in attitude, social norm, and perceived behavioral control, suggesting the need for customized marketing strategies. Theoretically, results provide evidence that volunteers in multicultural societies cannot be viewed as one homogeneous mass. Practically, results offer insight into the factors influencing the behavior of each cultural group, and can inform customized campaigns to tap into the large base of volunteers from different backgrounds