87 research outputs found
L'enseignant-ressource : "un prof qui parle aux profs"
Disponible en anglais dans EDUQ.info sous le titre "The resource teacher : "a teacher who talks to teachers"Lâarticle prĂ©sente le projet « Un prof qui parle aux profs » menĂ© au CĂ©gep du Vieux MontrĂ©al. Lâobjectif de ce projet est de reconnaitre les besoins des professeurs qui accueillent dans leur classe des Ă©tudiants en situation de handicap. Face aux accommodements requis afin de rĂ©pondre aux besoins de ces Ă©tudiants, les professeurs se voient dans lâobligation de dĂ©lĂ©guer une partie de leurs responsabilitĂ©s pĂ©dagogiques aux services adaptĂ©s. Ce nouveau paradigme suscite de nombreuses questions chez les professeurs. Bien sĂ»r, les conseillers en services adaptĂ©s sont en mesure de discuter des adaptations requises avec les professeurs. Au CĂ©gep du Vieux MontrĂ©al on a toutefois jugĂ© nĂ©cessaire de libĂ©rer un professeur qui agit Ă titre dâenseignant-ressource, capable dâaccueillir les prĂ©occupations des professeurs et proposant une approche centrĂ©e sur les pratiques pĂ©dagogiques de lâenseignant. Lâenseignant-ressource rĂ©alise ainsi un type de traduction entre lâenseignant et le conseiller en services adaptĂ©s, de maniĂšre Ă ce que les professeurs trouvent un Ă©cho aux besoins quâils Ă©prouvent comme pĂ©dagogues. Lâarticle expose le cadre thĂ©orique de cette expĂ©rimentation, les rĂŽles de chacun ainsi que les effets du projet Ă ce jour
âJust want to surf, make boards and partyâ: how do we identify lifestyle entrepreneurs within the lifestyle sports industry?
This paper aims to further our understanding of the identity of the lifestyle entrepreneur operating within the lifestyle sports industry. The lifestyle entrepreneur has to date been
the subject of numerous definitions. However, understanding the context in which entrepreneurs operate has been identified by researchers as impacting upon the actions they take, and so therefore linking context to the entrepreneur is critical to the understanding of these individuals. A mixed methods study comprising of 80 questionnaire responses, and 21 semi-structured interviews focussed on identifying lifestyle
sports entrepreneurs. Two groups of entrepreneurs were targeted; those entrepreneurs operating within a sport (Engagers) and those who run a business to participate
(Enablers). Issues surrounding the identification of lifestyle entrepreneurs are presented. Through the analysis of the data, entrepreneurs identified through their own narratives how their identities are created. The results demonstrate that while the current external interpretation of the lifestyle entrepreneur is of a fixed nature, the entrepreneurs themselves evidence a much more complex approach to their identities
Les barrieÌres autistiques en art-theÌrapie : eÌtude de cas explorant l'expression des meÌcanismes relationnels et deÌfensifs autistiques en art theÌrapie
This research is the observation of autistic barriers presented in art-therapy with two patients who suffer from diverse somatization problems. This is a case study, in which psychoanalytical epistemology is theoretically supported by several modern theories of the primitive development of self and object relations, notably 'autistic barriers' by Frances Tustin (1990) and 'autistic-contiguous position' by Thomas Ogden (1989). In this research, it is proposed that fibromyalgia and self mutilation, in the cases studied, are primitive autistic defense mechanisms, like the ones described by Tustin. Ogden's theory, on the other hand, permits one to theoretically position the persistence of these autistic defense phenomena in people suffering from diverse somatization problems. Ogden introduces, within the post-kleinian theory, a first position, one of object relations, named "the autistic-contiguous" position as well as a conceptual dialectic of the functioning psyche. The autistic-contiguous position is conceived as the primitive and sensory background of the paranoid-schizoid position. This research will also attempt to describe and distinguish autistic-contiguous (Ogden) and paranoid-schizoid (Klein) positions. Two clinical cases will be presented, offering signs of the presence of autistic defensive mechanisms throughout the study. The conclusions of this study will permit art-therapy to be seen as a therapy of choice, capable of transforming asymbolic experiences to symbolic ones
Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos
AbstractWe have previously shown that hepcidin transgenic embryos are severely anemic and die around birth. Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity. On the contrary, iron injections into pregnant mothers result in increased placenta iron and ferritin content, and reduced IRE binding activity of IRP1 leading to decreased TfR1 mRNA level. Taken together, these results suggest that hepcidin action on placenta is mostly through transcriptional downregulation of the iron uptake machinery
Evidence gathering in support of sustainable Scottish inshore fisheries: work package (5) final report: improving market intelligence and fishery production co-ordination in Scottish inshore fisheries â a pilot study
[Extract from Executive Summary] This work package builds on a broad brush scaling of the volume, composition and geographical disposition of inshore sector landings to inform examination of market linkages, identify supply chain weaknesses, and explore opportunities to increase producer prices â focusing on a small number of case study areas. Analysis has sought to identify opportunities and mechanisms by which the inshore sector might counter the disadvantages it routinely suffers due to its small-scale of operation and its geographic peripherality.Publisher PD
Evidence gathering in support of sustainable Scottish inshore fisheries: work package (6) final report: integrating stock management considerations with market opportunities in the Scottish inshore fisheries sector â a pilot study
In June 2014, Hambrey Consulting successfully responded to a call for tenders for research to undertake a pilot assessment of the potential economic and associated benefits of establishing minimum market landing size (MMLS) in excess of minimum legal landing size (MLS) for shellfish; and to evaluate if such an intervention could be undertaken at a regional level.
The project was originally conceived as including 3 case studies, but the scope of the research led us to focus mainly on the trawl and creel fishery for Nephrops prosecuted by the fleet based in Skye and SW Ross. The basic framework for the assessment approach was to: Develop an economic profile of the case study area and its fishing fleet; Review and synthesise existing data on size profile of the catch, the factors that affect size, including costs associated with individual (vessel) actions or strategies to increase the size profile of the catch; Analyse market and market trends, and the prices for different sizes of product; Develop economic models of representative fishing enterprises, taking account of the relationships between costs and returns and the size profile of the catch; Use plausible scenarios to explore likely short term economic consequences of any changes in MMLS; Use yield and utility per recruit analysis to explore possible yield benefits associated with increased MMLS.Publisher PD
Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity.
L'article final de l'éditeur contient 9 pages. Le manuscrit accepté contient 32 pages.International audienceMutations of the TMPRSS6 gene, which encodes Matriptase-2, are responsible for iron-refractory iron-deficiency anemia. Matriptase-2 is a transmembrane protease that downregulates hepcidin expression. We report one frameshift (p.Ala605ProfsX8) and four novel missense mutations (p.Glu114Lys, p.Leu235Pro, p.Tyr418Cys, p.Pro765Ala) found in IRIDA patients. These mutations lead to changes in both the catalytic and noncatalytic domains of Matriptase-2. Analyses of the mutant proteins revealed a reduction of autoactivating cleavage and the loss of N-Boc-Gln-Ala-Arg-p-nitroanilide hydrolysis. This resulted either from a direct modification of the active site or from the lack of the autocatalytic cleavage that transforms the zymogen into an active protease. In a previously described transfection assay measuring the ability of Matriptase-2 to repress the hepcidin gene (HAMP) promoter, all mutants retained some, if not all, of their transcriptional repression activity. This suggests that caution is called for in interpreting the repression assay in assessing the functional relevance of Matriptase-2 substitutions. We propose that Matriptase-2 activity should be measured directly in the cell medium of transfected cells using the chromogenic substrate. This simple test can be used to determine whether a sequence variation leading to an amino acid substitution is functionally relevant or not
Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice
Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy. Mitochondria in the lumbar spinal cord showed significantly decreased Complex I and II activities, and abnormal morphology. Lower motor neurons appeared to be the most adversely affected neurons, and we show that functional iron starvation due to misregulation of iron import and storage proteins, including transferrin receptor 1 and ferritin, may have a causal role in disease. We demonstrated that two therapeutic approaches were beneficial for motor neuron survival. First, we activated a homologous protein, IRP1, by oral Tempol treatment and found that axons were partially spared from degeneration. Secondly, we genetically decreased expression of the iron storage protein, ferritin, to diminish functional iron starvation. These data suggest that functional iron deficiency may constitute a previously unrecognized molecular basis for degeneration of motor neurons in mice
Crystallization and preliminary X-ray diffraction data of mouse L-chain apoferritin crystals
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